Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment
- Autores
- Fernandez, Ivana; Tonietti, Miriam; Camberos, Maria del Carmen; Bergada, Ignacio; Schenone, Andrea; Szlago, Marina; Tellechea, Mariana Lorena; Fretchtel, Gustavo; Trifone, Liliana; Cresto, Juan Carlos
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- n the first part, this article review the accepted knowledge of type 1 diabetes, its physiopathology, the importance of cytokines and the induction of apoptosis and necrosis during its evolution. Throughout this work we describe in more detail the inhibition of this mechanism of cell destruction by acetyl-L-carnitine and nicotinamide. We also explain the complementary action of their association which gave support to the treatment. In the second part, we present the complete evolution of 8 children treated with the oral medication of 50 mg/Kg of acetyl-L-carnitine plus 25 mg/Kg of nicotinamide during 5 years. We published the first 2 years of evolution under treatment in these children (JPEM 26: 347, 2013). The children had positive auto-antibodies and were consanguineous of type 1 diabetic patients. The intravenous glucose tolerance test (IVGTT) showed a first phase of insulin release minor of 48 μU to enter in the protocol, and the same test was used for children evolution. Seven out eight children stopped the treatment because they normalized the metabolic parameters and no one became diabetic. All children increased the insulin response to IVGTT (between 1.44 to 5.69 times). Along the treatment, seven of these eight children turned their positive auto-antibodies into negatives.
Fil: Fernandez, Ivana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Tonietti, Miriam. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Bergada, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Schenone, Andrea. Fundación de las Enfermedades Neurometabólicas; Argentina
Fil: Szlago, Marina. Fundación de las Enfermedades Neurometabólicas; Argentina
Fil: Tellechea, Mariana Lorena. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fretchtel, Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Trifone, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina - Materia
-
Acetyl-L-Carnitine and Nicotinamide treatment
Prevention of type 1 Diabetes
Evaluation of treatment - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/8185
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Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years TreatmentFernandez, IvanaTonietti, MiriamCamberos, Maria del CarmenBergada, IgnacioSchenone, AndreaSzlago, MarinaTellechea, Mariana LorenaFretchtel, GustavoTrifone, LilianaCresto, Juan CarlosAcetyl-L-Carnitine and Nicotinamide treatmentPrevention of type 1 DiabetesEvaluation of treatmenthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3n the first part, this article review the accepted knowledge of type 1 diabetes, its physiopathology, the importance of cytokines and the induction of apoptosis and necrosis during its evolution. Throughout this work we describe in more detail the inhibition of this mechanism of cell destruction by acetyl-L-carnitine and nicotinamide. We also explain the complementary action of their association which gave support to the treatment. In the second part, we present the complete evolution of 8 children treated with the oral medication of 50 mg/Kg of acetyl-L-carnitine plus 25 mg/Kg of nicotinamide during 5 years. We published the first 2 years of evolution under treatment in these children (JPEM 26: 347, 2013). The children had positive auto-antibodies and were consanguineous of type 1 diabetic patients. The intravenous glucose tolerance test (IVGTT) showed a first phase of insulin release minor of 48 μU to enter in the protocol, and the same test was used for children evolution. Seven out eight children stopped the treatment because they normalized the metabolic parameters and no one became diabetic. All children increased the insulin response to IVGTT (between 1.44 to 5.69 times). Along the treatment, seven of these eight children turned their positive auto-antibodies into negatives.Fil: Fernandez, Ivana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; ArgentinaFil: Tonietti, Miriam. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; ArgentinaFil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Bergada, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Schenone, Andrea. Fundación de las Enfermedades Neurometabólicas; ArgentinaFil: Szlago, Marina. Fundación de las Enfermedades Neurometabólicas; ArgentinaFil: Tellechea, Mariana Lorena. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Fretchtel, Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Trifone, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; ArgentinaFil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaOmics International2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8185Fernandez, Ivana; Tonietti, Miriam; Camberos, Maria del Carmen; Bergada, Ignacio; Schenone, Andrea; et al.; Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment; Omics International; Immunome Research; 11; 2; 6-2015; 1000094-10000941745-7580enginfo:eu-repo/semantics/altIdentifier/url/http://www.omicsonline.com/open-access/acetyllcarnitine-and-nicotinamide-for-prevention-of-type-1-diabetes-iliterature-review-which-gave-support-to-the-treatment-iicase-report-evaluation-of-five-years-treatment-1745-7580-1000094.php?aid=55708info:eu-repo/semantics/altIdentifier/doi/10.4172/17457580.1000094info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:28Zoai:ri.conicet.gov.ar:11336/8185instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:28.999CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
title |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
spellingShingle |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment Fernandez, Ivana Acetyl-L-Carnitine and Nicotinamide treatment Prevention of type 1 Diabetes Evaluation of treatment |
