Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice

Autores
Martín, Mauricio Gerardo; Dotti, Carlos
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Huntington's Disease (HD) is a devastating neurodegenerative disorder characterized by progressive cognitive and motor impairment. Multiple studies have shown impaired cholesterol biosynthesis in the brains of HD patients and various rodent models and different strategies have explored to which extent modulation of brain cholesterol levels could be beneficial for HD cognitive and motor deficits. The work titled "Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease" by Birolini et al. is the culmination of 25 years of effort by Elena Cattaneo's research group in this area...
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Dotti, Carlos. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España
Materia
CHOLESTEROL
HUNTINGTON
THERAPY
NEURODEGENERATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/251688
Acceder
id CONICETDig_6edc995a9cab6f9cef55afa3524504f2
oai_identifier_str oai:ri.conicet.gov.ar:11336/251688
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in miceMartín, Mauricio GerardoDotti, CarlosCHOLESTEROLHUNTINGTONTHERAPYNEURODEGENERATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Huntington's Disease (HD) is a devastating neurodegenerative disorder characterized by progressive cognitive and motor impairment. Multiple studies have shown impaired cholesterol biosynthesis in the brains of HD patients and various rodent models and different strategies have explored to which extent modulation of brain cholesterol levels could be beneficial for HD cognitive and motor deficits. The work titled "Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease" by Birolini et al. is the culmination of 25 years of effort by Elena Cattaneo's research group in this area...Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Dotti, Carlos. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; EspañaAcademic Press Ltd - Elsevier Science Ltd2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/251688Martín, Mauricio Gerardo; Dotti, Carlos; Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 194; 106879; 8-2023; 1-21043-6618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2023.106879info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043661823002359info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:34Zoai:ri.conicet.gov.ar:11336/251688instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:35.091CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
title Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
spellingShingle Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
Martín, Mauricio Gerardo
CHOLESTEROL
HUNTINGTON
THERAPY
NEURODEGENERATION
title_short Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
title_full Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
title_fullStr Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
title_full_unstemmed Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
title_sort Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice
dc.creator.none.fl_str_mv Martín, Mauricio Gerardo
Dotti, Carlos
author Martín, Mauricio Gerardo
author_facet Martín, Mauricio Gerardo
Dotti, Carlos
author_role author
author2 Dotti, Carlos
author2_role author
dc.subject.none.fl_str_mv CHOLESTEROL
HUNTINGTON
THERAPY
NEURODEGENERATION
topic CHOLESTEROL
HUNTINGTON
THERAPY
NEURODEGENERATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Huntington's Disease (HD) is a devastating neurodegenerative disorder characterized by progressive cognitive and motor impairment. Multiple studies have shown impaired cholesterol biosynthesis in the brains of HD patients and various rodent models and different strategies have explored to which extent modulation of brain cholesterol levels could be beneficial for HD cognitive and motor deficits. The work titled "Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease" by Birolini et al. is the culmination of 25 years of effort by Elena Cattaneo's research group in this area...
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Dotti, Carlos. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España
description Huntington's Disease (HD) is a devastating neurodegenerative disorder characterized by progressive cognitive and motor impairment. Multiple studies have shown impaired cholesterol biosynthesis in the brains of HD patients and various rodent models and different strategies have explored to which extent modulation of brain cholesterol levels could be beneficial for HD cognitive and motor deficits. The work titled "Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease" by Birolini et al. is the culmination of 25 years of effort by Elena Cattaneo's research group in this area...
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/251688
Martín, Mauricio Gerardo; Dotti, Carlos; Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 194; 106879; 8-2023; 1-2
1043-6618
CONICET Digital
CONICET
url http://hdl.handle.net/11336/251688
identifier_str_mv Martín, Mauricio Gerardo; Dotti, Carlos; Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 194; 106879; 8-2023; 1-2
1043-6618
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2023.106879
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043661823002359
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613558128607232
score 13.070432

Publicaciones similares