Regulation of alternative splicing through coupling with transcription and chromatin structure

Autores
Naftelberg, Shiran; Schor, Ignacio Esteban; Ast, Gil; Kornblihtt, Alberto Rodolfo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.
Fil: Naftelberg S. Sackler Medical School - Tel Aviv University; Israel
Fil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Ast, Gil. Sackler Medical School, Tel Aviv; Israel
Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
ALTERNATIVE SPLICING
CHROMATIN ORGANIZATION
HISTONE MODIFICATIONS
MOLECULAR EVOLUTION
NUCLEOSOME POSITIONING
TRANSCRIPTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93849
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of alternative splicing through coupling with transcription and chromatin structureNaftelberg, ShiranSchor, Ignacio EstebanAst, GilKornblihtt, Alberto RodolfoALTERNATIVE SPLICINGCHROMATIN ORGANIZATIONHISTONE MODIFICATIONSMOLECULAR EVOLUTIONNUCLEOSOME POSITIONINGTRANSCRIPTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.Fil: Naftelberg S. Sackler Medical School - Tel Aviv University; IsraelFil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Ast, Gil. Sackler Medical School, Tel Aviv; IsraelFil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaAnnual Reviews2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93849Naftelberg, Shiran; Schor, Ignacio Esteban; Ast, Gil; Kornblihtt, Alberto Rodolfo; Regulation of alternative splicing through coupling with transcription and chromatin structure; Annual Reviews; Annual Review Of Biochemistry; 84; 6-2015; 165-1980066-4154CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-060614-034242info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-biochem-060614-034242info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:29:34Zoai:ri.conicet.gov.ar:11336/93849instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:29:34.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of alternative splicing through coupling with transcription and chromatin structure
title Regulation of alternative splicing through coupling with transcription and chromatin structure
spellingShingle Regulation of alternative splicing through coupling with transcription and chromatin structure
Naftelberg, Shiran
ALTERNATIVE SPLICING
CHROMATIN ORGANIZATION
HISTONE MODIFICATIONS
MOLECULAR EVOLUTION
NUCLEOSOME POSITIONING
TRANSCRIPTION
title_short Regulation of alternative splicing through coupling with transcription and chromatin structure
title_full Regulation of alternative splicing through coupling with transcription and chromatin structure
title_fullStr Regulation of alternative splicing through coupling with transcription and chromatin structure
title_full_unstemmed Regulation of alternative splicing through coupling with transcription and chromatin structure
title_sort Regulation of alternative splicing through coupling with transcription and chromatin structure
dc.creator.none.fl_str_mv Naftelberg, Shiran
Schor, Ignacio Esteban
Ast, Gil
Kornblihtt, Alberto Rodolfo
author Naftelberg, Shiran
author_facet Naftelberg, Shiran
Schor, Ignacio Esteban
Ast, Gil
Kornblihtt, Alberto Rodolfo
author_role author
author2 Schor, Ignacio Esteban
Ast, Gil
Kornblihtt, Alberto Rodolfo
author2_role author
author
author
dc.subject.none.fl_str_mv ALTERNATIVE SPLICING
CHROMATIN ORGANIZATION
HISTONE MODIFICATIONS
MOLECULAR EVOLUTION
NUCLEOSOME POSITIONING
TRANSCRIPTION
topic ALTERNATIVE SPLICING
CHROMATIN ORGANIZATION
HISTONE MODIFICATIONS
MOLECULAR EVOLUTION
NUCLEOSOME POSITIONING
TRANSCRIPTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.
Fil: Naftelberg S. Sackler Medical School - Tel Aviv University; Israel
Fil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Ast, Gil. Sackler Medical School, Tel Aviv; Israel
Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93849
Naftelberg, Shiran; Schor, Ignacio Esteban; Ast, Gil; Kornblihtt, Alberto Rodolfo; Regulation of alternative splicing through coupling with transcription and chromatin structure; Annual Reviews; Annual Review Of Biochemistry; 84; 6-2015; 165-198
0066-4154
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93849
identifier_str_mv Naftelberg, Shiran; Schor, Ignacio Esteban; Ast, Gil; Kornblihtt, Alberto Rodolfo; Regulation of alternative splicing through coupling with transcription and chromatin structure; Annual Reviews; Annual Review Of Biochemistry; 84; 6-2015; 165-198
0066-4154
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-060614-034242
info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-biochem-060614-034242
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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