Neanderthal introgression in SCN9A impacts mechanical pain sensitivity
- Autores
- Faux, Pierre; Ding, Li; Ramirez Aristeguieta, Luis Miguel; Chacón Duque, J. Camilo; Comini, Maddalena; Mendoza Revilla, Javier; Fuentes Guajardo, Macarena; Jaramillo, Claudia; Arias, William; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Barquera, Rodrigo; Everardo Martínez, Paola; Quinto Sánchez, Mirsha Emmanuel; Gómez Valdés, Jorge; Villamil Ramírez, Hugo; Silva de Cerqueira, Caio Cesar; Hünemeier, Tábita; Ramallo, Virginia; Gonzalez-Jose, Rolando; Schüler-Faccini, Lavinia; Bortolini, María Cátira; Acuña Alonzo, Victor; Canizales Quinteros, Samuel; Poletti, Giovanni; Gallo, Carla; Rothhammer, Francisco; Rojas, Winston; Schmid, Annina B.; Adhikari, Kaustubh; Bennett, David L.; Ruiz Linares, Andrés
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of ~123 kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function.
Fil: Faux, Pierre. Centre National de la Recherche Scientifique; Francia. Université de Toulouse; Francia. Fudan University; China. Aix-Marseille Université; Francia
Fil: Ding, Li. Fudan University; China
Fil: Ramirez Aristeguieta, Luis Miguel. Universidad de Antioquia; Colombia
Fil: Chacón Duque, J. Camilo. Stockholms Universitet; Suecia. University College London; Estados Unidos
Fil: Comini, Maddalena. University of Oxford; Reino Unido
Fil: Mendoza Revilla, Javier. Universidad Peruana Cayetano Heredia; Perú. Instituto Pasteur; Francia
Fil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; Chile
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú
Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú
Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú
Fil: Barquera, Rodrigo. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Max Planck Institute for the Science of Human History; Alemania
Fil: Everardo Martínez, Paola. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México
Fil: Quinto Sánchez, Mirsha Emmanuel. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Universidad Nacional Autónoma de México; México
Fil: Gómez Valdés, Jorge. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México
Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México
Fil: Silva de Cerqueira, Caio Cesar. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Rojas, Winston. Universidad de Antioquia; Colombia
Fil: Schmid, Annina B.. University of Oxford; Reino Unido
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino Unido
Fil: Bennett, David L.. University of Oxford; Reino Unido
Fil: Ruiz Linares, Andrés. University College London; Estados Unidos. Aix-Marseille Université; Francia. Fudan University; China - Materia
-
NEANDERTAL
LATINAMERICANS
ADMIXTURE
GENOMICS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/217033
Ver los metadatos del registro completo
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Neanderthal introgression in SCN9A impacts mechanical pain sensitivityFaux, PierreDing, LiRamirez Aristeguieta, Luis MiguelChacón Duque, J. CamiloComini, MaddalenaMendoza Revilla, JavierFuentes Guajardo, MacarenaJaramillo, ClaudiaArias, WilliamHurtado, MalenaVillegas, ValeriaGranja, VanessaBarquera, RodrigoEverardo Martínez, PaolaQuinto Sánchez, Mirsha EmmanuelGómez Valdés, JorgeVillamil Ramírez, HugoSilva de Cerqueira, Caio CesarHünemeier, TábitaRamallo, VirginiaGonzalez-Jose, RolandoSchüler-Faccini, LaviniaBortolini, María CátiraAcuña Alonzo, VictorCanizales Quinteros, SamuelPoletti, GiovanniGallo, CarlaRothhammer, FranciscoRojas, WinstonSchmid, Annina B.Adhikari, KaustubhBennett, David L.Ruiz Linares, AndrésNEANDERTALLATINAMERICANSADMIXTUREGENOMICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of ~123 kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function.Fil: Faux, Pierre. Centre National de la Recherche Scientifique; Francia. Université de Toulouse; Francia. Fudan University; China. Aix-Marseille Université; FranciaFil: Ding, Li. Fudan University; ChinaFil: Ramirez Aristeguieta, Luis Miguel. Universidad de Antioquia; ColombiaFil: Chacón Duque, J. Camilo. Stockholms Universitet; Suecia. University College London; Estados UnidosFil: Comini, Maddalena. University of Oxford; Reino UnidoFil: Mendoza Revilla, Javier. Universidad Peruana Cayetano Heredia; Perú. Instituto Pasteur; FranciaFil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; ChileFil: Jaramillo, Claudia. Universidad de Antioquia; ColombiaFil: Arias, William. Universidad de Antioquia; ColombiaFil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; PerúFil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; PerúFil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; PerúFil: Barquera, Rodrigo. