Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)

Autores
Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; Rodríguez, Casilda
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Materia
BLACK VULTURES
ENROFLOXACIN
MONTE CARLO SIMULATION
PHARMACOKINETIC
PK/PD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162035

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oai_identifier_str oai:ri.conicet.gov.ar:11336/162035
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)Waxman Dova, Samantade Lucas, José JulioWiemeyer, GuillermoTorres Bianchini, LauraSan Andrés, Manuel IgnacioRodríguez, CasildaBLACK VULTURESENROFLOXACINMONTE CARLO SIMULATIONPHARMACOKINETICPK/PDhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaFil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaFil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaMDPI AG2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162035Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-72079-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/8/957info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10080957info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:05Zoai:ri.conicet.gov.ar:11336/162035instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:06.032CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
title Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
spellingShingle Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
Waxman Dova, Samanta
BLACK VULTURES
ENROFLOXACIN
MONTE CARLO SIMULATION
PHARMACOKINETIC
PK/PD
title_short Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
title_full Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
title_fullStr Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
title_full_unstemmed Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
title_sort Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
dc.creator.none.fl_str_mv Waxman Dova, Samanta
de Lucas, José Julio
Wiemeyer, Guillermo
Torres Bianchini, Laura
San Andrés, Manuel Ignacio
Rodríguez, Casilda
author Waxman Dova, Samanta
author_facet Waxman Dova, Samanta
de Lucas, José Julio
Wiemeyer, Guillermo
Torres Bianchini, Laura
San Andrés, Manuel Ignacio
Rodríguez, Casilda
author_role author
author2 de Lucas, José Julio
Wiemeyer, Guillermo
Torres Bianchini, Laura
San Andrés, Manuel Ignacio
Rodríguez, Casilda
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BLACK VULTURES
ENROFLOXACIN
MONTE CARLO SIMULATION
PHARMACOKINETIC
PK/PD
topic BLACK VULTURES
ENROFLOXACIN
MONTE CARLO SIMULATION
PHARMACOKINETIC
PK/PD
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; España
description The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162035
Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-7
2079-6382
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162035
identifier_str_mv Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-7
2079-6382
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/8/957
info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10080957
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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