Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control

Autores
Muñoz, G. G.; Millicovsky, Martín Javier; Reta, J. M.; Cerrudo, Juan Ignacio; Peñalva, A.; Machtey, Matías; Torres, R. M.; Zalazar, M. A.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Advances in sensors have revolutionized the biomedical engineering field, having an extreme affinity for specific analytes also providing an effective, real-time, point-of-care testing for an accurate diagnosis. Quartz Crystal Microbalance (QCM) is a well-established sensor that has been successfully applied in a broad range of applications to monitor and explore various surface interactions, in situ thin-film formations, and layer properties. This technology has gained interest in biomedical applications since novel QCM systems are able to work in liquid media. QCM with dissipation monitoring (QCM-D) is an expanded version of a QCM that measures changes in damping properties of adsorbed layers thus providing information on its viscoelastic nature. In this article, an open source and low cost QCM-D prototype for biomedical applications was developed. In addition, the system was validated using different Polyethylene Glycol (PEG) concentrations due to its importance for many medical applications. The statistics show a bigger dissipation of the system as the fluid becomes more viscous, also having a very acceptable sensibility when temperature is controlled.
Fil: Muñoz, G. G.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Millicovsky, Martín Javier. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Reta, J. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Cerrudo, Juan Ignacio. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Peñalva, A.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Machtey, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Torres, R. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Zalazar, M. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Materia
BIOMEDICAL APPLICATIONS
DISSIPATION MONITORING
QUARTZ CRYSTAL MICROBALANCE
TEMPERATURE CONTROL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225889
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/225889
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature controlMuñoz, G. G.Millicovsky, Martín JavierReta, J. M.Cerrudo, Juan IgnacioPeñalva, A.Machtey, MatíasTorres, R. M.Zalazar, M. A.BIOMEDICAL APPLICATIONSDISSIPATION MONITORINGQUARTZ CRYSTAL MICROBALANCETEMPERATURE CONTROLhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Advances in sensors have revolutionized the biomedical engineering field, having an extreme affinity for specific analytes also providing an effective, real-time, point-of-care testing for an accurate diagnosis. Quartz Crystal Microbalance (QCM) is a well-established sensor that has been successfully applied in a broad range of applications to monitor and explore various surface interactions, in situ thin-film formations, and layer properties. This technology has gained interest in biomedical applications since novel QCM systems are able to work in liquid media. QCM with dissipation monitoring (QCM-D) is an expanded version of a QCM that measures changes in damping properties of adsorbed layers thus providing information on its viscoelastic nature. In this article, an open source and low cost QCM-D prototype for biomedical applications was developed. In addition, the system was validated using different Polyethylene Glycol (PEG) concentrations due to its importance for many medical applications. The statistics show a bigger dissipation of the system as the fluid becomes more viscous, also having a very acceptable sensibility when temperature is controlled.Fil: Muñoz, G. G.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Millicovsky, Martín Javier. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Reta, J. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Cerrudo, Juan Ignacio. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Peñalva, A.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Machtey, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Torres, R. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Zalazar, M. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaElsevier2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225889Muñoz, G. G.; Millicovsky, Martín Javier; Reta, J. M.; Cerrudo, Juan Ignacio; Peñalva, A.; et al.; Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control; Elsevier; HardwareX; 14; 6-2023; 1-162468-0672CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468067223000238info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ohx.2023.e00416info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:34Zoai:ri.conicet.gov.ar:11336/225889instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:34.646CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
title Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
spellingShingle Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
Muñoz, G. G.
BIOMEDICAL APPLICATIONS
DISSIPATION MONITORING
QUARTZ CRYSTAL MICROBALANCE
TEMPERATURE CONTROL
title_short Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
title_full Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
title_fullStr Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
title_full_unstemmed Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
title_sort Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control
dc.creator.none.fl_str_mv Muñoz, G. G.
Millicovsky, Martín Javier
Reta, J. M.
Cerrudo, Juan Ignacio
Peñalva, A.
Machtey, Matías
Torres, R. M.
Zalazar, M. A.
author Muñoz, G. G.
author_facet Muñoz, G. G.
Millicovsky, Martín Javier
Reta, J. M.
Cerrudo, Juan Ignacio
Peñalva, A.
Machtey, Matías
Torres, R. M.
Zalazar, M. A.
author_role author
author2 Millicovsky, Martín Javier
Reta, J. M.
Cerrudo, Juan Ignacio
Peñalva, A.
Machtey, Matías
Torres, R. M.
Zalazar, M. A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMEDICAL APPLICATIONS
DISSIPATION MONITORING
QUARTZ CRYSTAL MICROBALANCE
TEMPERATURE CONTROL
topic BIOMEDICAL APPLICATIONS
DISSIPATION MONITORING
QUARTZ CRYSTAL MICROBALANCE
TEMPERATURE CONTROL
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Advances in sensors have revolutionized the biomedical engineering field, having an extreme affinity for specific analytes also providing an effective, real-time, point-of-care testing for an accurate diagnosis. Quartz Crystal Microbalance (QCM) is a well-established sensor that has been successfully applied in a broad range of applications to monitor and explore various surface interactions, in situ thin-film formations, and layer properties. This technology has gained interest in biomedical applications since novel QCM systems are able to work in liquid media. QCM with dissipation monitoring (QCM-D) is an expanded version of a QCM that measures changes in damping properties of adsorbed layers thus providing information on its viscoelastic nature. In this article, an open source and low cost QCM-D prototype for biomedical applications was developed. In addition, the system was validated using different Polyethylene Glycol (PEG) concentrations due to its importance for many medical applications. The statistics show a bigger dissipation of the system as the fluid becomes more viscous, also having a very acceptable sensibility when temperature is controlled.
Fil: Muñoz, G. G.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Millicovsky, Martín Javier. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Reta, J. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Cerrudo, Juan Ignacio. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Peñalva, A.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Machtey, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Torres, R. M.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Zalazar, M. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
description Advances in sensors have revolutionized the biomedical engineering field, having an extreme affinity for specific analytes also providing an effective, real-time, point-of-care testing for an accurate diagnosis. Quartz Crystal Microbalance (QCM) is a well-established sensor that has been successfully applied in a broad range of applications to monitor and explore various surface interactions, in situ thin-film formations, and layer properties. This technology has gained interest in biomedical applications since novel QCM systems are able to work in liquid media. QCM with dissipation monitoring (QCM-D) is an expanded version of a QCM that measures changes in damping properties of adsorbed layers thus providing information on its viscoelastic nature. In this article, an open source and low cost QCM-D prototype for biomedical applications was developed. In addition, the system was validated using different Polyethylene Glycol (PEG) concentrations due to its importance for many medical applications. The statistics show a bigger dissipation of the system as the fluid becomes more viscous, also having a very acceptable sensibility when temperature is controlled.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225889
Muñoz, G. G.; Millicovsky, Martín Javier; Reta, J. M.; Cerrudo, Juan Ignacio; Peñalva, A.; et al.; Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control; Elsevier; HardwareX; 14; 6-2023; 1-16
2468-0672
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225889
identifier_str_mv Muñoz, G. G.; Millicovsky, Martín Javier; Reta, J. M.; Cerrudo, Juan Ignacio; Peñalva, A.; et al.; Quartz crystal Microbalance with dissipation monitoring for biomedical applications: Open source and low cost prototype with active temperature control; Elsevier; HardwareX; 14; 6-2023; 1-16
2468-0672
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468067223000238
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ohx.2023.e00416
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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