Isolated flavonoids against mammary tumour cells LM2

Autores
Carli, Camila B. De A.; De Matos, Djamile C.; Lopes, Flávia C. M.; Maia, Danielle C. G.; Dias, Maristela B.; Sannomiya, Miriam; Rodrigues, Clenilson M.; Andreo, Marcio A.; Vilegas, Wagner; Colombo, Lucas Luis; Carlos, Iracilda Z.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities.
Fil: Carli, Camila B. De A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: De Matos, Djamile C.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Lopes, Flávia C. M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Maia, Danielle C. G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Dias, Maristela B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Sannomiya, Miriam. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Rodrigues, Clenilson M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Andreo, Marcio A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Vilegas, Wagner. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Carlos, Iracilda Z.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Materia
ANTITUMOUR ACTIVITY
CYTOKINE
FLAVONOIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117821
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/117821
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Isolated flavonoids against mammary tumour cells LM2Carli, Camila B. De A.De Matos, Djamile C.Lopes, Flávia C. M.Maia, Danielle C. G.Dias, Maristela B.Sannomiya, MiriamRodrigues, Clenilson M.Andreo, Marcio A.Vilegas, WagnerColombo, Lucas LuisCarlos, Iracilda Z.ANTITUMOUR ACTIVITYCYTOKINEFLAVONOIDShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities.Fil: Carli, Camila B. De A.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: De Matos, Djamile C.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Lopes, Flávia C. M.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maia, Danielle C. G.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Dias, Maristela B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Sannomiya, Miriam. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Rodrigues, Clenilson M.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Andreo, Marcio A.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Vilegas, Wagner. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Carlos, Iracilda Z.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilDe Gruyter2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117821Carli, Camila B. De A.; De Matos, Djamile C.; Lopes, Flávia C. M.; Maia, Danielle C. G.; Dias, Maristela B.; et al.; Isolated flavonoids against mammary tumour cells LM2; De Gruyter; Zeitschrift für Naturforschung C. A Journal of Biosciences; 64; 1-2; 1-2009; 32-360939-5075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/znc/64/1-2/article-p32.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/znc-2009-1-206info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:24Zoai:ri.conicet.gov.ar:11336/117821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:24.758CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Isolated flavonoids against mammary tumour cells LM2
title Isolated flavonoids against mammary tumour cells LM2
spellingShingle Isolated flavonoids against mammary tumour cells LM2
Carli, Camila B. De A.
ANTITUMOUR ACTIVITY
CYTOKINE
FLAVONOIDS
title_short Isolated flavonoids against mammary tumour cells LM2
title_full Isolated flavonoids against mammary tumour cells LM2
title_fullStr Isolated flavonoids against mammary tumour cells LM2
title_full_unstemmed Isolated flavonoids against mammary tumour cells LM2
title_sort Isolated flavonoids against mammary tumour cells LM2
dc.creator.none.fl_str_mv Carli, Camila B. De A.
De Matos, Djamile C.
Lopes, Flávia C. M.
Maia, Danielle C. G.
Dias, Maristela B.
Sannomiya, Miriam
Rodrigues, Clenilson M.
Andreo, Marcio A.
Vilegas, Wagner
Colombo, Lucas Luis
Carlos, Iracilda Z.
author Carli, Camila B. De A.
author_facet Carli, Camila B. De A.
De Matos, Djamile C.
Lopes, Flávia C. M.
Maia, Danielle C. G.
Dias, Maristela B.
Sannomiya, Miriam
Rodrigues, Clenilson M.
Andreo, Marcio A.
Vilegas, Wagner
Colombo, Lucas Luis
Carlos, Iracilda Z.
author_role author
author2 De Matos, Djamile C.
Lopes, Flávia C. M.
Maia, Danielle C. G.
Dias, Maristela B.
Sannomiya, Miriam
Rodrigues, Clenilson M.
Andreo, Marcio A.
Vilegas, Wagner
Colombo, Lucas Luis
Carlos, Iracilda Z.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTITUMOUR ACTIVITY
CYTOKINE
FLAVONOIDS
topic ANTITUMOUR ACTIVITY
CYTOKINE
FLAVONOIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities.
Fil: Carli, Camila B. De A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: De Matos, Djamile C.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Lopes, Flávia C. M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Maia, Danielle C. G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Dias, Maristela B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Sannomiya, Miriam. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Rodrigues, Clenilson M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Andreo, Marcio A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Vilegas, Wagner. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Carlos, Iracilda Z.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
description The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities.
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117821
Carli, Camila B. De A.; De Matos, Djamile C.; Lopes, Flávia C. M.; Maia, Danielle C. G.; Dias, Maristela B.; et al.; Isolated flavonoids against mammary tumour cells LM2; De Gruyter; Zeitschrift für Naturforschung C. A Journal of Biosciences; 64; 1-2; 1-2009; 32-36
0939-5075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117821
identifier_str_mv Carli, Camila B. De A.; De Matos, Djamile C.; Lopes, Flávia C. M.; Maia, Danielle C. G.; Dias, Maristela B.; et al.; Isolated flavonoids against mammary tumour cells LM2; De Gruyter; Zeitschrift für Naturforschung C. A Journal of Biosciences; 64; 1-2; 1-2009; 32-36
0939-5075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/znc/64/1-2/article-p32.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/znc-2009-1-206
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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