Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam

Autores
Soria, Carlos A.; Remedi, Carolina; D`Alessio, Luciana; Roldán, Emilio J. A.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (−1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with ≥50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.
Fil: D`Alessio, Luciana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Soria, Carlos A.. Henri Laborit Institute Of Biosciences; Argentina
Fil: Remedi, Carolina. Henri Laborit Institute Of Biosciences; Argentina; Argentina
Fil: Roldán, Emilio J. A.. Instituto de Neurobiología IDNEU; Argentina
Materia
ALOSTATIC LOAD
NEUROTICISM
STRESS
GENERAL ANXIETY DISORDER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96367
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96367
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with AlprazolamSoria, Carlos A.Remedi, CarolinaD`Alessio, LucianaRoldán, Emilio J. A.ALOSTATIC LOADNEUROTICISMSTRESSGENERAL ANXIETY DISORDERhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (−1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with ≥50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.Fil: D`Alessio, Luciana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Soria, Carlos A.. Henri Laborit Institute Of Biosciences; ArgentinaFil: Remedi, Carolina. Henri Laborit Institute Of Biosciences; Argentina; ArgentinaFil: Roldán, Emilio J. A.. Instituto de Neurobiología IDNEU; ArgentinaScientific Research Publishing2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96367Soria, Carlos A.; Remedi, Carolina; D`Alessio, Luciana; Roldán, Emilio J. A.; Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam; Scientific Research Publishing; Open Journal of Psychiatry; 8; 3; 6-2018; 212-2322161-73252161-7333CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/paperinformation.aspx?paperid=85345info:eu-repo/semantics/altIdentifier/doi/10.4236/ojpsych.2018.83019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:23Zoai:ri.conicet.gov.ar:11336/96367instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:24.041CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
title Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
spellingShingle Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
Soria, Carlos A.
ALOSTATIC LOAD
NEUROTICISM
STRESS
GENERAL ANXIETY DISORDER
title_short Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
title_full Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
title_fullStr Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
title_full_unstemmed Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
title_sort Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
dc.creator.none.fl_str_mv Soria, Carlos A.
Remedi, Carolina
D`Alessio, Luciana
Roldán, Emilio J. A.
author Soria, Carlos A.
author_facet Soria, Carlos A.
Remedi, Carolina
D`Alessio, Luciana
Roldán, Emilio J. A.
author_role author
author2 Remedi, Carolina
D`Alessio, Luciana
Roldán, Emilio J. A.
author2_role author
author
author
dc.subject.none.fl_str_mv ALOSTATIC LOAD
NEUROTICISM
STRESS
GENERAL ANXIETY DISORDER
topic ALOSTATIC LOAD
NEUROTICISM
STRESS
GENERAL ANXIETY DISORDER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (−1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with ≥50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.
Fil: D`Alessio, Luciana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Soria, Carlos A.. Henri Laborit Institute Of Biosciences; Argentina
Fil: Remedi, Carolina. Henri Laborit Institute Of Biosciences; Argentina; Argentina
Fil: Roldán, Emilio J. A.. Instituto de Neurobiología IDNEU; Argentina
description Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (−1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with ≥50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96367
Soria, Carlos A.; Remedi, Carolina; D`Alessio, Luciana; Roldán, Emilio J. A.; Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam; Scientific Research Publishing; Open Journal of Psychiatry; 8; 3; 6-2018; 212-232
2161-7325
2161-7333
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96367
identifier_str_mv Soria, Carlos A.; Remedi, Carolina; D`Alessio, Luciana; Roldán, Emilio J. A.; Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam; Scientific Research Publishing; Open Journal of Psychiatry; 8; 3; 6-2018; 212-232
2161-7325
2161-7333
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/paperinformation.aspx?paperid=85345
info:eu-repo/semantics/altIdentifier/doi/10.4236/ojpsych.2018.83019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Research Publishing
publisher.none.fl_str_mv Scientific Research Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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