Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats

Autores
Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; Fernández Mas, Rodrigo; Rocha, Luisa
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.
Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; México
Fil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; México
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Rocha, Luisa. Center for Research and Advanced Studies; México
Materia
Cell Damage
Electrographic Activity
Glutamate
Neuronal Excitability
Neuroprotection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/49566
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in ratsSantana-Gómez, César EmmanuelOrozco-Suárez, Sandra AdelaTalevi, AlanBruno Blanch, Luis EnriqueMagdaleno Madrigal, Víctor ManuelFernández Mas, RodrigoRocha, LuisaCell DamageElectrographic ActivityGlutamateNeuronal ExcitabilityNeuroprotectionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; MéxicoFil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; MéxicoFil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; MéxicoFil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; MéxicoFil: Rocha, Luisa. Center for Research and Advanced Studies; MéxicoElsevier Science2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49566Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-1200161-813XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2017.01.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0161813X17300207info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:18:25Zoai:ri.conicet.gov.ar:11336/49566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:18:25.866CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
title Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
spellingShingle Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
Santana-Gómez, César Emmanuel
Cell Damage
Electrographic Activity
Glutamate
Neuronal Excitability
Neuroprotection
title_short Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
title_full Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
title_fullStr Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
title_full_unstemmed Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
title_sort Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats
dc.creator.none.fl_str_mv Santana-Gómez, César Emmanuel
Orozco-Suárez, Sandra Adela
Talevi, Alan
Bruno Blanch, Luis Enrique
Magdaleno Madrigal, Víctor Manuel
Fernández Mas, Rodrigo
Rocha, Luisa
author Santana-Gómez, César Emmanuel
author_facet Santana-Gómez, César Emmanuel
Orozco-Suárez, Sandra Adela
Talevi, Alan
Bruno Blanch, Luis Enrique
Magdaleno Madrigal, Víctor Manuel
Fernández Mas, Rodrigo
Rocha, Luisa
author_role author
author2 Orozco-Suárez, Sandra Adela
Talevi, Alan
Bruno Blanch, Luis Enrique
Magdaleno Madrigal, Víctor Manuel
Fernández Mas, Rodrigo
Rocha, Luisa
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cell Damage
Electrographic Activity
Glutamate
Neuronal Excitability
Neuroprotection
topic Cell Damage
Electrographic Activity
Glutamate
Neuronal Excitability
Neuroprotection
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.
Fil: Santana-Gómez, César Emmanuel. Center for Research and Advanced Studies; México
Fil: Orozco-Suárez, Sandra Adela. National Medical Center SXXI; México
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Magdaleno Madrigal, Víctor Manuel. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Fernández Mas, Rodrigo. National Institute of Psychiatry Ramon de la Fuente Muñiz; México
Fil: Rocha, Luisa. Center for Research and Advanced Studies; México
description Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1–13 Hz bands, p < 0.001), a reduced potency of 30–250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/49566
Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-120
0161-813X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/49566
identifier_str_mv Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno Blanch, Luis Enrique; Magdaleno Madrigal, Víctor Manuel; et al.; Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats; Elsevier Science; Neurotoxicology; 59; 3-2017; 110-120
0161-813X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2017.01.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0161813X17300207
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781647122333696
score 12.982451

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