Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats

Autores
Puia, Sebastian A.; Renou, Sandra Judith; Rey, Eduardo A.; Guglielmotti, Maria Beatriz; Bozzini, Carlos Eduardo Jose
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80 ± 5 g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.
Fil: Puia, Sebastian A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Rey, Eduardo A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Materia
BISMUTH SUBGALLATE
BONE HEALING
HEMOSTATIC AGENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161983
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in ratsPuia, Sebastian A.Renou, Sandra JudithRey, Eduardo A.Guglielmotti, Maria BeatrizBozzini, Carlos Eduardo JoseBISMUTH SUBGALLATEBONE HEALINGHEMOSTATIC AGENThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80 ± 5 g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.Fil: Puia, Sebastian A.. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Rey, Eduardo A.. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaChurchill Livingstone2009-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161983Puia, Sebastian A.; Renou, Sandra Judith; Rey, Eduardo A.; Guglielmotti, Maria Beatriz; Bozzini, Carlos Eduardo Jose; Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats; Churchill Livingstone; International Journal Of Oral And Maxillofacial Surgery; 38; 7; 7-2009; 785-7891399-00200901-5027CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ijoms.com/article/S0901-5027(09)00098-8/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijom.2009.03.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:35:02Zoai:ri.conicet.gov.ar:11336/161983instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:35:03.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
title Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
spellingShingle Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
Puia, Sebastian A.
BISMUTH SUBGALLATE
BONE HEALING
HEMOSTATIC AGENT
title_short Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
title_full Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
title_fullStr Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
title_full_unstemmed Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
title_sort Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats
dc.creator.none.fl_str_mv Puia, Sebastian A.
Renou, Sandra Judith
Rey, Eduardo A.
Guglielmotti, Maria Beatriz
Bozzini, Carlos Eduardo Jose
author Puia, Sebastian A.
author_facet Puia, Sebastian A.
Renou, Sandra Judith
Rey, Eduardo A.
Guglielmotti, Maria Beatriz
Bozzini, Carlos Eduardo Jose
author_role author
author2 Renou, Sandra Judith
Rey, Eduardo A.
Guglielmotti, Maria Beatriz
Bozzini, Carlos Eduardo Jose
author2_role author
author
author
author
dc.subject.none.fl_str_mv BISMUTH SUBGALLATE
BONE HEALING
HEMOSTATIC AGENT
topic BISMUTH SUBGALLATE
BONE HEALING
HEMOSTATIC AGENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80 ± 5 g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.
Fil: Puia, Sebastian A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Rey, Eduardo A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
description Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80 ± 5 g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.
publishDate 2009
dc.date.none.fl_str_mv 2009-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161983
Puia, Sebastian A.; Renou, Sandra Judith; Rey, Eduardo A.; Guglielmotti, Maria Beatriz; Bozzini, Carlos Eduardo Jose; Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats; Churchill Livingstone; International Journal Of Oral And Maxillofacial Surgery; 38; 7; 7-2009; 785-789
1399-0020
0901-5027
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161983
identifier_str_mv Puia, Sebastian A.; Renou, Sandra Judith; Rey, Eduardo A.; Guglielmotti, Maria Beatriz; Bozzini, Carlos Eduardo Jose; Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats; Churchill Livingstone; International Journal Of Oral And Maxillofacial Surgery; 38; 7; 7-2009; 785-789
1399-0020
0901-5027
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ijoms.com/article/S0901-5027(09)00098-8/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijom.2009.03.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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