ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas

Autores
Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; Barbazan, J.; Gonzalez, M.; Schoumacher, M.; Pedrola, N.; Ertekin, T.; Devis, L.; Ruiz, A.; Castellvi, J.; Doll, A.; Gil Moreno, A,; Vazquez, Monica Hebe; Lapyckyj, Lara; Lopez Lopez, R.; Robine, S.; Friederich, E.; Castro, M.; Reventos, J.; Vignjevic, D.; Abal, M.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.
Fil: Colas, E.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
Fil: Muinelo Romay, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Alonso Alconada, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Llaurado, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Monge, M,. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Barbazan, J.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Gonzalez, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Schoumacher, M.. Institute Curie; Francia
Fil: Pedrola, N.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ertekin, T.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Devis, L.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ruiz, A.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Castellvi, J.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Doll, A.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Gil Moreno, A,. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universidad de Barcelona; España
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lopez Lopez, R.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Robine, S.. Institute Curie; Francia
Fil: Friederich, E.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Castro, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Reventos, J.. Universidad de Santiago de Compostela; España. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Vignjevic, D.. Institute Curie; Francia
Fil: Abal, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Complexo Hospitalario Universitario de Santiago SERGAS;; España
Materia
Etv5
Endometrial Carcinoma
Lpp
Emt
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22664
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22664
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomasColas, E.Muinelo Romay, L.Alonso Alconada, L.Llaurado, M.Monge, M,Barbazan, J.Gonzalez, M.Schoumacher, M.Pedrola, N.Ertekin, T.Devis, L.Ruiz, A.Castellvi, J.Doll, A.Gil Moreno, A,Vazquez, Monica HebeLapyckyj, LaraLopez Lopez, R.Robine, S.Friederich, E.Castro, M.Reventos, J.Vignjevic, D.Abal, M.Etv5Endometrial CarcinomaLppEmthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.Fil: Colas, E.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; EspañaFil: Muinelo Romay, L.. Complexo Hospitalario Universitario de Santiago SERGAS; EspañaFil: Alonso Alconada, L.. Complexo Hospitalario Universitario de Santiago SERGAS; EspañaFil: Llaurado, M.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Monge, M,. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Barbazan, J.. Complexo Hospitalario Universitario de Santiago SERGAS; EspañaFil: Gonzalez, M.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Schoumacher, M.. Institute Curie; FranciaFil: Pedrola, N.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Ertekin, T.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Devis, L.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Ruiz, A.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Castellvi, J.. Universidad Autónoma de Barcelona. Hospital Vall D; EspañaFil: Doll, A.. Universidad Autónoma de Barcelona. Hospital Vall D; EspañaFil: Gil Moreno, A,. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universidad de Barcelona; EspañaFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lopez Lopez, R.. Complexo Hospitalario Universitario de Santiago SERGAS; EspañaFil: Robine, S.. Institute Curie; FranciaFil: Friederich, E.. Complexo Hospitalario Universitario de Santiago SERGAS; EspañaFil: Castro, M.. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Reventos, J.. Universidad de Santiago de Compostela; España. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Vignjevic, D.. Institute Curie; FranciaFil: Abal, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Complexo Hospitalario Universitario de Santiago SERGAS;; EspañaNature Publishing Group2012-01-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22664Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; et al.; ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas; Nature Publishing Group; Oncogene; 31; 23-1-2012; 4778-47880950-92321476-5594CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/onc/journal/v31/n45/full/onc2011632a.html?foxtrotcallback=trueinfo:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2011.632info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:11Zoai:ri.conicet.gov.ar:11336/22664instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:11.595CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
title ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
spellingShingle ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
Colas, E.
Etv5
Endometrial Carcinoma
Lpp
Emt
title_short ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
title_full ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
title_fullStr ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
title_full_unstemmed ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
title_sort ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
dc.creator.none.fl_str_mv Colas, E.
Muinelo Romay, L.
Alonso Alconada, L.
Llaurado, M.
Monge, M,
Barbazan, J.
Gonzalez, M.
Schoumacher, M.
Pedrola, N.
Ertekin, T.
Devis, L.
Ruiz, A.
Castellvi, J.
Doll, A.
Gil Moreno, A,
Vazquez, Monica Hebe
Lapyckyj, Lara
Lopez Lopez, R.
Robine, S.
Friederich, E.
Castro, M.
Reventos, J.
Vignjevic, D.
Abal, M.
author Colas, E.
author_facet Colas, E.
Muinelo Romay, L.
Alonso Alconada, L.
Llaurado, M.
Monge, M,
Barbazan, J.
Gonzalez, M.
Schoumacher, M.
Pedrola, N.
Ertekin, T.
Devis, L.
Ruiz, A.
Castellvi, J.
Doll, A.
Gil Moreno, A,
Vazquez, Monica Hebe
Lapyckyj, Lara
Lopez Lopez, R.
Robine, S.
Friederich, E.
Castro, M.
Reventos, J.
Vignjevic, D.
Abal, M.
author_role author
author2 Muinelo Romay, L.
Alonso Alconada, L.
Llaurado, M.
Monge, M,
Barbazan, J.
Gonzalez, M.
Schoumacher, M.
Pedrola, N.
Ertekin, T.
Devis, L.
Ruiz, A.
Castellvi, J.
Doll, A.
Gil Moreno, A,
Vazquez, Monica Hebe
Lapyckyj, Lara
Lopez Lopez, R.
Robine, S.
Friederich, E.
Castro, M.
Reventos, J.
Vignjevic, D.
Abal, M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Etv5
Endometrial Carcinoma
Lpp
Emt
topic Etv5
Endometrial Carcinoma
Lpp
Emt
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.
Fil: Colas, E.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
Fil: Muinelo Romay, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Alonso Alconada, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Llaurado, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Monge, M,. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Barbazan, J.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Gonzalez, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Schoumacher, M.. Institute Curie; Francia
Fil: Pedrola, N.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ertekin, T.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Devis, L.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Ruiz, A.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Castellvi, J.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Doll, A.. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Gil Moreno, A,. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universidad de Barcelona; España
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lopez Lopez, R.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Robine, S.. Institute Curie; Francia
Fil: Friederich, E.. Complexo Hospitalario Universitario de Santiago SERGAS; España
Fil: Castro, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Reventos, J.. Universidad de Santiago de Compostela; España. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Vignjevic, D.. Institute Curie; Francia
Fil: Abal, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Complexo Hospitalario Universitario de Santiago SERGAS;; España
description Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22664
Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; et al.; ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas; Nature Publishing Group; Oncogene; 31; 23-1-2012; 4778-4788
0950-9232
1476-5594
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22664
identifier_str_mv Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; et al.; ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas; Nature Publishing Group; Oncogene; 31; 23-1-2012; 4778-4788
0950-9232
1476-5594
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/onc/journal/v31/n45/full/onc2011632a.html?foxtrotcallback=true
info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2011.632
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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