Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry

Autores
Fries, Exequiel; Berli, Marcelo Eduardo; Campana, Diego Martin; Ubal, Sebastian; Di Paolo, José
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ventricular assist devices are a technological solution for patients who suffer from cardiac insufficiency and await a transplant. In this work, a new design of an implantable pulsatile blood pump is analyzed in terms of blood damage, by means of finite elements on a simplified geometry. It is a double effect volumetric pump, which has a noncontact driven piston and four active valves. The analysis is done by means of blood flow simulation into the pump and the prediction of platelets activation. The last is a measure of the pump compatibility with human life.The platelet activation state is evaluated by an equivalent or representative shear stress and compared with bibliographic data corresponding to other VAD kinds and cardiac prosthetic valves. The results show that, for the complementary blood flow rate supplied by the simulated VAD, the predicted platelet damage is in the same levels of current cardiac devices, particularly other VADs.
Fil: Fries, Exequiel. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Berli, Marcelo Eduardo. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Campana, Diego Martin. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Ubal, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Di Paolo, José. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Materia
Ventricular assist device
blood damage
platelet activation
pulsatile flow
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63446
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometryFries, ExequielBerli, Marcelo EduardoCampana, Diego MartinUbal, SebastianDi Paolo, JoséVentricular assist deviceblood damageplatelet activationpulsatile flowhttps://purl.org/becyt/ford/2.3https://purl.org/becyt/ford/2Ventricular assist devices are a technological solution for patients who suffer from cardiac insufficiency and await a transplant. In this work, a new design of an implantable pulsatile blood pump is analyzed in terms of blood damage, by means of finite elements on a simplified geometry. It is a double effect volumetric pump, which has a noncontact driven piston and four active valves. The analysis is done by means of blood flow simulation into the pump and the prediction of platelets activation. The last is a measure of the pump compatibility with human life.The platelet activation state is evaluated by an equivalent or representative shear stress and compared with bibliographic data corresponding to other VAD kinds and cardiac prosthetic valves. The results show that, for the complementary blood flow rate supplied by the simulated VAD, the predicted platelet damage is in the same levels of current cardiac devices, particularly other VADs.Fil: Fries, Exequiel. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; ArgentinaFil: Berli, Marcelo Eduardo. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; ArgentinaFil: Campana, Diego Martin. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; ArgentinaFil: Ubal, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Di Paolo, José. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; ArgentinaPlapiqui2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63446Fries, Exequiel; Berli, Marcelo Eduardo; Campana, Diego Martin; Ubal, Sebastian; Di Paolo, José; Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry; Plapiqui; Latin American Applied Research; 47; 3; 3-2017; 83-880327-07931851-8796CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.laar.uns.edu.ar/indexes/artic_v4703/Vol47_03_83.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:39Zoai:ri.conicet.gov.ar:11336/63446instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:40.163CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
title Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
spellingShingle Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
Fries, Exequiel
Ventricular assist device
blood damage
platelet activation
pulsatile flow
title_short Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
title_full Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
title_fullStr Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
title_full_unstemmed Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
title_sort Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry
dc.creator.none.fl_str_mv Fries, Exequiel
Berli, Marcelo Eduardo
Campana, Diego Martin
Ubal, Sebastian
Di Paolo, José
author Fries, Exequiel
author_facet Fries, Exequiel
Berli, Marcelo Eduardo
Campana, Diego Martin
Ubal, Sebastian
Di Paolo, José
author_role author
author2 Berli, Marcelo Eduardo
Campana, Diego Martin
Ubal, Sebastian
Di Paolo, José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ventricular assist device
blood damage
platelet activation
pulsatile flow
topic Ventricular assist device
blood damage
platelet activation
pulsatile flow
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.3
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Ventricular assist devices are a technological solution for patients who suffer from cardiac insufficiency and await a transplant. In this work, a new design of an implantable pulsatile blood pump is analyzed in terms of blood damage, by means of finite elements on a simplified geometry. It is a double effect volumetric pump, which has a noncontact driven piston and four active valves. The analysis is done by means of blood flow simulation into the pump and the prediction of platelets activation. The last is a measure of the pump compatibility with human life.The platelet activation state is evaluated by an equivalent or representative shear stress and compared with bibliographic data corresponding to other VAD kinds and cardiac prosthetic valves. The results show that, for the complementary blood flow rate supplied by the simulated VAD, the predicted platelet damage is in the same levels of current cardiac devices, particularly other VADs.
Fil: Fries, Exequiel. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Berli, Marcelo Eduardo. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Campana, Diego Martin. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
Fil: Ubal, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Di Paolo, José. Universidad Nacional de Entre Ríos. Facultad de Ingeniería. Departamento de Física Química. Laboratorio de Biomecánica Computacional; Argentina
description Ventricular assist devices are a technological solution for patients who suffer from cardiac insufficiency and await a transplant. In this work, a new design of an implantable pulsatile blood pump is analyzed in terms of blood damage, by means of finite elements on a simplified geometry. It is a double effect volumetric pump, which has a noncontact driven piston and four active valves. The analysis is done by means of blood flow simulation into the pump and the prediction of platelets activation. The last is a measure of the pump compatibility with human life.The platelet activation state is evaluated by an equivalent or representative shear stress and compared with bibliographic data corresponding to other VAD kinds and cardiac prosthetic valves. The results show that, for the complementary blood flow rate supplied by the simulated VAD, the predicted platelet damage is in the same levels of current cardiac devices, particularly other VADs.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63446
Fries, Exequiel; Berli, Marcelo Eduardo; Campana, Diego Martin; Ubal, Sebastian; Di Paolo, José; Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry; Plapiqui; Latin American Applied Research; 47; 3; 3-2017; 83-88
0327-0793
1851-8796
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63446
identifier_str_mv Fries, Exequiel; Berli, Marcelo Eduardo; Campana, Diego Martin; Ubal, Sebastian; Di Paolo, José; Computer simulation of platelet activation in a pulsatile ventricular assist device, through finite elements and a simplified geometry; Plapiqui; Latin American Applied Research; 47; 3; 3-2017; 83-88
0327-0793
1851-8796
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.laar.uns.edu.ar/indexes/artic_v4703/Vol47_03_83.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Plapiqui
publisher.none.fl_str_mv Plapiqui
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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