The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Autores
Biancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; Macdonald, Thomas T.; Corazza, Gino Roberto; Di Sabatino, Antonio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transforming growth factor (TGF)-b, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-balso enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-b signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-b signaling in chronic intestinal diseases.
Fil: Biancheri, Paolo. University of Pavia; Italia. Barts and The London School of Medicine and Dentistry; Reino Unido
Fil: Giuffrida, Paolo. University of Pavia; Italia
Fil: Docena, Guillermo H.. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
Fil: Macdonald, Thomas T.. Barts and The London School of Medicine and Dentistry; Reino Unido
Fil: Corazza, Gino Roberto. University of Pavia; Italia
Fil: Di Sabatino, Antonio. University of Pavia; Italia
Materia
Celiac Disease
Crohn´S Disease
Myofibroblast
Rregulatory T Cell
Smad
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10225
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/10225
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gutBiancheri, PaoloGiuffrida, PaoloDocena, Guillermo H.Macdonald, Thomas T.Corazza, Gino RobertoDi Sabatino, AntonioCeliac DiseaseCrohn´S DiseaseMyofibroblastRregulatory T CellSmadhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Transforming growth factor (TGF)-b, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-balso enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-b signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-b signaling in chronic intestinal diseases.Fil: Biancheri, Paolo. University of Pavia; Italia. Barts and The London School of Medicine and Dentistry; Reino UnidoFil: Giuffrida, Paolo. University of Pavia; ItaliaFil: Docena, Guillermo H.. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); ArgentinaFil: Macdonald, Thomas T.. Barts and The London School of Medicine and Dentistry; Reino UnidoFil: Corazza, Gino Roberto. University of Pavia; ItaliaFil: Di Sabatino, Antonio. University of Pavia; ItaliaElsevier2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10225Biancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; Macdonald, Thomas T.; Corazza, Gino Roberto; et al.; The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut; Elsevier; Cytokine & Growth Factor Reviews; 25; 1; 2-2014; 45-551359-6101enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2013.11.001info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24332927info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:39:01Zoai:ri.conicet.gov.ar:11336/10225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:39:01.286CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
title The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
spellingShingle The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
Biancheri, Paolo
Celiac Disease
Crohn´S Disease
Myofibroblast
Rregulatory T Cell
Smad
title_short The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
title_full The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
title_fullStr The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
title_full_unstemmed The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
title_sort The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut
dc.creator.none.fl_str_mv Biancheri, Paolo
Giuffrida, Paolo
Docena, Guillermo H.
Macdonald, Thomas T.
Corazza, Gino Roberto
Di Sabatino, Antonio
author Biancheri, Paolo
author_facet Biancheri, Paolo
Giuffrida, Paolo
Docena, Guillermo H.
Macdonald, Thomas T.
Corazza, Gino Roberto
Di Sabatino, Antonio
author_role author
author2 Giuffrida, Paolo
Docena, Guillermo H.
Macdonald, Thomas T.
Corazza, Gino Roberto
Di Sabatino, Antonio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Celiac Disease
Crohn´S Disease
Myofibroblast
Rregulatory T Cell
Smad
topic Celiac Disease
Crohn´S Disease
Myofibroblast
Rregulatory T Cell
Smad
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Transforming growth factor (TGF)-b, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-balso enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-b signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-b signaling in chronic intestinal diseases.
Fil: Biancheri, Paolo. University of Pavia; Italia. Barts and The London School of Medicine and Dentistry; Reino Unido
Fil: Giuffrida, Paolo. University of Pavia; Italia
Fil: Docena, Guillermo H.. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
Fil: Macdonald, Thomas T.. Barts and The London School of Medicine and Dentistry; Reino Unido
Fil: Corazza, Gino Roberto. University of Pavia; Italia
Fil: Di Sabatino, Antonio. University of Pavia; Italia
description Transforming growth factor (TGF)-b, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-balso enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-b signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-b signaling in chronic intestinal diseases.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10225
Biancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; Macdonald, Thomas T.; Corazza, Gino Roberto; et al.; The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut; Elsevier; Cytokine & Growth Factor Reviews; 25; 1; 2-2014; 45-55
1359-6101
url http://hdl.handle.net/11336/10225
identifier_str_mv Biancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; Macdonald, Thomas T.; Corazza, Gino Roberto; et al.; The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut; Elsevier; Cytokine & Growth Factor Reviews; 25; 1; 2-2014; 45-55
1359-6101
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2013.11.001
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24332927
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082872707907584
score 13.22299

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