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Max Planck Institute for the Science of Human History; AlemaniaFil: Everardo Martínez, Paola. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; MéxicoFil: Quinto Sánchez, Mirsha Emmanuel. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Universidad Nacional Autónoma de México; MéxicoFil: Gómez Valdés, Jorge. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; MéxicoFil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; MéxicoFil: Silva de Cerqueira, Caio Cesar. Universidade Federal do Rio Grande do Sul; BrasilFil: Hünemeier, Tábita. Universidade de Sao Paulo; BrasilFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; BrasilFil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Acuña Alonzo, Victor. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; MéxicoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Rojas, Winston. Universidad de Antioquia; ColombiaFil: Schmid, Annina B.. University of Oxford; Reino UnidoFil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino UnidoFil: Bennett, David L.. University of Oxford; Reino UnidoFil: Ruiz Linares, Andrés. University College London; Estados Unidos. Aix-Marseille Université; Francia. Fudan University; ChinaNature2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217033Faux, Pierre; Ding, Li; Ramirez Aristeguieta, Luis Miguel; Chacón Duque, J. Camilo; Comini, Maddalena; et al.; Neanderthal introgression in SCN9A impacts mechanical pain sensitivity; Nature; Communications Biology; 6; 1; 12-2023; 1-122399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-023-05286-zinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-023-05286-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:16Zoai:ri.conicet.gov.ar:11336/217033instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:16.745CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| title |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| spellingShingle |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity Faux, Pierre NEANDERTAL LATINAMERICANS ADMIXTURE GENOMICS |
| title_short |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| title_full |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| title_fullStr |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| title_full_unstemmed |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| title_sort |
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity |
| dc.creator.none.fl_str_mv |
Faux, Pierre Ding, Li Ramirez Aristeguieta, Luis Miguel Chacón Duque, J. Camilo Comini, Maddalena Mendoza Revilla, Javier Fuentes Guajardo, Macarena Jaramillo, Claudia Arias, William Hurtado, Malena Villegas, Valeria Granja, Vanessa Barquera, Rodrigo Everardo Martínez, Paola Quinto Sánchez, Mirsha Emmanuel Gómez Valdés, Jorge Villamil Ramírez, Hugo Silva de Cerqueira, Caio Cesar Hünemeier, Tábita Ramallo, Virginia Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Poletti, Giovanni Gallo, Carla Rothhammer, Francisco Rojas, Winston Schmid, Annina B. Adhikari, Kaustubh Bennett, David L. Ruiz Linares, Andrés |
| author |
Faux, Pierre |
| author_facet |
Faux, Pierre Ding, Li Ramirez Aristeguieta, Luis Miguel Chacón Duque, J. Camilo Comini, Maddalena Mendoza Revilla, Javier Fuentes Guajardo, Macarena Jaramillo, Claudia Arias, William Hurtado, Malena Villegas, Valeria Granja, Vanessa Barquera, Rodrigo Everardo Martínez, Paola Quinto Sánchez, Mirsha Emmanuel Gómez Valdés, Jorge Villamil Ramírez, Hugo Silva de Cerqueira, Caio Cesar Hünemeier, Tábita Ramallo, Virginia Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Poletti, Giovanni Gallo, Carla Rothhammer, Francisco Rojas, Winston Schmid, Annina B. Adhikari, Kaustubh Bennett, David L. Ruiz Linares, Andrés |
