Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant

Autores
Rodriguez, Ana María del Valle; Derita, Marcos Gabriel; Cartagena, Elena; Hernandez, Marcela Alicia; Bardon, Alicia del Valle
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chemical investigation of the fern Pityrogramma trifoliata (L.) R. M. Tryon (Pteridaceae) yielded a new complex flavonoid, here named trifoliatol, and 4 known complex flavonoids in addition to known chalcones and flavanones. The absolute configuration of the complex flavonoids is proposed, based on circular dichroism (ECD), crystal x-ray diffraction, and [α]D measurements. White and yellow farinas, as well as 10 flavonoids were tested for antifungal activity against a panel of clinically important fungi, including yeast and dermatophytes. Both farinas and 2 of the flavonoids were notably active against Trichophyton rubrum and T. mentagrophytes (MICs and MFCs between 7.8 and 31.2 μg/mL). The localization of flavonoids in the plant trichomes was accomplished by use of scanning electron microscopy and histochemical methods.
Fil: Rodriguez, Ana María del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Agropecuarias del Litoral. Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral; Argentina
Fil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
Fil: Hernandez, Marcela Alicia. Fundación Miguel Lillo; Argentina
Fil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ABSOLUTE CONFIGURATION
ANTIFUNGALS
COMPLEX FLAVONOIDS
FLAVONOIDS HISTOCHEMICAL LOCALIZATION
PITYROGRAMMA TRIFOLIATA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211083
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/211083
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the PlantRodriguez, Ana María del ValleDerita, Marcos GabrielCartagena, ElenaHernandez, Marcela AliciaBardon, Alicia del ValleABSOLUTE CONFIGURATIONANTIFUNGALSCOMPLEX FLAVONOIDSFLAVONOIDS HISTOCHEMICAL LOCALIZATIONPITYROGRAMMA TRIFOLIATAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chemical investigation of the fern Pityrogramma trifoliata (L.) R. M. Tryon (Pteridaceae) yielded a new complex flavonoid, here named trifoliatol, and 4 known complex flavonoids in addition to known chalcones and flavanones. The absolute configuration of the complex flavonoids is proposed, based on circular dichroism (ECD), crystal x-ray diffraction, and [α]D measurements. White and yellow farinas, as well as 10 flavonoids were tested for antifungal activity against a panel of clinically important fungi, including yeast and dermatophytes. Both farinas and 2 of the flavonoids were notably active against Trichophyton rubrum and T. mentagrophytes (MICs and MFCs between 7.8 and 31.2 μg/mL). The localization of flavonoids in the plant trichomes was accomplished by use of scanning electron microscopy and histochemical methods.Fil: Rodriguez, Ana María del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; ArgentinaFil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Agropecuarias del Litoral. Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral; ArgentinaFil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; ArgentinaFil: Hernandez, Marcela Alicia. Fundación Miguel Lillo; ArgentinaFil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSAGE Publications2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211083Rodriguez, Ana María del Valle; Derita, Marcos Gabriel; Cartagena, Elena; Hernandez, Marcela Alicia; Bardon, Alicia del Valle; Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant; SAGE Publications; Natural Product Communications; 17; 10; 10-2022; 1-101934-578XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1177/1934578X221114755info:eu-repo/semantics/altIdentifier/doi/10.1177/1934578X221114755info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:59Zoai:ri.conicet.gov.ar:11336/211083instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:59.812CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
title Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
spellingShingle Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
Rodriguez, Ana María del Valle
ABSOLUTE CONFIGURATION
ANTIFUNGALS
COMPLEX FLAVONOIDS
FLAVONOIDS HISTOCHEMICAL LOCALIZATION
PITYROGRAMMA TRIFOLIATA
title_short Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
title_full Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
title_fullStr Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
title_full_unstemmed Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
title_sort Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant
dc.creator.none.fl_str_mv Rodriguez, Ana María del Valle
Derita, Marcos Gabriel
Cartagena, Elena
Hernandez, Marcela Alicia
Bardon, Alicia del Valle
author Rodriguez, Ana María del Valle
author_facet Rodriguez, Ana María del Valle
Derita, Marcos Gabriel
Cartagena, Elena
Hernandez, Marcela Alicia
Bardon, Alicia del Valle
author_role author
author2 Derita, Marcos Gabriel
Cartagena, Elena
Hernandez, Marcela Alicia
Bardon, Alicia del Valle
author2_role author
author
author
author
dc.subject.none.fl_str_mv ABSOLUTE CONFIGURATION
ANTIFUNGALS
COMPLEX FLAVONOIDS
FLAVONOIDS HISTOCHEMICAL LOCALIZATION
PITYROGRAMMA TRIFOLIATA
topic ABSOLUTE CONFIGURATION
ANTIFUNGALS
COMPLEX FLAVONOIDS
FLAVONOIDS HISTOCHEMICAL LOCALIZATION
PITYROGRAMMA TRIFOLIATA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chemical investigation of the fern Pityrogramma trifoliata (L.) R. M. Tryon (Pteridaceae) yielded a new complex flavonoid, here named trifoliatol, and 4 known complex flavonoids in addition to known chalcones and flavanones. The absolute configuration of the complex flavonoids is proposed, based on circular dichroism (ECD), crystal x-ray diffraction, and [α]D measurements. White and yellow farinas, as well as 10 flavonoids were tested for antifungal activity against a panel of clinically important fungi, including yeast and dermatophytes. Both farinas and 2 of the flavonoids were notably active against Trichophyton rubrum and T. mentagrophytes (MICs and MFCs between 7.8 and 31.2 μg/mL). The localization of flavonoids in the plant trichomes was accomplished by use of scanning electron microscopy and histochemical methods.
Fil: Rodriguez, Ana María del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Agropecuarias del Litoral. Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral; Argentina
Fil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
Fil: Hernandez, Marcela Alicia. Fundación Miguel Lillo; Argentina
Fil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Chemical investigation of the fern Pityrogramma trifoliata (L.) R. M. Tryon (Pteridaceae) yielded a new complex flavonoid, here named trifoliatol, and 4 known complex flavonoids in addition to known chalcones and flavanones. The absolute configuration of the complex flavonoids is proposed, based on circular dichroism (ECD), crystal x-ray diffraction, and [α]D measurements. White and yellow farinas, as well as 10 flavonoids were tested for antifungal activity against a panel of clinically important fungi, including yeast and dermatophytes. Both farinas and 2 of the flavonoids were notably active against Trichophyton rubrum and T. mentagrophytes (MICs and MFCs between 7.8 and 31.2 μg/mL). The localization of flavonoids in the plant trichomes was accomplished by use of scanning electron microscopy and histochemical methods.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211083
Rodriguez, Ana María del Valle; Derita, Marcos Gabriel; Cartagena, Elena; Hernandez, Marcela Alicia; Bardon, Alicia del Valle; Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant; SAGE Publications; Natural Product Communications; 17; 10; 10-2022; 1-10
1934-578X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211083
identifier_str_mv Rodriguez, Ana María del Valle; Derita, Marcos Gabriel; Cartagena, Elena; Hernandez, Marcela Alicia; Bardon, Alicia del Valle; Complex Flavonoids of Pityrogramma trifoliata: Absolute Configuration, Antifungal Effects, and Localization in the Plant; SAGE Publications; Natural Product Communications; 17; 10; 10-2022; 1-10
1934-578X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1177/1934578X221114755
info:eu-repo/semantics/altIdentifier/doi/10.1177/1934578X221114755
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269985051770880
score 13.13397

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