Decreased serum ghrelin following Helicobacter pylori eradication

Autores
Mantero, P.; Marchesi Olid, Liliana Soledad; Giacomantone, C.; Cabanne, Ana; Zubillaga, Marcela Beatriz; Blaser, M .J.; Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Ghrelin is an appetite-modulating peptide mainly produced in the stomach, with levels reported to be lower in Helicobacter pylori-positive subjects. This pre-post study aimed to evaluate the effect of H. pylori eradication on circulating total ghrelin, gastric histopathology, appetite, and nutritional status of dyspeptic adults.Patients and Methods: Weight, height, appetite and nutrient intake were determined using validated tools. Gastric biopsies were obtained for histopathology and H. pylori diagnosis. Fasting serum ghrelin was measured by ELISA. H. pylori-positive subjects received eradication therapy and returned ≥12 weeks later for re-evaluation.Results: Of 117 screened individuals, 47 who were H. pylori-positive were included, and the organism was eradicated in 28 (59.6%). Pathologic findings decreased significantly after treatment in subjects with eradication (p<0.0001) but did not in those without. Appetite and nutrient intake did not differ significantly after therapy in either group; however, body weight increased in both (p=0.02 and p=0.03). Fasting serum ghrelin significantly decreased in subjects with eradication [345.0 pg/mL (IQR 373.0-517.8) before, 298.5 pg/mL (IQR 251.0-383.5) after; p=0.0007] but remained unchanged in those without. Conclusions: The decrease in fasting ghrelin after H. pylori eradication indicates its involvement in the regulation of this hormone, which may be mediated by the inflammatory responses in tissues to the organism.
Fil: Mantero, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Giacomantone, C.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Cabanne, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Blaser, M .J.. Rutgers University; Estados Unidos
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Materia
HELICOBACTER PYLORI
GHRELIN
ERADICATION
GASTRIC PATHOLOGY
NUTRITIONAL STATUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225458
Acceder
id CONICETDig_550edca494aa289e8ce95089e503ac31
oai_identifier_str oai:ri.conicet.gov.ar:11336/225458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decreased serum ghrelin following Helicobacter pylori eradicationMantero, P.Marchesi Olid, Liliana SoledadGiacomantone, C.Cabanne, AnaZubillaga, Marcela BeatrizBlaser, M .J.Janjetic, Mariana AndreaGoldman, Cinthia GabrielaHELICOBACTER PYLORIGHRELINERADICATIONGASTRIC PATHOLOGYNUTRITIONAL STATUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: Ghrelin is an appetite-modulating peptide mainly produced in the stomach, with levels reported to be lower in Helicobacter pylori-positive subjects. This pre-post study aimed to evaluate the effect of H. pylori eradication on circulating total ghrelin, gastric histopathology, appetite, and nutritional status of dyspeptic adults.Patients and Methods: Weight, height, appetite and nutrient intake were determined using validated tools. Gastric biopsies were obtained for histopathology and H. pylori diagnosis. Fasting serum ghrelin was measured by ELISA. H. pylori-positive subjects received eradication therapy and returned ≥12 weeks later for re-evaluation.Results: Of 117 screened individuals, 47 who were H. pylori-positive were included, and the organism was eradicated in 28 (59.6%). Pathologic findings decreased significantly after treatment in subjects with eradication (p<0.0001) but did not in those without. Appetite and nutrient intake did not differ significantly after therapy in either group; however, body weight increased in both (p=0.02 and p=0.03). Fasting serum ghrelin significantly decreased in subjects with eradication [345.0 pg/mL (IQR 373.0-517.8) before, 298.5 pg/mL (IQR 251.0-383.5) after; p=0.0007] but remained unchanged in those without. Conclusions: The decrease in fasting ghrelin after H. pylori eradication indicates its involvement in the regulation of this hormone, which may be mediated by the inflammatory responses in tissues to the organism.Fil: Mantero, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; ArgentinaFil: Giacomantone, C.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Cabanne, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Blaser, M .J.. Rutgers University; Estados UnidosFil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaFil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; ArgentinaVerduci Publisher2023-11-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225458Mantero, P.; Marchesi Olid, Liliana Soledad; Giacomantone, C.; Cabanne, Ana; Zubillaga, Marcela Beatriz; et al.; Decreased serum ghrelin following Helicobacter pylori eradication; Verduci Publisher; Microbiota in Health and Disease; 23-11-2023; 1-102704-8845CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.microbiotajournal.com/wp-content/uploads/sites/7/2023/11/e950.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.26355/mhd_202311_950info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:38Zoai:ri.conicet.gov.ar:11336/225458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:38.668CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decreased serum ghrelin following Helicobacter pylori eradication
title Decreased serum ghrelin following Helicobacter pylori eradication
spellingShingle Decreased serum ghrelin following Helicobacter pylori eradication
Mantero, P.
