Acinetobacter baumannii response to cefiderocol challenge in human urine

Autores
Nishimura, Brent; Escalante, Jenny; Tuttobene, Marisel Romina; Subils, Tomás; Mezcord, Vyanka; Pimentel, Camila; Georgeos, Nardin; Pasteran, Fernando; Rodriguez, Maria Cecilia; Sieira, Rodrigo; Actis, Luis A.; Tolmasky, Marcelo E.; Bonomo, Robert A.; Ramirez, Maria Soledad
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cefiderocol (CFDC) is a novel chlorocatechol-substituted siderophore antibiotic approved to treatcomplicated urinary tract infections (cUTI) and hospital-acquired and ventilator-acquired pneumonia(HAP/VAP). Previous work determined that albumin-rich human fluids increase the minimuminhibitory concentration (MICs) of Acinetobacter baumannii against CFDC and reduce the expressionof genes related to iron uptake systems. This latter effect may contribute to the need for higherconcentrations of CFDC to inhibit growth. The presence of human urine (HU), which contains lowalbumin concentrations, did not modify MIC values of two carbapenem-resistant A. baumannii. Levelsof resistance to CFDC were not modified by HU in strain AMA40 but were reduced in strain AB5075.Expanding the studies to other carbapenem-resistant A. baumannii isolates showed that the presenceof HU resulted in unmodified or reduced MIC of CDFC values. The expression of piuA, pirA, bauA,and bfnH determined by qRT-PCR was enhanced in A. baumannii AMA40 and AB5075 by the presenceof HU in the culture medium. All four tested genes code for functions related to recognition andtransport of ferric-siderophore complexes. The effect of HU on expression of pbp1, pbp3, blaOXA-51-like, blaADC, and blaNDM-1, genes associated with resistance to β-lactams, as well as genes coding for efflux pumps and porins was variable, showing dependence with the strain analyzed. We conclude that the lack of significant concentrations of albumin and free iron in HU makes this fluid behave differently from others we tested. Unlike other albumin rich fluids, the presence of HU does not impact the antibacterial activity of CFDC when tested against A. baumannii.
Fil: Nishimura, Brent. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Escalante, Jenny. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Subils, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Químicos Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Procesos Biotecnológicos y Químicos Rosario; Argentina
Fil: Mezcord, Vyanka. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Pimentel, Camila. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Georgeos, Nardin. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Rodriguez, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Actis, Luis A.. Miami University; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Bonomo, Robert A.. Center for Antimicrobial Resistance and Epidemiology; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Ramirez, Maria Soledad. California State University. College Of Natural Science And Mathematics; Estados Unidos
Materia
ACINETOBACTER BAUMANNII
HUMAN URINE
CEFIDEROCOL
IRON
HUMAN SERUM ALBUMIN
CARBAPENEM-RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160423

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spelling Acinetobacter baumannii response to cefiderocol challenge in human urineNishimura, BrentEscalante, JennyTuttobene, Marisel RominaSubils, TomásMezcord, VyankaPimentel, CamilaGeorgeos, NardinPasteran, FernandoRodriguez, Maria CeciliaSieira, RodrigoActis, Luis A.Tolmasky, Marcelo E.Bonomo, Robert A.Ramirez, Maria SoledadACINETOBACTER BAUMANNIIHUMAN URINECEFIDEROCOLIRONHUMAN SERUM ALBUMINCARBAPENEM-RESISTANCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cefiderocol (CFDC) is a novel chlorocatechol-substituted siderophore antibiotic approved to treatcomplicated urinary tract infections (cUTI) and hospital-acquired and ventilator-acquired pneumonia(HAP/VAP). Previous work determined that albumin-rich human fluids increase the minimuminhibitory concentration (MICs) of Acinetobacter baumannii against CFDC and reduce the expressionof genes related to iron uptake systems. This latter effect may contribute to the need for higherconcentrations of CFDC to inhibit growth. The presence of human urine (HU), which contains lowalbumin concentrations, did not modify MIC values of two carbapenem-resistant