Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin

Autores
Mantero, Paula; Matus, Gonzalo Sebastián; Corti, Rodolfo Ernesto; Cabanne, Ana María; Zerbetto de Palma, Gerardo Gabriel; Marchesi Olid, Liliana Soledad; Piskorz, María Marta; Zubillaga, Marcela Beatriz; Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
AIM To evaluate the association of Helicobacter pylori (H. pylori ), cagA genotype, and type of gastric pathology with ghrelin, leptin and nutritional status. METHODS Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using X 2 , Mann-Whitney U , Kruskal-Wallis tests, Spearman´s correlation and linear regression. RESULTS one hundred and sixty-Three patients (40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4% (95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/mL (IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/mL (IQR 253.8-547.8)] (P = 0.025), even after adjusting for BMI and gender (P = 0.03). Ghrelin levels tended to be lower in patients carrying cagA positive strains both in the antrum and the corpus; however, differences with those carrying cagA negative strains did not reach statistical significance (P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin (P = 0.04), independently of H. pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/mL (0.80-4.85) vs 1.84 ng/mL (0.50-5.09), (P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cagA-positive patients.
Fil: Mantero, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Matus, Gonzalo Sebastián. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Corti, Rodolfo Ernesto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Cabanne, Ana María. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Zerbetto de Palma, Gerardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Piskorz, María Marta. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
HELICOBACTER PYLORI
CAGA
GHRELIN
LEPTIN
PATHOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155678
Acceder
id CONICETDig_7adf4301289203816ce5cdaff37716e2
oai_identifier_str oai:ri.conicet.gov.ar:11336/155678
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelinMantero, PaulaMatus, Gonzalo SebastiánCorti, Rodolfo ErnestoCabanne, Ana MaríaZerbetto de Palma, Gerardo GabrielMarchesi Olid, Liliana SoledadPiskorz, María MartaZubillaga, Marcela BeatrizJanjetic, Mariana AndreaGoldman, Cinthia GabrielaHELICOBACTER PYLORICAGAGHRELINLEPTINPATHOLOGYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3AIM To evaluate the association of Helicobacter pylori (H. pylori ), cagA genotype, and type of gastric pathology with ghrelin, leptin and nutritional status. METHODS Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using X 2 , Mann-Whitney U , Kruskal-Wallis tests, Spearman´s correlation and linear regression. RESULTS one hundred and sixty-Three patients (40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4% (95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/mL (IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/mL (IQR 253.8-547.8)] (P = 0.025), even after adjusting for BMI and gender (P = 0.03). Ghrelin levels tended to be lower in patients carrying cagA positive strains both in the antrum and the corpus; however, differences with those carrying cagA negative strains did not reach statistical significance (P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin (P = 0.04), independently of H. pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/mL (0.80-4.85) vs 1.84 ng/mL (0.50-5.09), (P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cagA-positive patients.Fil: Mantero, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Matus, Gonzalo Sebastián. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Corti, Rodolfo Ernesto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Cabanne, Ana María. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Zerbetto de Palma, Gerardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; ArgentinaFil: Piskorz, María Marta. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaW J G Press2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155678Mantero, Paula; Matus, Gonzalo Sebastián; Corti, Rodolfo Ernesto; Cabanne, Ana María; Zerbetto de Palma, Gerardo Gabriel; et al.; Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin; W J G Press; World Journal of Gastroenterology; 24; 3; 1-2018; 397-4072219-28402219-2840CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v24/i3/397.htminfo:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v24.i3.397info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:46:05Zoai:ri.conicet.gov.ar:11336/155678instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:46:05.75CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
title Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
spellingShingle Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
Mantero, Paula
HELICOBACTER PYLORI
CAGA
GHRELIN
LEPTIN
PATHOLOGY
title_short Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
title_full Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
title_fullStr Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
title_full_unstemmed Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
title_sort Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
dc.creator.none.fl_str_mv Mantero, Paula
Matus, Gonzalo Sebastián
Corti, Rodolfo Ernesto
Cabanne, Ana María
Zerbetto de Palma, Gerardo Gabriel
Marchesi Olid, Liliana Soledad
Piskorz, María Marta
Zubillaga, Marcela Beatriz
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author Mantero, Paula
author_facet Mantero, Paula
Matus, Gonzalo Sebastián
Corti, Rodolfo Ernesto
Cabanne, Ana María
Zerbetto de Palma, Gerardo Gabriel
Marchesi Olid, Liliana Soledad
Piskorz, María Marta
Zubillaga, Marcela Beatriz
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author_role author
author2 Matus, Gonzalo Sebastián
Corti, Rodolfo Ernesto
Cabanne, Ana María
Zerbetto de Palma, Gerardo Gabriel
Marchesi Olid, Liliana Soledad
Piskorz, María Marta
Zubillaga, Marcela Beatriz
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HELICOBACTER PYLORI
CAGA
GHRELIN
LEPTIN
PATHOLOGY
topic HELICOBACTER PYLORI
CAGA
GHRELIN
LEPTIN
PATHOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv AIM To evaluate the association of Helicobacter pylori (H. pylori ), cagA genotype, and type of gastric pathology with ghrelin, leptin and nutritional status. METHODS Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using X 2 , Mann-Whitney U , Kruskal-Wallis tests, Spearman´s correlation and linear regression. RESULTS one hundred and sixty-Three patients (40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4% (95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/mL (IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/mL (IQR 253.8-547.8)] (P = 0.025), even after adjusting for BMI and gender (P = 0.03). Ghrelin levels tended to be lower in patients carrying cagA positive strains both in the antrum and the corpus; however, differences with those carrying cagA negative strains did not reach statistical significance (P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin (P = 0.04), independently of H. pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/mL (0.80-4.85) vs 1.84 ng/mL (0.50-5.09), (P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cagA-positive patients.
Fil: Mantero, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Matus, Gonzalo Sebastián. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Corti, Rodolfo Ernesto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Cabanne, Ana María. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Zerbetto de Palma, Gerardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Piskorz, María Marta. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description AIM To evaluate the association of Helicobacter pylori (H. pylori ), cagA genotype, and type of gastric pathology with ghrelin, leptin and nutritional status. METHODS Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using X 2 , Mann-Whitney U , Kruskal-Wallis tests, Spearman´s correlation and linear regression. RESULTS one hundred and sixty-Three patients (40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4% (95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/mL (IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/mL (IQR 253.8-547.8)] (P = 0.025), even after adjusting for BMI and gender (P = 0.03). Ghrelin levels tended to be lower in patients carrying cagA positive strains both in the antrum and the corpus; however, differences with those carrying cagA negative strains did not reach statistical significance (P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin (P = 0.04), independently of H. pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/mL (0.80-4.85) vs 1.84 ng/mL (0.50-5.09), (P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cagA-positive patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155678
Mantero, Paula; Matus, Gonzalo Sebastián; Corti, Rodolfo Ernesto; Cabanne, Ana María; Zerbetto de Palma, Gerardo Gabriel; et al.; Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin; W J G Press; World Journal of Gastroenterology; 24; 3; 1-2018; 397-407
2219-2840
2219-2840
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155678
identifier_str_mv Mantero, Paula; Matus, Gonzalo Sebastián; Corti, Rodolfo Ernesto; Cabanne, Ana María; Zerbetto de Palma, Gerardo Gabriel; et al.; Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin; W J G Press; World Journal of Gastroenterology; 24; 3; 1-2018; 397-407
2219-2840
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v24/i3/397.htm
info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v24.i3.397
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv W J G Press
publisher.none.fl_str_mv W J G Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083559061716992
score 13.22299

Publicaciones similares