Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario

Autores
Fernandez, Ariel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Deactivation of primed SARS-CoV-2 prior to cell entry constitutes an emergency brake in COVID-19 infection if vaccine-induced antibodies fail to block recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor. The timing and locus for the therapeutic intervention are dictated by the cell entry mechanism and by the selective advantage of the dominant D614G mutation.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
SARS-CoV-2
COVID-19
antibody
virus transmissibility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/121495
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure ScenarioFernandez, ArielSARS-CoV-2COVID-19antibodyvirus transmissibilityhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Deactivation of primed SARS-CoV-2 prior to cell entry constitutes an emergency brake in COVID-19 infection if vaccine-induced antibodies fail to block recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor. The timing and locus for the therapeutic intervention are dictated by the cell entry mechanism and by the selective advantage of the dominant D614G mutation.Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaAmerican Chemical Society Inc2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/121495Fernandez, Ariel; Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario; American Chemical Society Inc; ACS Pharmacology and Translational Science; 3; 12-2020; 1425-14262575-9108CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsptsci.0c00152info:eu-repo/semantics/altIdentifier/doi/10.1021/acsptsci.0c00152info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:45Zoai:ri.conicet.gov.ar:11336/121495instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:46.115CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
title Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
spellingShingle Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
Fernandez, Ariel
SARS-CoV-2
COVID-19
antibody
virus transmissibility
title_short Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
title_full Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
title_fullStr Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
title_full_unstemmed Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
title_sort Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario
dc.creator.none.fl_str_mv Fernandez, Ariel
author Fernandez, Ariel
author_facet Fernandez, Ariel
author_role author
dc.subject.none.fl_str_mv SARS-CoV-2
COVID-19
antibody
virus transmissibility
topic SARS-CoV-2
COVID-19
antibody
virus transmissibility
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Deactivation of primed SARS-CoV-2 prior to cell entry constitutes an emergency brake in COVID-19 infection if vaccine-induced antibodies fail to block recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor. The timing and locus for the therapeutic intervention are dictated by the cell entry mechanism and by the selective advantage of the dominant D614G mutation.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description Deactivation of primed SARS-CoV-2 prior to cell entry constitutes an emergency brake in COVID-19 infection if vaccine-induced antibodies fail to block recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor. The timing and locus for the therapeutic intervention are dictated by the cell entry mechanism and by the selective advantage of the dominant D614G mutation.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/121495
Fernandez, Ariel; Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario; American Chemical Society Inc; ACS Pharmacology and Translational Science; 3; 12-2020; 1425-1426
2575-9108
CONICET Digital
CONICET
url http://hdl.handle.net/11336/121495
identifier_str_mv Fernandez, Ariel; Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario; American Chemical Society Inc; ACS Pharmacology and Translational Science; 3; 12-2020; 1425-1426
2575-9108
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsptsci.0c00152
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsptsci.0c00152
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society Inc
publisher.none.fl_str_mv American Chemical Society Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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