Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders

Autores
Fernández, Rodrigo Sebastián; Pedreira, Maria Eugenia; Boccia, Mariano Martín
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In normal settings, our brain is able to update its stored representations in content, strength, and/or expectations by the memory reconsolidation process. Thus, a reactivated memory enters in a transient labile state (destabilization) followed by a re-stabilization phase in order to persist (memory reconsolidation). Cognitive neuroscience and its insight into psychiatric problems attributed a close relationship between memory (formation, maintenance, and utilization) and several mental disorders. In this framework, the reconsolidation process could be not only the mechanism for maintenance of some psychopathologies, but also open a novel therapeutic window. Here we aim to integrate integrate recent experimental and theoretical research on memory reconsolidation and anxiety disorders maintenance. We propose a bayesian-like model about anxiety disorders persistence and postulate a new theoretical framework for how anxiety disorders are maintained through impaired memory updating due to a dysfunctional prediction error minimization strategy and anticipatory responses to threat.
Fil: Fernández, Rodrigo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Memory Reconsolidation
Learning Models
Bayesian Learning
Mental Disorders
Anxiety
Memory Schema
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47773
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disordersFernández, Rodrigo SebastiánPedreira, Maria EugeniaBoccia, Mariano MartínMemory ReconsolidationLearning ModelsBayesian LearningMental DisordersAnxietyMemory Schemahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In normal settings, our brain is able to update its stored representations in content, strength, and/or expectations by the memory reconsolidation process. Thus, a reactivated memory enters in a transient labile state (destabilization) followed by a re-stabilization phase in order to persist (memory reconsolidation). Cognitive neuroscience and its insight into psychiatric problems attributed a close relationship between memory (formation, maintenance, and utilization) and several mental disorders. In this framework, the reconsolidation process could be not only the mechanism for maintenance of some psychopathologies, but also open a novel therapeutic window. Here we aim to integrate integrate recent experimental and theoretical research on memory reconsolidation and anxiety disorders maintenance. We propose a bayesian-like model about anxiety disorders persistence and postulate a new theoretical framework for how anxiety disorders are maintained through impaired memory updating due to a dysfunctional prediction error minimization strategy and anticipatory responses to threat.Fil: Fernández, Rodrigo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaElsevier2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47773Fernández, Rodrigo Sebastián; Pedreira, Maria Eugenia; Boccia, Mariano Martín; Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders; Elsevier; Clinical Psychology Review; 57; 11-2017; 45-580272-7358CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cpr.2017.08.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0272735816304123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:26:47Zoai:ri.conicet.gov.ar:11336/47773instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:26:47.621CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
title Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
spellingShingle Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
Fernández, Rodrigo Sebastián
Memory Reconsolidation
Learning Models
Bayesian Learning
Mental Disorders
Anxiety
Memory Schema
title_short Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
title_full Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
title_fullStr Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
title_full_unstemmed Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
title_sort Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders
dc.creator.none.fl_str_mv Fernández, Rodrigo Sebastián
Pedreira, Maria Eugenia
Boccia, Mariano Martín
author Fernández, Rodrigo Sebastián
author_facet Fernández, Rodrigo Sebastián
Pedreira, Maria Eugenia
Boccia, Mariano Martín
author_role author
author2 Pedreira, Maria Eugenia
Boccia, Mariano Martín
author2_role author
author
dc.subject.none.fl_str_mv Memory Reconsolidation
Learning Models
Bayesian Learning
Mental Disorders
Anxiety
Memory Schema
topic Memory Reconsolidation
Learning Models
Bayesian Learning
Mental Disorders
Anxiety
Memory Schema
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In normal settings, our brain is able to update its stored representations in content, strength, and/or expectations by the memory reconsolidation process. Thus, a reactivated memory enters in a transient labile state (destabilization) followed by a re-stabilization phase in order to persist (memory reconsolidation). Cognitive neuroscience and its insight into psychiatric problems attributed a close relationship between memory (formation, maintenance, and utilization) and several mental disorders. In this framework, the reconsolidation process could be not only the mechanism for maintenance of some psychopathologies, but also open a novel therapeutic window. Here we aim to integrate integrate recent experimental and theoretical research on memory reconsolidation and anxiety disorders maintenance. We propose a bayesian-like model about anxiety disorders persistence and postulate a new theoretical framework for how anxiety disorders are maintained through impaired memory updating due to a dysfunctional prediction error minimization strategy and anticipatory responses to threat.
Fil: Fernández, Rodrigo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description In normal settings, our brain is able to update its stored representations in content, strength, and/or expectations by the memory reconsolidation process. Thus, a reactivated memory enters in a transient labile state (destabilization) followed by a re-stabilization phase in order to persist (memory reconsolidation). Cognitive neuroscience and its insight into psychiatric problems attributed a close relationship between memory (formation, maintenance, and utilization) and several mental disorders. In this framework, the reconsolidation process could be not only the mechanism for maintenance of some psychopathologies, but also open a novel therapeutic window. Here we aim to integrate integrate recent experimental and theoretical research on memory reconsolidation and anxiety disorders maintenance. We propose a bayesian-like model about anxiety disorders persistence and postulate a new theoretical framework for how anxiety disorders are maintained through impaired memory updating due to a dysfunctional prediction error minimization strategy and anticipatory responses to threat.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47773
Fernández, Rodrigo Sebastián; Pedreira, Maria Eugenia; Boccia, Mariano Martín; Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders; Elsevier; Clinical Psychology Review; 57; 11-2017; 45-58
0272-7358
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47773
identifier_str_mv Fernández, Rodrigo Sebastián; Pedreira, Maria Eugenia; Boccia, Mariano Martín; Does reconsolidation occur in natural settings? Memory reconsolidation and anxiety disorders; Elsevier; Clinical Psychology Review; 57; 11-2017; 45-58
0272-7358
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cpr.2017.08.004
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0272735816304123
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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