Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease

Autores
Le Douaron, Gael; Ferrié, Laurent; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine; Acuña, Leonardo; Raisman Vozari, Rita; Michel, Patrick P.; Figadere, Bruno
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.
Fil: Le Douaron, Gael. Universite Paris Sud; Francia. Universite Pierre et Marie Curie; Francia
Fil: Ferrié, Laurent. Universite Paris Sud; Francia
Fil: Sepulveda Diaz, Julia E.. Universite Pierre et Marie Curie; Francia
Fil: Seon Méniel, Blandine. Universite Paris Sud; Francia
Fil: Acuña, Leonardo. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia
Fil: Michel, Patrick P.. Universite Pierre et Marie Curie; Francia
Fil: Figadere, Bruno. Universite Paris Sud; Francia
Materia
Medicinal Chemistry
Neurodegenerative Diseases
Phenotypic Screening
Primary Neuronal Cultures
Suzuki Coupling Reaction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37253
Acceder
id CONICETDig_7bd39a4f01cdfe95271beb6ee6beb776
oai_identifier_str oai:ri.conicet.gov.ar:11336/37253
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's diseaseLe Douaron, GaelFerrié, LaurentSepulveda Diaz, Julia E.Seon Méniel, BlandineAcuña, LeonardoRaisman Vozari, RitaMichel, Patrick P.Figadere, BrunoMedicinal ChemistryNeurodegenerative DiseasesPhenotypic ScreeningPrimary Neuronal CulturesSuzuki Coupling Reactionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.Fil: Le Douaron, Gael. Universite Paris Sud; Francia. Universite Pierre et Marie Curie; FranciaFil: Ferrié, Laurent. Universite Paris Sud; FranciaFil: Sepulveda Diaz, Julia E.. Universite Pierre et Marie Curie; FranciaFil: Seon Méniel, Blandine. Universite Paris Sud; FranciaFil: Acuña, Leonardo. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; FranciaFil: Michel, Patrick P.. Universite Pierre et Marie Curie; FranciaFil: Figadere, Bruno. Universite Paris Sud; FranciaAmerican Chemical Society2017-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37253Le Douaron, Gael; Ferrié, Laurent ; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine ; Acuña, Leonardo; et al.; Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease; American Chemical Society; ACS Chemical Neuroscience; 8; 10; 9-2017; 2347-23471948-7193CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/acschemneuro.7b00352info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acschemneuro.7b00352info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:46:37Zoai:ri.conicet.gov.ar:11336/37253instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:46:37.566CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
title Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
spellingShingle Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
Le Douaron, Gael
Medicinal Chemistry
Neurodegenerative Diseases
Phenotypic Screening
Primary Neuronal Cultures
Suzuki Coupling Reaction
title_short Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
title_full Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
title_fullStr Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
title_full_unstemmed Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
title_sort Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
dc.creator.none.fl_str_mv Le Douaron, Gael
Ferrié, Laurent
Sepulveda Diaz, Julia E.
Seon Méniel, Blandine
Acuña, Leonardo
Raisman Vozari, Rita
Michel, Patrick P.
Figadere, Bruno
author Le Douaron, Gael
author_facet Le Douaron, Gael
Ferrié, Laurent
Sepulveda Diaz, Julia E.
Seon Méniel, Blandine
Acuña, Leonardo
Raisman Vozari, Rita
Michel, Patrick P.
Figadere, Bruno
author_role author
author2 Ferrié, Laurent
Sepulveda Diaz, Julia E.
Seon Méniel, Blandine
Acuña, Leonardo
Raisman Vozari, Rita
Michel, Patrick P.
Figadere, Bruno
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Medicinal Chemistry
Neurodegenerative Diseases
Phenotypic Screening
Primary Neuronal Cultures
Suzuki Coupling Reaction
topic Medicinal Chemistry
Neurodegenerative Diseases
Phenotypic Screening
Primary Neuronal Cultures
Suzuki Coupling Reaction
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.
Fil: Le Douaron, Gael. Universite Paris Sud; Francia. Universite Pierre et Marie Curie; Francia
Fil: Ferrié, Laurent. Universite Paris Sud; Francia
Fil: Sepulveda Diaz, Julia E.. Universite Pierre et Marie Curie; Francia
Fil: Seon Méniel, Blandine. Universite Paris Sud; Francia
Fil: Acuña, Leonardo. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia
Fil: Michel, Patrick P.. Universite Pierre et Marie Curie; Francia
Fil: Figadere, Bruno. Universite Paris Sud; Francia
description Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37253
Le Douaron, Gael; Ferrié, Laurent ; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine ; Acuña, Leonardo; et al.; Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease; American Chemical Society; ACS Chemical Neuroscience; 8; 10; 9-2017; 2347-2347
1948-7193
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37253
identifier_str_mv Le Douaron, Gael; Ferrié, Laurent ; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine ; Acuña, Leonardo; et al.; Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease; American Chemical Society; ACS Chemical Neuroscience; 8; 10; 9-2017; 2347-2347
1948-7193
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/acschemneuro.7b00352
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acschemneuro.7b00352
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782168697667584
score 12.982451

Publicaciones similares