GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice

Autores
Varani, Andrés Pablo; Balerio, Graciela Noemí
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to evaluate the possible involvement of GABAB receptors in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Animals were exposed to nicotine only once. The acute administration of low (0.05 mg/kg, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus maze test; respectively, anxiolytic- and anxiogenic-like responses. The effect of pretreatment with either the GABAB receptor antagonist 2-OH-saclofen (0.25, 0.5 and 1 mg/kg; ip) or the GABAB receptor agonist baclofen (0.5, 1 and 2 mg/kg; ip), was evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. 2-OH-saclofen completely abolished both nicotine-induced effects (p < 0.001) at the highest dose tested, suggesting an involvement of GABAB receptors in these behavioural responses. On the other hand, baclofen failed to modify the anxiety-related effects of nicotine. These results suggest that the GABAB receptors are involved in the regulation of nicotine-induced anxiety-related behavioural responses in mice, and provide new findings to support a potential pharmaco therapeutic use of GABAergic drugs in the treatment of tobacco addiction.
Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Materia
Nicotine
Baclofen
2-OH-saclofen
Anxiety
GABAB receptors
Mice
Anxiety
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272437
Acceder
id CONICETDig_ef08313851fac73fe0d0dccc2a398bf2
oai_identifier_str oai:ri.conicet.gov.ar:11336/272437
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in miceVarani, Andrés PabloBalerio, Graciela NoemíNicotineBaclofen2-OH-saclofenAnxietyGABAB receptorsMiceAnxietyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of the present study was to evaluate the possible involvement of GABAB receptors in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Animals were exposed to nicotine only once. The acute administration of low (0.05 mg/kg, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus maze test; respectively, anxiolytic- and anxiogenic-like responses. The effect of pretreatment with either the GABAB receptor antagonist 2-OH-saclofen (0.25, 0.5 and 1 mg/kg; ip) or the GABAB receptor agonist baclofen (0.5, 1 and 2 mg/kg; ip), was evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. 2-OH-saclofen completely abolished both nicotine-induced effects (p < 0.001) at the highest dose tested, suggesting an involvement of GABAB receptors in these behavioural responses. On the other hand, baclofen failed to modify the anxiety-related effects of nicotine. These results suggest that the GABAB receptors are involved in the regulation of nicotine-induced anxiety-related behavioural responses in mice, and provide new findings to support a potential pharmaco therapeutic use of GABAergic drugs in the treatment of tobacco addiction.Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272437Varani, Andrés Pablo; Balerio, Graciela Noemí; GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 65; 5; 5-2012; 507-5131043-6618CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661812000412info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2012.03.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:04Zoai:ri.conicet.gov.ar:11336/272437instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:04.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
title GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
spellingShingle GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
Varani, Andrés Pablo
Nicotine
Baclofen
2-OH-saclofen
Anxiety
GABAB receptors
Mice
Anxiety
title_short GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
title_full GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
title_fullStr GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
title_full_unstemmed GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
title_sort GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice
dc.creator.none.fl_str_mv Varani, Andrés Pablo
Balerio, Graciela Noemí
author Varani, Andrés Pablo
author_facet Varani, Andrés Pablo
Balerio, Graciela Noemí
author_role author
author2 Balerio, Graciela Noemí
author2_role author
dc.subject.none.fl_str_mv Nicotine
Baclofen
2-OH-saclofen
Anxiety
GABAB receptors
Mice
Anxiety
topic Nicotine
Baclofen
2-OH-saclofen
Anxiety
GABAB receptors
Mice
Anxiety
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present study was to evaluate the possible involvement of GABAB receptors in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Animals were exposed to nicotine only once. The acute administration of low (0.05 mg/kg, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus maze test; respectively, anxiolytic- and anxiogenic-like responses. The effect of pretreatment with either the GABAB receptor antagonist 2-OH-saclofen (0.25, 0.5 and 1 mg/kg; ip) or the GABAB receptor agonist baclofen (0.5, 1 and 2 mg/kg; ip), was evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. 2-OH-saclofen completely abolished both nicotine-induced effects (p < 0.001) at the highest dose tested, suggesting an involvement of GABAB receptors in these behavioural responses. On the other hand, baclofen failed to modify the anxiety-related effects of nicotine. These results suggest that the GABAB receptors are involved in the regulation of nicotine-induced anxiety-related behavioural responses in mice, and provide new findings to support a potential pharmaco therapeutic use of GABAergic drugs in the treatment of tobacco addiction.
Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
description The aim of the present study was to evaluate the possible involvement of GABAB receptors in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Animals were exposed to nicotine only once. The acute administration of low (0.05 mg/kg, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus maze test; respectively, anxiolytic- and anxiogenic-like responses. The effect of pretreatment with either the GABAB receptor antagonist 2-OH-saclofen (0.25, 0.5 and 1 mg/kg; ip) or the GABAB receptor agonist baclofen (0.5, 1 and 2 mg/kg; ip), was evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. 2-OH-saclofen completely abolished both nicotine-induced effects (p < 0.001) at the highest dose tested, suggesting an involvement of GABAB receptors in these behavioural responses. On the other hand, baclofen failed to modify the anxiety-related effects of nicotine. These results suggest that the GABAB receptors are involved in the regulation of nicotine-induced anxiety-related behavioural responses in mice, and provide new findings to support a potential pharmaco therapeutic use of GABAergic drugs in the treatment of tobacco addiction.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272437
Varani, Andrés Pablo; Balerio, Graciela Noemí; GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 65; 5; 5-2012; 507-513
1043-6618
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272437
identifier_str_mv Varani, Andrés Pablo; Balerio, Graciela Noemí; GABAB receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 65; 5; 5-2012; 507-513
1043-6618
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1043661812000412
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2012.03.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082635150917632
score 13.22299

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