The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain

Autores
Tallini, Luciana R.; Manfredini, Giulia; Rodríguez Escobar, María Lenny; Ríos, Segundo; Martínez Francés, Vanessa; Feresin, Gabriela Egly; de Souza Borges, Warley; Bastida, Jaume; Viladomat, Francesc; Torras Claveria, Laura
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1, while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1.
Fil: Tallini, Luciana R.. Universidad de Barcelona; España
Fil: Manfredini, Giulia. Universidad de Barcelona; España
Fil: Rodríguez Escobar, María Lenny. Universidad de Barcelona; España
Fil: Ríos, Segundo. Universidad de Alicante; España
Fil: Martínez Francés, Vanessa. Universidad de Miguel Hernández; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Souza Borges, Warley. Universidade Federal do Espírito Santo; Brasil
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Viladomat, Francesc. Universidad de Barcelona; España
Fil: Torras Claveria, Laura. Universidad de Barcelona; España
Materia
ACETYLCHOLINESTERASE
AMARYLLIDACEAE
ALKALOIDS
ALZHEIMER’S DISEASE
BUTYRYLCHOLINESTERASE
NARCISSUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/235489
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/235489
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in SpainTallini, Luciana R.Manfredini, GiuliaRodríguez Escobar, María LennyRíos, SegundoMartínez Francés, VanessaFeresin, Gabriela Eglyde Souza Borges, WarleyBastida, JaumeViladomat, FrancescTorras Claveria, LauraACETYLCHOLINESTERASEAMARYLLIDACEAEALKALOIDSALZHEIMER’S DISEASEBUTYRYLCHOLINESTERASENARCISSUShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1, while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1.Fil: Tallini, Luciana R.. Universidad de Barcelona; EspañaFil: Manfredini, Giulia. Universidad de Barcelona; EspañaFil: Rodríguez Escobar, María Lenny. Universidad de Barcelona; EspañaFil: Ríos, Segundo. Universidad de Alicante; EspañaFil: Martínez Francés, Vanessa. Universidad de Miguel Hernández; EspañaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Souza Borges, Warley. Universidade Federal do Espírito Santo; BrasilFil: Bastida, Jaume. Universidad de Barcelona; EspañaFil: Viladomat, Francesc. Universidad de Barcelona; EspañaFil: Torras Claveria, Laura. Universidad de Barcelona; EspañaMDPI2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235489Tallini, Luciana R.; Manfredini, Giulia; Rodríguez Escobar, María Lenny; Ríos, Segundo; Martínez Francés, Vanessa; et al.; The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain; MDPI; Life; 14; 4; 4-2024; 1-152075-1729CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2075-1729/14/4/536info:eu-repo/semantics/altIdentifier/doi/10.3390/life14040536info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:32Zoai:ri.conicet.gov.ar:11336/235489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:33.068CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
title The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
spellingShingle The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
Tallini, Luciana R.
ACETYLCHOLINESTERASE
AMARYLLIDACEAE
ALKALOIDS
ALZHEIMER’S DISEASE
BUTYRYLCHOLINESTERASE
NARCISSUS
title_short The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
title_full The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
title_fullStr The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
title_full_unstemmed The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
title_sort The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
dc.creator.none.fl_str_mv Tallini, Luciana R.
Manfredini, Giulia
Rodríguez Escobar, María Lenny
Ríos, Segundo
Martínez Francés, Vanessa
Feresin, Gabriela Egly
de Souza Borges, Warley
Bastida, Jaume
Viladomat, Francesc
Torras Claveria, Laura
author Tallini, Luciana R.
author_facet Tallini, Luciana R.
Manfredini, Giulia
Rodríguez Escobar, María Lenny
Ríos, Segundo
Martínez Francés, Vanessa
Feresin, Gabriela Egly
de Souza Borges, Warley
Bastida, Jaume
Viladomat, Francesc
Torras Claveria, Laura
author_role author
author2 Manfredini, Giulia
Rodríguez Escobar, María Lenny
Ríos, Segundo
Martínez Francés, Vanessa
Feresin, Gabriela Egly
de Souza Borges, Warley
Bastida, Jaume
Viladomat, Francesc
Torras Claveria, Laura
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACETYLCHOLINESTERASE
AMARYLLIDACEAE
ALKALOIDS
ALZHEIMER’S DISEASE
BUTYRYLCHOLINESTERASE
NARCISSUS
topic ACETYLCHOLINESTERASE
AMARYLLIDACEAE
ALKALOIDS
ALZHEIMER’S DISEASE
BUTYRYLCHOLINESTERASE
NARCISSUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1, while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1.
Fil: Tallini, Luciana R.. Universidad de Barcelona; España
Fil: Manfredini, Giulia. Universidad de Barcelona; España
Fil: Rodríguez Escobar, María Lenny. Universidad de Barcelona; España
Fil: Ríos, Segundo. Universidad de Alicante; España
Fil: Martínez Francés, Vanessa. Universidad de Miguel Hernández; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Souza Borges, Warley. Universidade Federal do Espírito Santo; Brasil
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Viladomat, Francesc. Universidad de Barcelona; España
Fil: Torras Claveria, Laura. Universidad de Barcelona; España
description Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1, while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/235489
Tallini, Luciana R.; Manfredini, Giulia; Rodríguez Escobar, María Lenny; Ríos, Segundo; Martínez Francés, Vanessa; et al.; The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain; MDPI; Life; 14; 4; 4-2024; 1-15
2075-1729
CONICET Digital
CONICET
url http://hdl.handle.net/11336/235489
identifier_str_mv Tallini, Luciana R.; Manfredini, Giulia; Rodríguez Escobar, María Lenny; Ríos, Segundo; Martínez Francés, Vanessa; et al.; The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain; MDPI; Life; 14; 4; 4-2024; 1-15
2075-1729
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2075-1729/14/4/536
info:eu-repo/semantics/altIdentifier/doi/10.3390/life14040536
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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