| author_role |
author |
| author2 |
Ding, Li Ramirez Aristeguieta, Luis Miguel Chacón Duque, J. Camilo Comini, Maddalena Mendoza Revilla, Javier Fuentes Guajardo, Macarena Jaramillo, Claudia Arias, William Hurtado, Malena Villegas, Valeria Granja, Vanessa Barquera, Rodrigo Everardo Martínez, Paola Quinto Sánchez, Mirsha Emmanuel Gómez Valdés, Jorge Villamil Ramírez, Hugo Silva de Cerqueira, Caio Cesar Hünemeier, Tábita Ramallo, Virginia Gonzalez-Jose, Rolando Schüler-Faccini, Lavinia Bortolini, María Cátira Acuña Alonzo, Victor Canizales Quinteros, Samuel Poletti, Giovanni Gallo, Carla Rothhammer, Francisco Rojas, Winston Schmid, Annina B. Adhikari, Kaustubh Bennett, David L. Ruiz Linares, Andrés |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
NEANDERTAL LATINAMERICANS ADMIXTURE GENOMICS |
| topic |
NEANDERTAL LATINAMERICANS ADMIXTURE GENOMICS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of ~123 kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function. Fil: Faux, Pierre. Centre National de la Recherche Scientifique; Francia. Université de Toulouse; Francia. Fudan University; China. Aix-Marseille Université; Francia Fil: Ding, Li. Fudan University; China Fil: Ramirez Aristeguieta, Luis Miguel. Universidad de Antioquia; Colombia Fil: Chacón Duque, J. Camilo. Stockholms Universitet; Suecia. University College London; Estados Unidos Fil: Comini, Maddalena. University of Oxford; Reino Unido Fil: Mendoza Revilla, Javier. Universidad Peruana Cayetano Heredia; Perú. Instituto Pasteur; Francia Fil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; Chile Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia Fil: Arias, William. Universidad de Antioquia; Colombia Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú Fil: Barquera, Rodrigo. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Max Planck Institute for the Science of Human History; Alemania Fil: Everardo Martínez, Paola. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México Fil: Quinto Sánchez, Mirsha Emmanuel. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México. Universidad Nacional Autónoma de México; México Fil: Gómez Valdés, Jorge. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México Fil: Silva de Cerqueira, Caio Cesar. Universidade Federal do Rio Grande do Sul; Brasil Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Schüler-Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropologia E Historia. Escuela Nacional de Antropología E Historia.; México Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Rojas, Winston. Universidad de Antioquia; Colombia Fil: Schmid, Annina B.. University of Oxford; Reino Unido Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido. The Open University (ou); Reino Unido Fil: Bennett, David L.. University of Oxford; Reino Unido Fil: Ruiz Linares, Andrés. University College London; Estados Unidos. Aix-Marseille Université; Francia. Fudan University; China |
| description |
The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of ~123 kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function. |
| publishDate |
2023 |
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2023-12 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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http://hdl.handle.net/11336/217033 Faux, Pierre; Ding, Li; Ramirez Aristeguieta, Luis Miguel; Chacón Duque, J. Camilo; Comini, Maddalena; et al.; Neanderthal introgression in SCN9A impacts mechanical pain sensitivity; Nature; Communications Biology; 6; 1; 12-2023; 1-12 2399-3642 CONICET Digital CONICET |
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http://hdl.handle.net/11336/217033 |
| identifier_str_mv |
Faux, Pierre; Ding, Li; Ramirez Aristeguieta, Luis Miguel; Chacón Duque, J. Camilo; Comini, Maddalena; et al.; Neanderthal introgression in SCN9A impacts mechanical pain sensitivity; Nature; Communications Biology; 6; 1; 12-2023; 1-12 2399-3642 CONICET Digital CONICET |
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eng |
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Nature |
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