A. baumannii. Levelsof resistance to CFDC were not modified by HU in strain AMA40 but were reduced in strain AB5075.Expanding the studies to other carbapenem-resistant A. baumannii isolates showed that the presenceof HU resulted in unmodified or reduced MIC of CDFC values. The expression of piuA, pirA, bauA,and bfnH determined by qRT-PCR was enhanced in A. baumannii AMA40 and AB5075 by the presenceof HU in the culture medium. All four tested genes code for functions related to recognition andtransport of ferric-siderophore complexes. The effect of HU on expression of pbp1, pbp3, blaOXA-51-like, blaADC, and blaNDM-1, genes associated with resistance to β-lactams, as well as genes coding for efflux pumps and porins was variable, showing dependence with the strain analyzed. We conclude that the lack of significant concentrations of albumin and free iron in HU makes this fluid behave differently from others we tested. Unlike other albumin rich fluids, the presence of HU does not impact the antibacterial activity of CFDC when tested against A. baumannii.Fil: Nishimura, Brent. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Escalante, Jenny. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Subils, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Químicos Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Procesos Biotecnológicos y Químicos Rosario; ArgentinaFil: Mezcord, Vyanka. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Pimentel, Camila. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Georgeos, Nardin. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Rodriguez, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Actis, Luis A.. Miami University; Estados UnidosFil: Tolmasky, Marcelo E.. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Bonomo, Robert A.. Center for Antimicrobial Resistance and Epidemiology; Estados Unidos. Case Western Reserve University; Estados UnidosFil: Ramirez, Maria Soledad. California State University. College Of Natural Science And Mathematics; Estados UnidosNature Publishing Group2022-05-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160423Nishimura, Brent; Escalante, Jenny; Tuttobene, Marisel Romina; Subils, Tomás; Mezcord, Vyanka; et al.; Acinetobacter baumannii response to cefiderocol challenge in human urine; Nature Publishing Group; Sicentific Reports; 12; 8763; 24-5-2022; 1-92045-23222045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1038/s41598-022-12829-7info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-022-12829-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:05Zoai:ri.conicet.gov.ar:11336/160423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:05.318CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acinetobacter baumannii response to cefiderocol challenge in human urine
title Acinetobacter baumannii response to cefiderocol challenge in human urine
spellingShingle Acinetobacter baumannii response to cefiderocol challenge in human urine
Nishimura, Brent
ACINETOBACTER BAUMANNII
HUMAN URINE
CEFIDEROCOL
IRON
HUMAN SERUM ALBUMIN
CARBAPENEM-RESISTANCE
title_short Acinetobacter baumannii response to cefiderocol challenge in human urine
title_full Acinetobacter baumannii response to cefiderocol challenge in human urine
title_fullStr Acinetobacter baumannii response to cefiderocol challenge in human urine
title_full_unstemmed Acinetobacter baumannii response to cefiderocol challenge in human urine
title_sort Acinetobacter baumannii response to cefiderocol challenge in human urine
dc.creator.none.fl_str_mv Nishimura, Brent
Escalante, Jenny
Tuttobene, Marisel Romina
Subils, Tomás
Mezcord, Vyanka
Pimentel, Camila
Georgeos, Nardin
Pasteran, Fernando
Rodriguez, Maria Cecilia
Sieira, Rodrigo
Actis, Luis A.
Tolmasky, Marcelo E.
Bonomo, Robert A.
Ramirez, Maria Soledad
author Nishimura, Brent
author_facet Nishimura, Brent
Escalante, Jenny
Tuttobene, Marisel Romina
Subils, Tomás
Mezcord, Vyanka
Pimentel, Camila
Georgeos, Nardin
Pasteran, Fernando
Rodriguez, Maria Cecilia
Sieira, Rodrigo
Actis, Luis A.
Tolmasky, Marcelo E.
Bonomo, Robert A.
Ramirez, Maria Soledad
author_role author
author2 Escalante, Jenny
Tuttobene, Marisel Romina
Subils, Tomás
Mezcord, Vyanka
Pimentel, Camila
Georgeos, Nardin
Pasteran, Fernando
Rodriguez, Maria Cecilia
Sieira, Rodrigo
Actis, Luis A.
Tolmasky, Marcelo E.
Bonomo, Robert A.
