Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications

Autores
Mascanfroni, Ivan Darío; Cerliani, Juan Pablo; Dergan Dylon, Leonardo Sebastian; Croci Russo, Diego Omar; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg) cells. Several factors may influence the ‘decision’ of DCs to become immunogenic or tolerogenic including the nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive immune responses, through recognition of specific ‘glycan signatures’ on invading pathogens or host cells. While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins converge in similar functional outcomes regardless of divergences in their structure, homology or glycanbinding specificity. To gain a more complete understanding on the role of protein–glycan interactions in DC biology, here we will integrate scattered information on these structurally-divergent but functionally-related lectins and their potential biomedical applications.
Fil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Ilarregui, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
Lectins
Galectins
C-Type Lectins
Siglecs
Dendritic Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11670
Acceder
id CONICETDig_7b7243b6de7565d32a531dc6de10c896
oai_identifier_str oai:ri.conicet.gov.ar:11336/11670
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applicationsMascanfroni, Ivan DaríoCerliani, Juan PabloDergan Dylon, Leonardo SebastianCroci Russo, Diego OmarIlarregui, Juan MartinRabinovich, Gabriel AdriánLectinsGalectinsC-Type LectinsSiglecsDendritic Cellshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg) cells. Several factors may influence the ‘decision’ of DCs to become immunogenic or tolerogenic including the nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive immune responses, through recognition of specific ‘glycan signatures’ on invading pathogens or host cells. While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins converge in similar functional outcomes regardless of divergences in their structure, homology or glycanbinding specificity. To gain a more complete understanding on the role of protein–glycan interactions in DC biology, here we will integrate scattered information on these structurally-divergent but functionally-related lectins and their potential biomedical applications.Fil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Ilarregui, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaElsevier Science2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11670Mascanfroni, Ivan Darío; Cerliani, Juan Pablo; Dergan Dylon, Leonardo Sebastian; Croci Russo, Diego Omar; Ilarregui, Juan Martin; et al.; Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications; Elsevier Science; International Immunopharmacology; 11; 7; 7-2011; 833-8411567-5769enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567576911000567info:eu-repo/semantics/altIdentifier/doi/10.1016/j.intimp.2011.01.021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:30Zoai:ri.conicet.gov.ar:11336/11670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:31.008CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
title Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
spellingShingle Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
Mascanfroni, Ivan Darío
Lectins
Galectins
C-Type Lectins
Siglecs
Dendritic Cells
title_short Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
title_full Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
title_fullStr Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
title_full_unstemmed Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
title_sort Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
dc.creator.none.fl_str_mv Mascanfroni, Ivan Darío
Cerliani, Juan Pablo
Dergan Dylon, Leonardo Sebastian
Croci Russo, Diego Omar
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author Mascanfroni, Ivan Darío
author_facet Mascanfroni, Ivan Darío
Cerliani, Juan Pablo
Dergan Dylon, Leonardo Sebastian
Croci Russo, Diego Omar
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author_role author
author2 Cerliani, Juan Pablo
Dergan Dylon, Leonardo Sebastian
Croci Russo, Diego Omar
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lectins
Galectins
C-Type Lectins
Siglecs
Dendritic Cells
topic Lectins
Galectins
C-Type Lectins
Siglecs
Dendritic Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg) cells. Several factors may influence the ‘decision’ of DCs to become immunogenic or tolerogenic including the nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive immune responses, through recognition of specific ‘glycan signatures’ on invading pathogens or host cells. While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins converge in similar functional outcomes regardless of divergences in their structure, homology or glycanbinding specificity. To gain a more complete understanding on the role of protein–glycan interactions in DC biology, here we will integrate scattered information on these structurally-divergent but functionally-related lectins and their potential biomedical applications.
Fil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Ilarregui, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg) cells. Several factors may influence the ‘decision’ of DCs to become immunogenic or tolerogenic including the nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive immune responses, through recognition of specific ‘glycan signatures’ on invading pathogens or host cells. While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins converge in similar functional outcomes regardless of divergences in their structure, homology or glycanbinding specificity. To gain a more complete understanding on the role of protein–glycan interactions in DC biology, here we will integrate scattered information on these structurally-divergent but functionally-related lectins and their potential biomedical applications.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11670
Mascanfroni, Ivan Darío; Cerliani, Juan Pablo; Dergan Dylon, Leonardo Sebastian; Croci Russo, Diego Omar; Ilarregui, Juan Martin; et al.; Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications; Elsevier Science; International Immunopharmacology; 11; 7; 7-2011; 833-841
1567-5769
url http://hdl.handle.net/11336/11670
identifier_str_mv Mascanfroni, Ivan Darío; Cerliani, Juan Pablo; Dergan Dylon, Leonardo Sebastian; Croci Russo, Diego Omar; Ilarregui, Juan Martin; et al.; Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications; Elsevier Science; International Immunopharmacology; 11; 7; 7-2011; 833-841
1567-5769
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567576911000567
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.intimp.2011.01.021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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