ADP-ribosylation: From molecular mechanisms to human disease
- Autores
- Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
Fil: Hoch, Nicolas Carlos. Universidade de Sao Paulo; Brasil
Fil: Polo Ilacqua, Luis Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. University of Sussex; Reino Unido - Materia
-
ADP RIBOSE
DNA DAMAGE RESPONSE
DNA REPAIR
PARP
PARTHANATOS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
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- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/115088
Ver los metadatos del registro completo
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ADP-ribosylation: From molecular mechanisms to human diseaseHoch, Nicolas CarlosPolo Ilacqua, Luis MarianoADP RIBOSEDNA DAMAGE RESPONSEDNA REPAIRPARPPARTHANATOShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.Fil: Hoch, Nicolas Carlos. Universidade de Sao Paulo; BrasilFil: Polo Ilacqua, Luis Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. University of Sussex; Reino UnidoSociedade Brasileira de Genética2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115088Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-141415-47571678-4685CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304&lng=en&nrm=isoinfo:eu-repo/semantics/altIdentifier/doi/10.1590/1678-4685-gmb-2019-0075info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198025/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:51:37Zoai:ri.conicet.gov.ar:11336/115088instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:51:37.727CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
ADP-ribosylation: From molecular mechanisms to human disease |
| title |
ADP-ribosylation: From molecular mechanisms to human disease |
| spellingShingle |
ADP-ribosylation: From molecular mechanisms to human disease Hoch, Nicolas Carlos ADP RIBOSE DNA DAMAGE RESPONSE DNA REPAIR PARP PARTHANATOS |
| title_short |
ADP-ribosylation: From molecular mechanisms to human disease |
| title_full |
ADP-ribosylation: From molecular mechanisms to human disease |
| title_fullStr |
ADP-ribosylation: From molecular mechanisms to human disease |
| title_full_unstemmed |
ADP-ribosylation: From molecular mechanisms to human disease |
| title_sort |
ADP-ribosylation: From molecular mechanisms to human disease |
| dc.creator.none.fl_str_mv |
Hoch, Nicolas Carlos Polo Ilacqua, Luis Mariano |
| author |
Hoch, Nicolas Carlos |
| author_facet |
Hoch, Nicolas Carlos Polo Ilacqua, Luis Mariano |
| author_role |
author |
| author2 |
Polo Ilacqua, Luis Mariano |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
ADP RIBOSE DNA DAMAGE RESPONSE DNA REPAIR PARP PARTHANATOS |
| topic |
ADP RIBOSE DNA DAMAGE RESPONSE DNA REPAIR PARP PARTHANATOS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. Fil: Hoch, Nicolas Carlos. Universidade de Sao Paulo; Brasil Fil: Polo Ilacqua, Luis Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. University of Sussex; Reino Unido |
| description |
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. |
| publishDate |
2020 |
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2020-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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http://hdl.handle.net/11336/115088 Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-14 1415-4757 1678-4685 CONICET Digital CONICET |
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http://hdl.handle.net/11336/115088 |
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Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-14 1415-4757 1678-4685 CONICET Digital CONICET |
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eng |
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eng |
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