Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor

Autores
Durán, Gema M.; Benavidez, Tomás Enrique; Contento, Ana M.; Ríos, Angel; Garcia, Carlos D.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.
Fil: Durán, Gema M.. Universidad de Castilla-La Mancha; España
Fil: Benavidez, Tomás Enrique. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Contento, Ana M.. Universidad de Castilla-La Mancha; España
Fil: Ríos, Angel. Universidad de Castilla-La Mancha; España
Fil: Garcia, Carlos D.. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
FLUORESCENCE QUENCHING
GRAPHENE QUANTUM DOTS
ONE-STEP SYNTHESIS
PENICILLAMINE
PHARMACEUTICAL PREPARATIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82021
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursorDurán, Gema M.Benavidez, Tomás EnriqueContento, Ana M.Ríos, AngelGarcia, Carlos D.FLUORESCENCE QUENCHINGGRAPHENE QUANTUM DOTSONE-STEP SYNTHESISPENICILLAMINEPHARMACEUTICAL PREPARATIONShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.Fil: Durán, Gema M.. Universidad de Castilla-La Mancha; EspañaFil: Benavidez, Tomás Enrique. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Contento, Ana M.. Universidad de Castilla-La Mancha; EspañaFil: Ríos, Angel. Universidad de Castilla-La Mancha; EspañaFil: Garcia, Carlos D.. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaXi'an Jiaotong University2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/82021Durán, Gema M.; Benavidez, Tomás Enrique; Contento, Ana M.; Ríos, Angel; Garcia, Carlos D.; Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor; Xi'an Jiaotong University; Journal of Pharmaceutical Analysis; 7; 5; 10-2017; 324-3312095-1779CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpha.2017.07.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2095177917300783info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:35:20Zoai:ri.conicet.gov.ar:11336/82021instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:35:20.93CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
title Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
spellingShingle Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
Durán, Gema M.
FLUORESCENCE QUENCHING
GRAPHENE QUANTUM DOTS
ONE-STEP SYNTHESIS
PENICILLAMINE
PHARMACEUTICAL PREPARATIONS
title_short Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
title_full Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
title_fullStr Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
title_full_unstemmed Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
title_sort Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
dc.creator.none.fl_str_mv Durán, Gema M.
Benavidez, Tomás Enrique
Contento, Ana M.
Ríos, Angel
Garcia, Carlos D.
author Durán, Gema M.
author_facet Durán, Gema M.
Benavidez, Tomás Enrique
Contento, Ana M.
Ríos, Angel
Garcia, Carlos D.
author_role author
author2 Benavidez, Tomás Enrique
Contento, Ana M.
Ríos, Angel
Garcia, Carlos D.
author2_role author
author
author
author
dc.subject.none.fl_str_mv FLUORESCENCE QUENCHING
GRAPHENE QUANTUM DOTS
ONE-STEP SYNTHESIS
PENICILLAMINE
PHARMACEUTICAL PREPARATIONS
topic FLUORESCENCE QUENCHING
GRAPHENE QUANTUM DOTS
ONE-STEP SYNTHESIS
PENICILLAMINE
PHARMACEUTICAL PREPARATIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.
Fil: Durán, Gema M.. Universidad de Castilla-La Mancha; España
Fil: Benavidez, Tomás Enrique. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Contento, Ana M.. Universidad de Castilla-La Mancha; España
Fil: Ríos, Angel. Universidad de Castilla-La Mancha; España
Fil: Garcia, Carlos D.. Clemson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82021
Durán, Gema M.; Benavidez, Tomás Enrique; Contento, Ana M.; Ríos, Angel; Garcia, Carlos D.; Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor; Xi'an Jiaotong University; Journal of Pharmaceutical Analysis; 7; 5; 10-2017; 324-331
2095-1779
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82021
identifier_str_mv Durán, Gema M.; Benavidez, Tomás Enrique; Contento, Ana M.; Ríos, Angel; Garcia, Carlos D.; Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor; Xi'an Jiaotong University; Journal of Pharmaceutical Analysis; 7; 5; 10-2017; 324-331
2095-1779
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpha.2017.07.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2095177917300783
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Xi'an Jiaotong University
publisher.none.fl_str_mv Xi'an Jiaotong University
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847976776947466240
score 13.087074

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