Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports

Autores
Fernandez, Ivana Cristina; Camberos, Maria del Carmen; Passicot, Gisel Anabel; Martucci, Lucia Camila; Cresto, Juan Carlos
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Patients: Nine out of seventy healthy participants of the type 1 diabetes risk study were treated. They were typified for diabetes with HLA-DQB1 and positive autoantibodies. Children with a first peak of insulin response ≤ 48 μU were randomly distributed in control and treated patients. Children evolution was followed with an intravenous glucose tolerance test. Control children were treated when was another risk parameter was added. During their evolution all children were treated. Results: Treatment periods differ (range: 120–16 months) because children began treatment at different times. During the treatment 4 patients recovered their parameters and the medication was suspended; 2 patients continued the treatment with favorable evolution. Two children evolved slowly with normal growth and development. One girl became diabetic because she was treated late. Conclusion: In children at risk, this treatment delays the development or remits the evolution of type 1 diabetes.
Fil: Fernandez, Ivana Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Passicot, Gisel Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Martucci, Lucia Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Materia
Acetyl-L- carnitine plus nicotinamide treatment
Patients at risk for type I diabetes
Longitudinal study
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/275046
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/275046
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reportsFernandez, Ivana CristinaCamberos, Maria del CarmenPassicot, Gisel AnabelMartucci, Lucia CamilaCresto, Juan CarlosAcetyl-L- carnitine plus nicotinamide treatmentPatients at risk for type I diabetesLongitudinal studyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Patients: Nine out of seventy healthy participants of the type 1 diabetes risk study were treated. They were typified for diabetes with HLA-DQB1 and positive autoantibodies. Children with a first peak of insulin response ≤ 48 μU were randomly distributed in control and treated patients. Children evolution was followed with an intravenous glucose tolerance test. Control children were treated when was another risk parameter was added. During their evolution all children were treated. Results: Treatment periods differ (range: 120–16 months) because children began treatment at different times. During the treatment 4 patients recovered their parameters and the medication was suspended; 2 patients continued the treatment with favorable evolution. Two children evolved slowly with normal growth and development. One girl became diabetic because she was treated late. Conclusion: In children at risk, this treatment delays the development or remits the evolution of type 1 diabetes.Fil: Fernandez, Ivana Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Passicot, Gisel Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Martucci, Lucia Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFreund Publishing House Ltd2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/275046Fernandez, Ivana Cristina; Camberos, Maria del Carmen; Passicot, Gisel Anabel; Martucci, Lucia Camila; Cresto, Juan Carlos; Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 26; 3-4; 6-2012; 347-3550334-018XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyterbrill.com/document/doi/10.1515/jpem-2012-0128/htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/jpem-2012-0128info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-03T10:00:31Zoai:ri.conicet.gov.ar:11336/275046instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-03 10:00:31.643CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
title Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
spellingShingle Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
Fernandez, Ivana Cristina
Acetyl-L- carnitine plus nicotinamide treatment
Patients at risk for type I diabetes
Longitudinal study
title_short Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
title_full Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
title_fullStr Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
title_full_unstemmed Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
title_sort Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports
dc.creator.none.fl_str_mv Fernandez, Ivana Cristina
Camberos, Maria del Carmen
Passicot, Gisel Anabel
Martucci, Lucia Camila
Cresto, Juan Carlos
author Fernandez, Ivana Cristina
author_facet Fernandez, Ivana Cristina
Camberos, Maria del Carmen
Passicot, Gisel Anabel
Martucci, Lucia Camila
Cresto, Juan Carlos
author_role author
author2 Camberos, Maria del Carmen
Passicot, Gisel Anabel
Martucci, Lucia Camila
Cresto, Juan Carlos
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acetyl-L- carnitine plus nicotinamide treatment
Patients at risk for type I diabetes
Longitudinal study
topic Acetyl-L- carnitine plus nicotinamide treatment
Patients at risk for type I diabetes
Longitudinal study
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Patients: Nine out of seventy healthy participants of the type 1 diabetes risk study were treated. They were typified for diabetes with HLA-DQB1 and positive autoantibodies. Children with a first peak of insulin response ≤ 48 μU were randomly distributed in control and treated patients. Children evolution was followed with an intravenous glucose tolerance test. Control children were treated when was another risk parameter was added. During their evolution all children were treated. Results: Treatment periods differ (range: 120–16 months) because children began treatment at different times. During the treatment 4 patients recovered their parameters and the medication was suspended; 2 patients continued the treatment with favorable evolution. Two children evolved slowly with normal growth and development. One girl became diabetic because she was treated late. Conclusion: In children at risk, this treatment delays the development or remits the evolution of type 1 diabetes.
Fil: Fernandez, Ivana Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Passicot, Gisel Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Martucci, Lucia Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
description Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Patients: Nine out of seventy healthy participants of the type 1 diabetes risk study were treated. They were typified for diabetes with HLA-DQB1 and positive autoantibodies. Children with a first peak of insulin response ≤ 48 μU were randomly distributed in control and treated patients. Children evolution was followed with an intravenous glucose tolerance test. Control children were treated when was another risk parameter was added. During their evolution all children were treated. Results: Treatment periods differ (range: 120–16 months) because children began treatment at different times. During the treatment 4 patients recovered their parameters and the medication was suspended; 2 patients continued the treatment with favorable evolution. Two children evolved slowly with normal growth and development. One girl became diabetic because she was treated late. Conclusion: In children at risk, this treatment delays the development or remits the evolution of type 1 diabetes.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/275046
Fernandez, Ivana Cristina; Camberos, Maria del Carmen; Passicot, Gisel Anabel; Martucci, Lucia Camila; Cresto, Juan Carlos; Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 26; 3-4; 6-2012; 347-355
0334-018X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/275046
identifier_str_mv Fernandez, Ivana Cristina; Camberos, Maria del Carmen; Passicot, Gisel Anabel; Martucci, Lucia Camila; Cresto, Juan Carlos; Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 26; 3-4; 6-2012; 347-355
0334-018X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyterbrill.com/document/doi/10.1515/jpem-2012-0128/html
info:eu-repo/semantics/altIdentifier/doi/10.1515/jpem-2012-0128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Freund Publishing House Ltd
publisher.none.fl_str_mv Freund Publishing House Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.275514

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