HELICOBACTER PYLORI
GHRELIN
ERADICATION
GASTRIC PATHOLOGY
NUTRITIONAL STATUS
title_short Decreased serum ghrelin following Helicobacter pylori eradication
title_full Decreased serum ghrelin following Helicobacter pylori eradication
title_fullStr Decreased serum ghrelin following Helicobacter pylori eradication
title_full_unstemmed Decreased serum ghrelin following Helicobacter pylori eradication
title_sort Decreased serum ghrelin following Helicobacter pylori eradication
dc.creator.none.fl_str_mv Mantero, P.
Marchesi Olid, Liliana Soledad
Giacomantone, C.
Cabanne, Ana
Zubillaga, Marcela Beatriz
Blaser, M .J.
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author Mantero, P.
author_facet Mantero, P.
Marchesi Olid, Liliana Soledad
Giacomantone, C.
Cabanne, Ana
Zubillaga, Marcela Beatriz
Blaser, M .J.
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author_role author
author2 Marchesi Olid, Liliana Soledad
Giacomantone, C.
Cabanne, Ana
Zubillaga, Marcela Beatriz
Blaser, M .J.
Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HELICOBACTER PYLORI
GHRELIN
ERADICATION
GASTRIC PATHOLOGY
NUTRITIONAL STATUS
topic HELICOBACTER PYLORI
GHRELIN
ERADICATION
GASTRIC PATHOLOGY
NUTRITIONAL STATUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: Ghrelin is an appetite-modulating peptide mainly produced in the stomach, with levels reported to be lower in Helicobacter pylori-positive subjects. This pre-post study aimed to evaluate the effect of H. pylori eradication on circulating total ghrelin, gastric histopathology, appetite, and nutritional status of dyspeptic adults.Patients and Methods: Weight, height, appetite and nutrient intake were determined using validated tools. Gastric biopsies were obtained for histopathology and H. pylori diagnosis. Fasting serum ghrelin was measured by ELISA. H. pylori-positive subjects received eradication therapy and returned ≥12 weeks later for re-evaluation.Results: Of 117 screened individuals, 47 who were H. pylori-positive were included, and the organism was eradicated in 28 (59.6%). Pathologic findings decreased significantly after treatment in subjects with eradication (p<0.0001) but did not in those without. Appetite and nutrient intake did not differ significantly after therapy in either group; however, body weight increased in both (p=0.02 and p=0.03). Fasting serum ghrelin significantly decreased in subjects with eradication [345.0 pg/mL (IQR 373.0-517.8) before, 298.5 pg/mL (IQR 251.0-383.5) after; p=0.0007] but remained unchanged in those without. Conclusions: The decrease in fasting ghrelin after H. pylori eradication indicates its involvement in the regulation of this hormone, which may be mediated by the inflammatory responses in tissues to the organism.
Fil: Mantero, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Marchesi Olid, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Giacomantone, C.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Cabanne, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Blaser, M .J.. Rutgers University; Estados Unidos
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática. Cátedra de Física; Argentina
description Objective: Ghrelin is an appetite-modulating peptide mainly produced in the stomach, with levels reported to be lower in Helicobacter pylori-positive subjects. This pre-post study aimed to evaluate the effect of H. pylori eradication on circulating total ghrelin, gastric histopathology, appetite, and nutritional status of dyspeptic adults.Patients and Methods: Weight, height, appetite and nutrient intake were determined using validated tools. Gastric biopsies were obtained for histopathology and H. pylori diagnosis. Fasting serum ghrelin was measured by ELISA. H. pylori-positive subjects received eradication therapy and returned ≥12 weeks later for re-evaluation.Results: Of 117 screened individuals, 47 who were H. pylori-positive were included, and the organism was eradicated in 28 (59.6%). Pathologic findings decreased significantly after treatment in subjects with eradication (p<0.0001) but did not in those without. Appetite and nutrient intake did not differ significantly after therapy in either group; however, body weight increased in both (p=0.02 and p=0.03). Fasting serum ghrelin significantly decreased in subjects with eradication [345.0 pg/mL (IQR 373.0-517.8) before, 298.5 pg/mL (IQR 251.0-383.5) after; p=0.0007] but remained unchanged in those without. Conclusions: The decrease in fasting ghrelin after H. pylori eradication indicates its involvement in the regulation of this hormone, which may be mediated by the inflammatory responses in tissues to the organism.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225458
Mantero, P.; Marchesi Olid, Liliana Soledad; Giacomantone, C.; Cabanne, Ana; Zubillaga, Marcela Beatriz; et al.; Decreased serum ghrelin following Helicobacter pylori eradication; Verduci Publisher; Microbiota in Health and Disease; 23-11-2023; 1-10
2704-8845
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225458
identifier_str_mv Mantero, P.; Marchesi Olid, Liliana Soledad; Giacomantone, C.; Cabanne, Ana; Zubillaga, Marcela Beatriz; et al.; Decreased serum ghrelin following Helicobacter pylori eradication; Verduci Publisher; Microbiota in Health and Disease; 23-11-2023; 1-10
2704-8845
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.microbiotajournal.com/wp-content/uploads/sites/7/2023/11/e950.pdf
info:eu-repo/semantics/altIdentifier/doi/10.26355/mhd_202311_950
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Verduci Publisher
publisher.none.fl_str_mv Verduci Publisher
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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