Immune Response Modulation by Tumor-Secreted Glycosphingolipids

Autores
Lardone, Ricardo Dante; Cely, Ingrid; Sieling, Peter A.; Lee, Delphine
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL compositioncompared to parental normal cells. These modifications may contribute to both tumor survival and exert strikingeffects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.
Fil: Lardone, Ricardo Dante. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Cely, Ingrid. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
Fil: Sieling, Peter A.. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
Fil: Lee, Delphine. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
Materia
Glycosphingolipids
Anti-tumor immunity
Cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32113
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune Response Modulation by Tumor-Secreted GlycosphingolipidsLardone, Ricardo DanteCely, IngridSieling, Peter A.Lee, DelphineGlycosphingolipidsAnti-tumor immunityCancerhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL compositioncompared to parental normal cells. These modifications may contribute to both tumor survival and exert strikingeffects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.Fil: Lardone, Ricardo Dante. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Cely, Ingrid. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados UnidosFil: Sieling, Peter A.. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados UnidosFil: Lee, Delphine. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados UnidosOmics Group International2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32113Lee, Delphine; Sieling, Peter A.; Cely, Ingrid; Lardone, Ricardo Dante; Immune Response Modulation by Tumor-Secreted Glycosphingolipids; Omics Group International; Journal of Glycobiology; 3; 107; 4-20142168-958XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/immune-response-modulation-by-tumorsecreted-glycosphingolipids-2168-958X-3-107.php?aid=30322info:eu-repo/semantics/altIdentifier/doi/10.4172/2168-958X.1000107info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:01Zoai:ri.conicet.gov.ar:11336/32113instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:01.388CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune Response Modulation by Tumor-Secreted Glycosphingolipids
title Immune Response Modulation by Tumor-Secreted Glycosphingolipids
spellingShingle Immune Response Modulation by Tumor-Secreted Glycosphingolipids
Lardone, Ricardo Dante
Glycosphingolipids
Anti-tumor immunity
Cancer
title_short Immune Response Modulation by Tumor-Secreted Glycosphingolipids
title_full Immune Response Modulation by Tumor-Secreted Glycosphingolipids
title_fullStr Immune Response Modulation by Tumor-Secreted Glycosphingolipids
title_full_unstemmed Immune Response Modulation by Tumor-Secreted Glycosphingolipids
title_sort Immune Response Modulation by Tumor-Secreted Glycosphingolipids
dc.creator.none.fl_str_mv Lardone, Ricardo Dante
Cely, Ingrid
Sieling, Peter A.
Lee, Delphine
author Lardone, Ricardo Dante
author_facet Lardone, Ricardo Dante
Cely, Ingrid
Sieling, Peter A.
Lee, Delphine
author_role author
author2 Cely, Ingrid
Sieling, Peter A.
Lee, Delphine
author2_role author
author
author
dc.subject.none.fl_str_mv Glycosphingolipids
Anti-tumor immunity
Cancer
topic Glycosphingolipids
Anti-tumor immunity
Cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL compositioncompared to parental normal cells. These modifications may contribute to both tumor survival and exert strikingeffects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.
Fil: Lardone, Ricardo Dante. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Cely, Ingrid. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
Fil: Sieling, Peter A.. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
Fil: Lee, Delphine. John Wayne Cancer Institute at Providence Saint John’s Health Center. Santa Monica; Estados Unidos
description Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL compositioncompared to parental normal cells. These modifications may contribute to both tumor survival and exert strikingeffects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32113
Lee, Delphine; Sieling, Peter A.; Cely, Ingrid; Lardone, Ricardo Dante; Immune Response Modulation by Tumor-Secreted Glycosphingolipids; Omics Group International; Journal of Glycobiology; 3; 107; 4-2014
2168-958X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32113
identifier_str_mv Lee, Delphine; Sieling, Peter A.; Cely, Ingrid; Lardone, Ricardo Dante; Immune Response Modulation by Tumor-Secreted Glycosphingolipids; Omics Group International; Journal of Glycobiology; 3; 107; 4-2014
2168-958X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/immune-response-modulation-by-tumorsecreted-glycosphingolipids-2168-958X-3-107.php?aid=30322
info:eu-repo/semantics/altIdentifier/doi/10.4172/2168-958X.1000107
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Omics Group International
publisher.none.fl_str_mv Omics Group International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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