Shelterin genes, germ line mutations and chronic lymphocytic leukemia

Autores
Slavutsky, Irma Rosa
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Telomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progression
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
CHRONIC LYMPHOCYTIC LEUKEMIA
GERM LINE MUTATIONS
SHELTERIN GENES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210768
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Shelterin genes, germ line mutations and chronic lymphocytic leukemiaSlavutsky, Irma RosaCHRONIC LYMPHOCYTIC LEUKEMIAGERM LINE MUTATIONSSHELTERIN GENEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Telomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progressionFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaAME Publishing Company2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210768Slavutsky, Irma Rosa; Shelterin genes, germ line mutations and chronic lymphocytic leukemia; AME Publishing Company; Translational Cancer Research; 6; S1; 2-2017; 68-712219-6803CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tcr.amegroups.org/article/view/12081/10301info:eu-repo/semantics/altIdentifier/doi/10.21037/tcr.2017.02.36info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:57Zoai:ri.conicet.gov.ar:11336/210768instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:57.918CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Shelterin genes, germ line mutations and chronic lymphocytic leukemia
title Shelterin genes, germ line mutations and chronic lymphocytic leukemia
spellingShingle Shelterin genes, germ line mutations and chronic lymphocytic leukemia
Slavutsky, Irma Rosa
CHRONIC LYMPHOCYTIC LEUKEMIA
GERM LINE MUTATIONS
SHELTERIN GENES
title_short Shelterin genes, germ line mutations and chronic lymphocytic leukemia
title_full Shelterin genes, germ line mutations and chronic lymphocytic leukemia
title_fullStr Shelterin genes, germ line mutations and chronic lymphocytic leukemia
title_full_unstemmed Shelterin genes, germ line mutations and chronic lymphocytic leukemia
title_sort Shelterin genes, germ line mutations and chronic lymphocytic leukemia
dc.creator.none.fl_str_mv Slavutsky, Irma Rosa
author Slavutsky, Irma Rosa
author_facet Slavutsky, Irma Rosa
author_role author
dc.subject.none.fl_str_mv CHRONIC LYMPHOCYTIC LEUKEMIA
GERM LINE MUTATIONS
SHELTERIN GENES
topic CHRONIC LYMPHOCYTIC LEUKEMIA
GERM LINE MUTATIONS
SHELTERIN GENES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Telomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progression
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Telomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progression
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210768
Slavutsky, Irma Rosa; Shelterin genes, germ line mutations and chronic lymphocytic leukemia; AME Publishing Company; Translational Cancer Research; 6; S1; 2-2017; 68-71
2219-6803
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210768
identifier_str_mv Slavutsky, Irma Rosa; Shelterin genes, germ line mutations and chronic lymphocytic leukemia; AME Publishing Company; Translational Cancer Research; 6; S1; 2-2017; 68-71
2219-6803
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tcr.amegroups.org/article/view/12081/10301
info:eu-repo/semantics/altIdentifier/doi/10.21037/tcr.2017.02.36
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268893094084608
score 13.13397

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