title_short |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
title_full |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
title_fullStr |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
title_full_unstemmed |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
title_sort |
Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment |
dc.creator.none.fl_str_mv |
Fernandez, Ivana Tonietti, Miriam Camberos, Maria del Carmen Bergada, Ignacio Schenone, Andrea Szlago, Marina Tellechea, Mariana Lorena Fretchtel, Gustavo Trifone, Liliana Cresto, Juan Carlos |
author |
Fernandez, Ivana |
author_facet |
Fernandez, Ivana Tonietti, Miriam Camberos, Maria del Carmen Bergada, Ignacio Schenone, Andrea Szlago, Marina Tellechea, Mariana Lorena Fretchtel, Gustavo Trifone, Liliana Cresto, Juan Carlos |
author_role |
author |
author2 |
Tonietti, Miriam Camberos, Maria del Carmen Bergada, Ignacio Schenone, Andrea Szlago, Marina Tellechea, Mariana Lorena Fretchtel, Gustavo Trifone, Liliana Cresto, Juan Carlos |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Acetyl-L-Carnitine and Nicotinamide treatment Prevention of type 1 Diabetes Evaluation of treatment |
topic |
Acetyl-L-Carnitine and Nicotinamide treatment Prevention of type 1 Diabetes Evaluation of treatment |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
n the first part, this article review the accepted knowledge of type 1 diabetes, its physiopathology, the importance of cytokines and the induction of apoptosis and necrosis during its evolution. Throughout this work we describe in more detail the inhibition of this mechanism of cell destruction by acetyl-L-carnitine and nicotinamide. We also explain the complementary action of their association which gave support to the treatment. In the second part, we present the complete evolution of 8 children treated with the oral medication of 50 mg/Kg of acetyl-L-carnitine plus 25 mg/Kg of nicotinamide during 5 years. We published the first 2 years of evolution under treatment in these children (JPEM 26: 347, 2013). The children had positive auto-antibodies and were consanguineous of type 1 diabetic patients. The intravenous glucose tolerance test (IVGTT) showed a first phase of insulin release minor of 48 μU to enter in the protocol, and the same test was used for children evolution. Seven out eight children stopped the treatment because they normalized the metabolic parameters and no one became diabetic. All children increased the insulin response to IVGTT (between 1.44 to 5.69 times). Along the treatment, seven of these eight children turned their positive auto-antibodies into negatives. Fil: Fernandez, Ivana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina Fil: Tonietti, Miriam. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina Fil: Camberos, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina Fil: Bergada, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina Fil: Schenone, Andrea. Fundación de las Enfermedades Neurometabólicas; Argentina Fil: Szlago, Marina. Fundación de las Enfermedades Neurometabólicas; Argentina Fil: Tellechea, Mariana Lorena. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Fretchtel, Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Trifone, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina Fil: Cresto, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina |
description |
n the first part, this article review the accepted knowledge of type 1 diabetes, its physiopathology, the importance of cytokines and the induction of apoptosis and necrosis during its evolution. Throughout this work we describe in more detail the inhibition of this mechanism of cell destruction by acetyl-L-carnitine and nicotinamide. We also explain the complementary action of their association which gave support to the treatment. In the second part, we present the complete evolution of 8 children treated with the oral medication of 50 mg/Kg of acetyl-L-carnitine plus 25 mg/Kg of nicotinamide during 5 years. We published the first 2 years of evolution under treatment in these children (JPEM 26: 347, 2013). The children had positive auto-antibodies and were consanguineous of type 1 diabetic patients. The intravenous glucose tolerance test (IVGTT) showed a first phase of insulin release minor of 48 μU to enter in the protocol, and the same test was used for children evolution. Seven out eight children stopped the treatment because they normalized the metabolic parameters and no one became diabetic. All children increased the insulin response to IVGTT (between 1.44 to 5.69 times). Along the treatment, seven of these eight children turned their positive auto-antibodies into negatives. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/8185 Fernandez, Ivana; Tonietti, Miriam; Camberos, Maria del Carmen; Bergada, Ignacio; Schenone, Andrea; et al.; Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment; Omics International; Immunome Research; 11; 2; 6-2015; 1000094-1000094 1745-7580 |
url |
http://hdl.handle.net/11336/8185 |
identifier_str_mv |
Fernandez, Ivana; Tonietti, Miriam; Camberos, Maria del Carmen; Bergada, Ignacio; Schenone, Andrea; et al.; Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1Diabetes I-Literature Rewiew Which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment; Omics International; Immunome Research; 11; 2; 6-2015; 1000094-1000094 1745-7580 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.omicsonline.com/open-access/acetyllcarnitine-and-nicotinamide-for-prevention-of-type-1-diabetes-iliterature-review-which-gave-support-to-the-treatment-iicase-report-evaluation-of-five-years-treatment-1745-7580-1000094.php?aid=55708 info:eu-repo/semantics/altIdentifier/doi/10.4172/17457580.1000094 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Omics International |
publisher.none.fl_str_mv |
Omics International |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613809022435328 |
score |
13.070432 |