Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years

Autores
Larghi, Enrique Leandro; Bracca, Andrea Beatriz Juana; Simonetti, Sebastián Osvaldo; Kaufman, Teodoro Saul
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multicomponent reactions (MCRs) are a valuable strategy toward complex polysubstituted compounds because they simplify long sequences, increasing their efficiency. The total synthesis of natural products achieved since 2004 through the use of three-component reactions as a strategic MCR approach is reviewed. Successful sequences are described, along with relevant information on the isolation and bioactivity of the selected targets.
Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Bracca, Andrea Beatriz Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Simonetti, Sebastián Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
THREE-COMPONENTS REACTION
TOTAL SYNTHESIS
NATURAL PRODUCTS
HETEROCYCLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267359
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 YearsLarghi, Enrique LeandroBracca, Andrea Beatriz JuanaSimonetti, Sebastián OsvaldoKaufman, Teodoro SaulTHREE-COMPONENTS REACTIONTOTAL SYNTHESISNATURAL PRODUCTSHETEROCYCLEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Multicomponent reactions (MCRs) are a valuable strategy toward complex polysubstituted compounds because they simplify long sequences, increasing their efficiency. The total synthesis of natural products achieved since 2004 through the use of three-component reactions as a strategic MCR approach is reviewed. Successful sequences are described, along with relevant information on the isolation and bioactivity of the selected targets.Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Bracca, Andrea Beatriz Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Simonetti, Sebastián Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaWiley-VCH2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267359Larghi, Enrique Leandro; Bracca, Andrea Beatriz Juana; Simonetti, Sebastián Osvaldo; Kaufman, Teodoro Saul; Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years; Wiley-VCH; ChemistryOpen; 13; 5; 4-2024; 1-192191-1363CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.202300306info:eu-repo/semantics/altIdentifier/doi/10.1002/open.202300306info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:07:14Zoai:ri.conicet.gov.ar:11336/267359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:07:15.094CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
title Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
spellingShingle Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
Larghi, Enrique Leandro
THREE-COMPONENTS REACTION
TOTAL SYNTHESIS
NATURAL PRODUCTS
HETEROCYCLES
title_short Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
title_full Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
title_fullStr Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
title_full_unstemmed Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
title_sort Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years
dc.creator.none.fl_str_mv Larghi, Enrique Leandro
Bracca, Andrea Beatriz Juana
Simonetti, Sebastián Osvaldo
Kaufman, Teodoro Saul
author Larghi, Enrique Leandro
author_facet Larghi, Enrique Leandro
Bracca, Andrea Beatriz Juana
Simonetti, Sebastián Osvaldo
Kaufman, Teodoro Saul
author_role author
author2 Bracca, Andrea Beatriz Juana
Simonetti, Sebastián Osvaldo
Kaufman, Teodoro Saul
author2_role author
author
author
dc.subject.none.fl_str_mv THREE-COMPONENTS REACTION
TOTAL SYNTHESIS
NATURAL PRODUCTS
HETEROCYCLES
topic THREE-COMPONENTS REACTION
TOTAL SYNTHESIS
NATURAL PRODUCTS
HETEROCYCLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multicomponent reactions (MCRs) are a valuable strategy toward complex polysubstituted compounds because they simplify long sequences, increasing their efficiency. The total synthesis of natural products achieved since 2004 through the use of three-component reactions as a strategic MCR approach is reviewed. Successful sequences are described, along with relevant information on the isolation and bioactivity of the selected targets.
Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Bracca, Andrea Beatriz Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Simonetti, Sebastián Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description Multicomponent reactions (MCRs) are a valuable strategy toward complex polysubstituted compounds because they simplify long sequences, increasing their efficiency. The total synthesis of natural products achieved since 2004 through the use of three-component reactions as a strategic MCR approach is reviewed. Successful sequences are described, along with relevant information on the isolation and bioactivity of the selected targets.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267359
Larghi, Enrique Leandro; Bracca, Andrea Beatriz Juana; Simonetti, Sebastián Osvaldo; Kaufman, Teodoro Saul; Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years; Wiley-VCH; ChemistryOpen; 13; 5; 4-2024; 1-19
2191-1363
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267359
identifier_str_mv Larghi, Enrique Leandro; Bracca, Andrea Beatriz Juana; Simonetti, Sebastián Osvaldo; Kaufman, Teodoro Saul; Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years; Wiley-VCH; ChemistryOpen; 13; 5; 4-2024; 1-19
2191-1363
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.202300306
info:eu-repo/semantics/altIdentifier/doi/10.1002/open.202300306
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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