A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile

Autores
Vigliecca, Nora Silvana; Molina, Silvia Cristina; Peñalva, Marisa Carola
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Clinical studies have shown that some antidepressants may be more efficient than benzodiazepines to alleviate anxiety associated with panic disorders; however, operant conflict procedures in rats developed so far seem not particularly able to model human anxiety sensitive to antidepressant treatments. Previous panic models with learned responses did not statistically subtract the effect of confounding factors from the variable of interest. Methods: Undernourished rats were selected due to their behavioral and neurobiological resemblance to human patients suffering from panic disorder. The Geller–Seifter paradigm represented the stressful environmental condition in adult life. Desipramine (10 mg/kg/day) or saline were administered IP during 7 days under a cross over design (N= 10). Five daily 15 min-operant sessions were carried out on each experiment. Unpunished, unrewarded and punished operant behavioral periods were identical both in their duration and in their reward system (the FR1 schedule) in order to measure response suppression, which has not been considered in previous studies with the Geller–Seifter paradigm. The dependent variable was the difference between comparable unpunished and punished periods. Results: A significant Diet × Drug interaction was observed in the dependent variable, which represented the level of “suppression/suppression release” induced by treatments. Discussion: Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller–Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.
Fil: Vigliecca, Nora Silvana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molina, Silvia Cristina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
Fil: Peñalva, Marisa Carola. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
Materia
Methodology
Pharmacology
Behavioral
Cognition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25179
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/25179
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profileVigliecca, Nora SilvanaMolina, Silvia CristinaPeñalva, Marisa CarolaMethodologyPharmacologyBehavioralCognitionhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Introduction: Clinical studies have shown that some antidepressants may be more efficient than benzodiazepines to alleviate anxiety associated with panic disorders; however, operant conflict procedures in rats developed so far seem not particularly able to model human anxiety sensitive to antidepressant treatments. Previous panic models with learned responses did not statistically subtract the effect of confounding factors from the variable of interest. Methods: Undernourished rats were selected due to their behavioral and neurobiological resemblance to human patients suffering from panic disorder. The Geller–Seifter paradigm represented the stressful environmental condition in adult life. Desipramine (10 mg/kg/day) or saline were administered IP during 7 days under a cross over design (N= 10). Five daily 15 min-operant sessions were carried out on each experiment. Unpunished, unrewarded and punished operant behavioral periods were identical both in their duration and in their reward system (the FR1 schedule) in order to measure response suppression, which has not been considered in previous studies with the Geller–Seifter paradigm. The dependent variable was the difference between comparable unpunished and punished periods. Results: A significant Diet × Drug interaction was observed in the dependent variable, which represented the level of “suppression/suppression release” induced by treatments. Discussion: Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller–Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.Fil: Vigliecca, Nora Silvana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Molina, Silvia Cristina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; ArgentinaFil: Peñalva, Marisa Carola. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; ArgentinaElsevier Inc2006-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25179Vigliecca, Nora Silvana; Molina, Silvia Cristina; Peñalva, Marisa Carola; A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile; Elsevier Inc; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 2-2006; 49-571056-8719CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vascn.2006.02.008info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1056871906000256info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:21Zoai:ri.conicet.gov.ar:11336/25179instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:21.624CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
title A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
spellingShingle A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
Vigliecca, Nora Silvana
Methodology
Pharmacology
Behavioral
Cognition
title_short A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
title_full A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
title_fullStr A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
title_full_unstemmed A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
title_sort A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
dc.creator.none.fl_str_mv Vigliecca, Nora Silvana
Molina, Silvia Cristina
Peñalva, Marisa Carola
author Vigliecca, Nora Silvana
author_facet Vigliecca, Nora Silvana
Molina, Silvia Cristina
Peñalva, Marisa Carola
author_role author
author2 Molina, Silvia Cristina
Peñalva, Marisa Carola
author2_role author
author
dc.subject.none.fl_str_mv Methodology
Pharmacology
Behavioral
Cognition
topic Methodology
Pharmacology
Behavioral
Cognition
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Introduction: Clinical studies have shown that some antidepressants may be more efficient than benzodiazepines to alleviate anxiety associated with panic disorders; however, operant conflict procedures in rats developed so far seem not particularly able to model human anxiety sensitive to antidepressant treatments. Previous panic models with learned responses did not statistically subtract the effect of confounding factors from the variable of interest. Methods: Undernourished rats were selected due to their behavioral and neurobiological resemblance to human patients suffering from panic disorder. The Geller–Seifter paradigm represented the stressful environmental condition in adult life. Desipramine (10 mg/kg/day) or saline were administered IP during 7 days under a cross over design (N= 10). Five daily 15 min-operant sessions were carried out on each experiment. Unpunished, unrewarded and punished operant behavioral periods were identical both in their duration and in their reward system (the FR1 schedule) in order to measure response suppression, which has not been considered in previous studies with the Geller–Seifter paradigm. The dependent variable was the difference between comparable unpunished and punished periods. Results: A significant Diet × Drug interaction was observed in the dependent variable, which represented the level of “suppression/suppression release” induced by treatments. Discussion: Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller–Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.
Fil: Vigliecca, Nora Silvana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molina, Silvia Cristina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
Fil: Peñalva, Marisa Carola. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
description Introduction: Clinical studies have shown that some antidepressants may be more efficient than benzodiazepines to alleviate anxiety associated with panic disorders; however, operant conflict procedures in rats developed so far seem not particularly able to model human anxiety sensitive to antidepressant treatments. Previous panic models with learned responses did not statistically subtract the effect of confounding factors from the variable of interest. Methods: Undernourished rats were selected due to their behavioral and neurobiological resemblance to human patients suffering from panic disorder. The Geller–Seifter paradigm represented the stressful environmental condition in adult life. Desipramine (10 mg/kg/day) or saline were administered IP during 7 days under a cross over design (N= 10). Five daily 15 min-operant sessions were carried out on each experiment. Unpunished, unrewarded and punished operant behavioral periods were identical both in their duration and in their reward system (the FR1 schedule) in order to measure response suppression, which has not been considered in previous studies with the Geller–Seifter paradigm. The dependent variable was the difference between comparable unpunished and punished periods. Results: A significant Diet × Drug interaction was observed in the dependent variable, which represented the level of “suppression/suppression release” induced by treatments. Discussion: Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller–Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.
publishDate 2006
dc.date.none.fl_str_mv 2006-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25179
Vigliecca, Nora Silvana; Molina, Silvia Cristina; Peñalva, Marisa Carola; A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile; Elsevier Inc; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 2-2006; 49-57
1056-8719
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25179
identifier_str_mv Vigliecca, Nora Silvana; Molina, Silvia Cristina; Peñalva, Marisa Carola; A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile; Elsevier Inc; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 2-2006; 49-57
1056-8719
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vascn.2006.02.008
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1056871906000256
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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