Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs

Autores
Campos, Adriana; Souza, Greice Maria Rodrigues; Monache, Franco Delle; Butassi, Estefanía; Zacchino, Susana Alicia Stella; Filho, Valdir Cechinel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 μg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.
Fil: Campos, Adriana. Universidade do Vale do Itajaí; Brasil
Fil: Souza, Greice Maria Rodrigues. Centro Universitário Euro-Americano; Brasil
Fil: Monache, Franco Delle. Universidade do Vale do Itajaí; Brasil
Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Filho, Valdir Cechinel. Universidade do Vale do Itajaí; Brasil
Materia
ANTIFUNGAL ACTIVITY
CIPURA PALUDOSA
PYRANONAPHTHOQUINONES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180223
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa BulbsCampos, AdrianaSouza, Greice Maria RodriguesMonache, Franco DelleButassi, EstefaníaZacchino, Susana Alicia StellaFilho, Valdir CechinelANTIFUNGAL ACTIVITYCIPURA PALUDOSAPYRANONAPHTHOQUINONEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 μg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.Fil: Campos, Adriana. Universidade do Vale do Itajaí; BrasilFil: Souza, Greice Maria Rodrigues. Centro Universitário Euro-Americano; BrasilFil: Monache, Franco Delle. Universidade do Vale do Itajaí; BrasilFil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Filho, Valdir Cechinel. Universidade do Vale do Itajaí; BrasilNatural Products2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180223Campos, Adriana; Souza, Greice Maria Rodrigues; Monache, Franco Delle; Butassi, Estefanía; Zacchino, Susana Alicia Stella; et al.; Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs; Natural Products; Natural Product Communications; 10; 9; 9-2015; 1589-15921934-578XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1501000926info:eu-repo/semantics/altIdentifier/doi/10.1177/1934578X1501000926info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:29Zoai:ri.conicet.gov.ar:11336/180223instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:29.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
title Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
spellingShingle Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
Campos, Adriana
ANTIFUNGAL ACTIVITY
CIPURA PALUDOSA
PYRANONAPHTHOQUINONES
title_short Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
title_full Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
title_fullStr Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
title_full_unstemmed Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
title_sort Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs
dc.creator.none.fl_str_mv Campos, Adriana
Souza, Greice Maria Rodrigues
Monache, Franco Delle
Butassi, Estefanía
Zacchino, Susana Alicia Stella
Filho, Valdir Cechinel
author Campos, Adriana
author_facet Campos, Adriana
Souza, Greice Maria Rodrigues
Monache, Franco Delle
Butassi, Estefanía
Zacchino, Susana Alicia Stella
Filho, Valdir Cechinel
author_role author
author2 Souza, Greice Maria Rodrigues
Monache, Franco Delle
Butassi, Estefanía
Zacchino, Susana Alicia Stella
Filho, Valdir Cechinel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL ACTIVITY
CIPURA PALUDOSA
PYRANONAPHTHOQUINONES
topic ANTIFUNGAL ACTIVITY
CIPURA PALUDOSA
PYRANONAPHTHOQUINONES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 μg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.
Fil: Campos, Adriana. Universidade do Vale do Itajaí; Brasil
Fil: Souza, Greice Maria Rodrigues. Centro Universitário Euro-Americano; Brasil
Fil: Monache, Franco Delle. Universidade do Vale do Itajaí; Brasil
Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Filho, Valdir Cechinel. Universidade do Vale do Itajaí; Brasil
description Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 μg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180223
Campos, Adriana; Souza, Greice Maria Rodrigues; Monache, Franco Delle; Butassi, Estefanía; Zacchino, Susana Alicia Stella; et al.; Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs; Natural Products; Natural Product Communications; 10; 9; 9-2015; 1589-1592
1934-578X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180223
identifier_str_mv Campos, Adriana; Souza, Greice Maria Rodrigues; Monache, Franco Delle; Butassi, Estefanía; Zacchino, Susana Alicia Stella; et al.; Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs; Natural Products; Natural Product Communications; 10; 9; 9-2015; 1589-1592
1934-578X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1501000926
info:eu-repo/semantics/altIdentifier/doi/10.1177/1934578X1501000926
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Natural Products
publisher.none.fl_str_mv Natural Products
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614147778543616
score 13.070432

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