Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
- Autores
- Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; Fernández Mas, Rodrigo; Rocha, Luisa
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.
Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; México
Fil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; México
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Rocha, Luisa. Center for Research and Advanced Studies; México - Materia
-
Cell Damage
Electrographic Activity
Glutamate
Neuronal Excitability
Neuroprotection - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/49566
Ver los metadatos del registro completo
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Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in ratsSantana-Gómez, César EmmanuelOrozco-Suárez, Sandra AdelaTalevi, AlanBruno Blanch, Luis EnriqueMagdaleno Madrigal, Víctor ManuelFernández Mas, RodrigoRocha, LuisaCell DamageElectrographic ActivityGlutamateNeuronal ExcitabilityNeuroprotectionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; MéxicoFil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; MéxicoFil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; MéxicoFil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; MéxicoFil: Rocha, Luisa. Center for Research and Advanced Studies; MéxicoElsevier Science2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49566Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-1200161-813XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2017.01.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0161813X17300207info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:59Zoai:ri.conicet.gov.ar:11336/49566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:59.389CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
title |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
spellingShingle |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats Santana-Gómez, César Emmanuel Cell Damage Electrographic Activity Glutamate Neuronal Excitability Neuroprotection |
title_short |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
title_full |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
title_fullStr |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
title_full_unstemmed |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
title_sort |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats |
dc.creator.none.fl_str_mv |
Santana-Gómez, César Emmanuel Orozco-Suárez, Sandra Adela Talevi, Alan Bruno Blanch, Luis Enrique Magdaleno Madrigal, Víctor Manuel Fernández Mas, Rodrigo Rocha, Luisa |
author |
Santana-Gómez, César Emmanuel |
author_facet |
Santana-Gómez, César Emmanuel Orozco-Suárez, Sandra Adela Talevi, Alan Bruno Blanch, Luis Enrique Magdaleno Madrigal, Víctor Manuel Fernández Mas, Rodrigo Rocha, Luisa |
author_role |
author |
author2 |
Orozco-Suárez, Sandra Adela Talevi, Alan Bruno Blanch, Luis Enrique Magdaleno Madrigal, Víctor Manuel Fernández Mas, Rodrigo Rocha, Luisa |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Cell Damage Electrographic Activity Glutamate Neuronal Excitability Neuroprotection |
topic |
Cell Damage Electrographic Activity Glutamate Neuronal Excitability Neuroprotection |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity. Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; México Fil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; México Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; México Fil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; México Fil: Rocha, Luisa. Center for Research and Advanced Studies; México |
description |
Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/49566 Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-120 0161-813X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/49566 |
identifier_str_mv |
Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-120 0161-813X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2017.01.009 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0161813X17300207 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613518717878272 |
score |
13.070432 |