Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine

Autores
Varani, Andrés P.; Aso, Ester; Maldonado, Rafael; Balerio, Graciela Noemí
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3 mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3 mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1 mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3 mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1 mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.
Fil: Varani, Andrés P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Aso, Ester. Universitat Pompeu Fabra; España
Fil: Maldonado, Rafael. Universitat Pompeu Fabra; España
Fil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
Materia
Nicotin
Baclofen
2-Hydroxysaclofen
Gaba B Receptors
Nociception
Locomotion
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13587
Acceder
id CONICETDig_78d00173e839e094b1827fea716ef257
oai_identifier_str oai:ri.conicet.gov.ar:11336/13587
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotineVarani, Andrés P.Aso, EsterMaldonado, RafaelBalerio, Graciela NoemíNicotinBaclofen2-HydroxysaclofenGaba B ReceptorsNociceptionLocomotionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3 mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3 mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1 mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3 mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1 mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.Fil: Varani, Andrés P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Aso, Ester. Universitat Pompeu Fabra; EspañaFil: Maldonado, Rafael. Universitat Pompeu Fabra; EspañaFil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; ArgentinaElsevier Science2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13587Varani, Andrés P.; Aso, Ester; Maldonado, Rafael; Balerio, Graciela Noemí; Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine; Elsevier Science; European Journal Of Pharmacology; 738; 9-2014; 200-2050014-2999enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014299914004014info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2014.05.039info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:30:09Zoai:ri.conicet.gov.ar:11336/13587instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:30:10.088CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
title Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
spellingShingle Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
Varani, Andrés P.
Nicotin
Baclofen
2-Hydroxysaclofen
Gaba B Receptors
Nociception
Locomotion
title_short Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
title_full Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
title_fullStr Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
title_full_unstemmed Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
title_sort Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
dc.creator.none.fl_str_mv Varani, Andrés P.
Aso, Ester
Maldonado, Rafael
Balerio, Graciela Noemí
author Varani, Andrés P.
author_facet Varani, Andrés P.
Aso, Ester
Maldonado, Rafael
Balerio, Graciela Noemí
author_role author
author2 Aso, Ester
Maldonado, Rafael
Balerio, Graciela Noemí
author2_role author
author
author
dc.subject.none.fl_str_mv Nicotin
Baclofen
2-Hydroxysaclofen
Gaba B Receptors
Nociception
Locomotion
topic Nicotin
Baclofen
2-Hydroxysaclofen
Gaba B Receptors
Nociception
Locomotion
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3 mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3 mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1 mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3 mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1 mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.
Fil: Varani, Andrés P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Aso, Ester. Universitat Pompeu Fabra; España
Fil: Maldonado, Rafael. Universitat Pompeu Fabra; España
Fil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
description The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3 mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3 mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1 mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3 mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1 mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13587
Varani, Andrés P.; Aso, Ester; Maldonado, Rafael; Balerio, Graciela Noemí; Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine; Elsevier Science; European Journal Of Pharmacology; 738; 9-2014; 200-205
0014-2999
url http://hdl.handle.net/11336/13587
identifier_str_mv Varani, Andrés P.; Aso, Ester; Maldonado, Rafael; Balerio, Graciela Noemí; Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine; Elsevier Science; European Journal Of Pharmacology; 738; 9-2014; 200-205
0014-2999
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014299914004014
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2014.05.039
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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