Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
- Autores
- Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; Rodríguez, Casilda
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; España - Materia
-
BLACK VULTURES
ENROFLOXACIN
MONTE CARLO SIMULATION
PHARMACOKINETIC
PK/PD - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/162035
Ver los metadatos del registro completo
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Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)Waxman Dova, Samantade Lucas, José JulioWiemeyer, GuillermoTorres Bianchini, LauraSan Andrés, Manuel IgnacioRodríguez, CasildaBLACK VULTURESENROFLOXACINMONTE CARLO SIMULATIONPHARMACOKINETICPK/PDhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaFil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaFil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaMDPI AG2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162035Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-72079-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/8/957info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10080957info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:05Zoai:ri.conicet.gov.ar:11336/162035instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:06.032CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
title |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
spellingShingle |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) Waxman Dova, Samanta BLACK VULTURES ENROFLOXACIN MONTE CARLO SIMULATION PHARMACOKINETIC PK/PD |
title_short |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
title_full |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
title_fullStr |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
title_full_unstemmed |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
title_sort |
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus) |
dc.creator.none.fl_str_mv |
Waxman Dova, Samanta de Lucas, José Julio Wiemeyer, Guillermo Torres Bianchini, Laura San Andrés, Manuel Ignacio Rodríguez, Casilda |
author |
Waxman Dova, Samanta |
author_facet |
Waxman Dova, Samanta de Lucas, José Julio Wiemeyer, Guillermo Torres Bianchini, Laura San Andrés, Manuel Ignacio Rodríguez, Casilda |
author_role |
author |
author2 |
de Lucas, José Julio Wiemeyer, Guillermo Torres Bianchini, Laura San Andrés, Manuel Ignacio Rodríguez, Casilda |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
BLACK VULTURES ENROFLOXACIN MONTE CARLO SIMULATION PHARMACOKINETIC PK/PD |
topic |
BLACK VULTURES ENROFLOXACIN MONTE CARLO SIMULATION PHARMACOKINETIC PK/PD |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints. Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; España Fil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España Fil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; España |
description |
The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/162035 Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-7 2079-6382 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/162035 |
identifier_str_mv |
Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-7 2079-6382 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/8/957 info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10080957 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613326636580864 |
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13.070432 |