Ramirez, Maria Soledad
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACINETOBACTER BAUMANNII
HUMAN URINE
CEFIDEROCOL
IRON
HUMAN SERUM ALBUMIN
CARBAPENEM-RESISTANCE
topic ACINETOBACTER BAUMANNII
HUMAN URINE
CEFIDEROCOL
IRON
HUMAN SERUM ALBUMIN
CARBAPENEM-RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cefiderocol (CFDC) is a novel chlorocatechol-substituted siderophore antibiotic approved to treatcomplicated urinary tract infections (cUTI) and hospital-acquired and ventilator-acquired pneumonia(HAP/VAP). Previous work determined that albumin-rich human fluids increase the minimuminhibitory concentration (MICs) of Acinetobacter baumannii against CFDC and reduce the expressionof genes related to iron uptake systems. This latter effect may contribute to the need for higherconcentrations of CFDC to inhibit growth. The presence of human urine (HU), which contains lowalbumin concentrations, did not modify MIC values of two carbapenem-resistant A. baumannii. Levelsof resistance to CFDC were not modified by HU in strain AMA40 but were reduced in strain AB5075.Expanding the studies to other carbapenem-resistant A. baumannii isolates showed that the presenceof HU resulted in unmodified or reduced MIC of CDFC values. The expression of piuA, pirA, bauA,and bfnH determined by qRT-PCR was enhanced in A. baumannii AMA40 and AB5075 by the presenceof HU in the culture medium. All four tested genes code for functions related to recognition andtransport of ferric-siderophore complexes. The effect of HU on expression of pbp1, pbp3, blaOXA-51-like, blaADC, and blaNDM-1, genes associated with resistance to β-lactams, as well as genes coding for efflux pumps and porins was variable, showing dependence with the strain analyzed. We conclude that the lack of significant concentrations of albumin and free iron in HU makes this fluid behave differently from others we tested. Unlike other albumin rich fluids, the presence of HU does not impact the antibacterial activity of CFDC when tested against A. baumannii.
Fil: Nishimura, Brent. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Escalante, Jenny. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Subils, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Químicos Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Procesos Biotecnológicos y Químicos Rosario; Argentina
Fil: Mezcord, Vyanka. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Pimentel, Camila. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Georgeos, Nardin. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Rodriguez, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Actis, Luis A.. Miami University; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University. College Of Natural Science And Mathematics; Estados Unidos
Fil: Bonomo, Robert A.. Center for Antimicrobial Resistance and Epidemiology; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Ramirez, Maria Soledad. California State University. College Of Natural Science And Mathematics; Estados Unidos
description Cefiderocol (CFDC) is a novel chlorocatechol-substituted siderophore antibiotic approved to treatcomplicated urinary tract infections (cUTI) and hospital-acquired and ventilator-acquired pneumonia(HAP/VAP). Previous work determined that albumin-rich human fluids increase the minimuminhibitory concentration (MICs) of Acinetobacter baumannii against CFDC and reduce the expressionof genes related to iron uptake systems. This latter effect may contribute to the need for higherconcentrations of CFDC to inhibit growth. The presence of human urine (HU), which contains lowalbumin concentrations, did not modify MIC values of two carbapenem-resistant A. baumannii. Levelsof resistance to CFDC were not modified by HU in strain AMA40 but were reduced in strain AB5075.Expanding the studies to other carbapenem-resistant A. baumannii isolates showed that the presenceof HU resulted in unmodified or reduced MIC of CDFC values. The expression of piuA, pirA, bauA,and bfnH determined by qRT-PCR was enhanced in A. baumannii AMA40 and AB5075 by the presenceof HU in the culture medium. All four tested genes code for functions related to recognition andtransport of ferric-siderophore complexes. The effect of HU on expression of pbp1, pbp3, blaOXA-51-like, blaADC, and blaNDM-1, genes associated with resistance to β-lactams, as well as genes coding for efflux pumps and porins was variable, showing dependence with the strain analyzed. We conclude that the lack of significant concentrations of albumin and free iron in HU makes this fluid behave differently from others we tested. Unlike other albumin rich fluids, the presence of HU does not impact the antibacterial activity of CFDC when tested against A. baumannii.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160423
Nishimura, Brent; Escalante, Jenny; Tuttobene, Marisel Romina; Subils, Tomás; Mezcord, Vyanka; et al.; Acinetobacter baumannii response to cefiderocol challenge in human urine; Nature Publishing Group; Sicentific Reports; 12; 8763; 24-5-2022; 1-9
2045-2322
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160423
identifier_str_mv Nishimura, Brent; Escalante, Jenny; Tuttobene, Marisel Romina; Subils, Tomás; Mezcord, Vyanka; et al.; Acinetobacter baumannii response to cefiderocol challenge in human urine; Nature Publishing Group; Sicentific Reports; 12; 8763; 24-5-2022; 1-9
2045-2322
CONICET Digital
CONICET
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