Role of Platelets in Angiogenesis in Health and Disease

Autores
Etulain, Julia; Negrotto, Soledad; Schattner, Mirta Ana
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Increasing experimental and clinical research suggests a role for platelets in angiogenesis. These cells are major storage and delivery vehicles of a broad array of growth factors, chemokines, cytokines, proteases and cell adhesion molecules, which are secreted upon activation and determine the local angiogenic stimulus. Although platelets contain both, pro- and antiangiogenic molecules, there is a general consensus that platelets promote angiogenesis by stimulating chemotaxis, proliferation, and differentiation of endothelial cells and recruitment of progenitor cells to sites of vascular injury. However, a growing body of evidence indicates that the angiogenic proteome of platelets can be modified under stressful microenvironmental conditions such as cancer. How platelets regulate angiogenesis in different clinical scenarios is not completely understood. The amplification of angiogenesis by platelets plays a positive and beneficial role in several processes, such as pregnancy and tissue healing, where new vessel development is required. However, in clinical conditions associated with abnormal or excessive angiogenesis including cancer, atherosclerosis, and arthritis, platelets might contribute to the detrimental progression of these diseases. This review represents an integrated summary of the current knowledge regarding the role of platelets in angiogenesis and its consequences in health and disease.
Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Negrotto, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Alpha-Granules
Angiogenesis
Cancer
Endothelial Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29403
Acceder
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spelling Role of Platelets in Angiogenesis in Health and DiseaseEtulain, JuliaNegrotto, SoledadSchattner, Mirta AnaAlpha-GranulesAngiogenesisCancerEndothelial Cellshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Increasing experimental and clinical research suggests a role for platelets in angiogenesis. These cells are major storage and delivery vehicles of a broad array of growth factors, chemokines, cytokines, proteases and cell adhesion molecules, which are secreted upon activation and determine the local angiogenic stimulus. Although platelets contain both, pro- and antiangiogenic molecules, there is a general consensus that platelets promote angiogenesis by stimulating chemotaxis, proliferation, and differentiation of endothelial cells and recruitment of progenitor cells to sites of vascular injury. However, a growing body of evidence indicates that the angiogenic proteome of platelets can be modified under stressful microenvironmental conditions such as cancer. How platelets regulate angiogenesis in different clinical scenarios is not completely understood. The amplification of angiogenesis by platelets plays a positive and beneficial role in several processes, such as pregnancy and tissue healing, where new vessel development is required. However, in clinical conditions associated with abnormal or excessive angiogenesis including cancer, atherosclerosis, and arthritis, platelets might contribute to the detrimental progression of these diseases. This review represents an integrated summary of the current knowledge regarding the role of platelets in angiogenesis and its consequences in health and disease.Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Negrotto, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaBentham Science Publishers2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29403Etulain, Julia; Negrotto, Soledad; Schattner, Mirta Ana; Role of Platelets in Angiogenesis in Health and Disease ; Bentham Science Publishers; Current Angiogenesis; 3; 1; 2-2014; 48-572211-5528CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/2211552802666140404002756info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/121392/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:27Zoai:ri.conicet.gov.ar:11336/29403instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:27.811CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of Platelets in Angiogenesis in Health and Disease
title Role of Platelets in Angiogenesis in Health and Disease
spellingShingle Role of Platelets in Angiogenesis in Health and Disease
Etulain, Julia
Alpha-Granules
Angiogenesis
Cancer
Endothelial Cells
title_short Role of Platelets in Angiogenesis in Health and Disease
title_full Role of Platelets in Angiogenesis in Health and Disease
title_fullStr Role of Platelets in Angiogenesis in Health and Disease
title_full_unstemmed Role of Platelets in Angiogenesis in Health and Disease
title_sort Role of Platelets in Angiogenesis in Health and Disease
dc.creator.none.fl_str_mv Etulain, Julia
Negrotto, Soledad
Schattner, Mirta Ana
author Etulain, Julia
author_facet Etulain, Julia
Negrotto, Soledad
Schattner, Mirta Ana
author_role author
author2 Negrotto, Soledad
Schattner, Mirta Ana
author2_role author
author
dc.subject.none.fl_str_mv Alpha-Granules
Angiogenesis
Cancer
Endothelial Cells
topic Alpha-Granules
Angiogenesis
Cancer
Endothelial Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Increasing experimental and clinical research suggests a role for platelets in angiogenesis. These cells are major storage and delivery vehicles of a broad array of growth factors, chemokines, cytokines, proteases and cell adhesion molecules, which are secreted upon activation and determine the local angiogenic stimulus. Although platelets contain both, pro- and antiangiogenic molecules, there is a general consensus that platelets promote angiogenesis by stimulating chemotaxis, proliferation, and differentiation of endothelial cells and recruitment of progenitor cells to sites of vascular injury. However, a growing body of evidence indicates that the angiogenic proteome of platelets can be modified under stressful microenvironmental conditions such as cancer. How platelets regulate angiogenesis in different clinical scenarios is not completely understood. The amplification of angiogenesis by platelets plays a positive and beneficial role in several processes, such as pregnancy and tissue healing, where new vessel development is required. However, in clinical conditions associated with abnormal or excessive angiogenesis including cancer, atherosclerosis, and arthritis, platelets might contribute to the detrimental progression of these diseases. This review represents an integrated summary of the current knowledge regarding the role of platelets in angiogenesis and its consequences in health and disease.
Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Negrotto, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Increasing experimental and clinical research suggests a role for platelets in angiogenesis. These cells are major storage and delivery vehicles of a broad array of growth factors, chemokines, cytokines, proteases and cell adhesion molecules, which are secreted upon activation and determine the local angiogenic stimulus. Although platelets contain both, pro- and antiangiogenic molecules, there is a general consensus that platelets promote angiogenesis by stimulating chemotaxis, proliferation, and differentiation of endothelial cells and recruitment of progenitor cells to sites of vascular injury. However, a growing body of evidence indicates that the angiogenic proteome of platelets can be modified under stressful microenvironmental conditions such as cancer. How platelets regulate angiogenesis in different clinical scenarios is not completely understood. The amplification of angiogenesis by platelets plays a positive and beneficial role in several processes, such as pregnancy and tissue healing, where new vessel development is required. However, in clinical conditions associated with abnormal or excessive angiogenesis including cancer, atherosclerosis, and arthritis, platelets might contribute to the detrimental progression of these diseases. This review represents an integrated summary of the current knowledge regarding the role of platelets in angiogenesis and its consequences in health and disease.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29403
Etulain, Julia; Negrotto, Soledad; Schattner, Mirta Ana; Role of Platelets in Angiogenesis in Health and Disease ; Bentham Science Publishers; Current Angiogenesis; 3; 1; 2-2014; 48-57
2211-5528
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29403
identifier_str_mv Etulain, Julia; Negrotto, Soledad; Schattner, Mirta Ana; Role of Platelets in Angiogenesis in Health and Disease ; Bentham Science Publishers; Current Angiogenesis; 3; 1; 2-2014; 48-57
2211-5528
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/2211552802666140404002756
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/121392/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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