ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination

Autores
Llaurado, Marta; Abal, Miguel; Castellví, Josep; Cabrera, Silvia; Gil Moreno, Antonio; Pérez Benavente, Asumpció; Colás, Eva; Doll, Andreas; Dolcet, Xavier; Matias Guiu, Xavier; Vazquez, Monica Hebe; Reventós, Jaume; Ruiz, Anna
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those that control cellular proliferation, differentiation, apoptosis, tissue remodeling, angiogenesis and transformation. ETV5 belongs to the PEA3 subfamily. PEA3 subfamily members are able to activate the transcription of proteases, matrix metalloproteinases and tissue inhibitor of metalloproteases, which is central to both tumor invasion and angiogenesis. Here, we examined the role of the ETV5 transcription factor in epithelial ovarian cancer and we found ETV5 was upregulated in ovarian tumor samples compared to ovarian tissue controls. The in vitro inhibition of ETV5 decreased cell proliferation in serum-deprived conditions, induced EMT and cell migration and decreased cell adhesion to extracellular matrix components. ETV5 inhibition also decreased cell–cell adhesion and induced apoptosis in anchorage-independent conditions. Accordingly, upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. Our findings suggest that the overexpression of ETV5 detected in ovarian cancer cells may contribute to ovarian tumor progression through the ability of ETV5 to enhance proliferation of ovarian cancer cells. In addition, upregulation of ETV5 would play a role in ovarian cancer cell dissemination and metastasis into the peritoneal cavity by protecting ovarian cancer cells from apoptosis and by increasing the adhesion of ovarian cancer cells to the peritoneal wall through the regulation of cell adhesion molecules.
Fil: Llaurado, Marta. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Abal, Miguel. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Castellví, Josep. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Cabrera, Silvia. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Gil Moreno, Antonio. Universitat Autònoma de Barcelona; España. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Pérez Benavente, Asumpció. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Colás, Eva. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Doll, Andreas. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Dolcet, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; España
Fil: Matias Guiu, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; España
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Reventós, Jaume. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
Fil: Ruiz, Anna. Universidad Autonoma de Barcelona. Hospital Vall D; España
Materia
Ovarian Cancer
Etv5
Epithelial Cadherin
Emt
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22269
Acceder
id CONICETDig_2c489cf933ff7c767b19b1da9092d256
oai_identifier_str oai:ri.conicet.gov.ar:11336/22269
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and disseminationLlaurado, MartaAbal, MiguelCastellví, JosepCabrera, SilviaGil Moreno, AntonioPérez Benavente, AsumpcióColás, EvaDoll, AndreasDolcet, XavierMatias Guiu, XavierVazquez, Monica HebeReventós, JaumeRuiz, AnnaOvarian CancerEtv5Epithelial CadherinEmthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those that control cellular proliferation, differentiation, apoptosis, tissue remodeling, angiogenesis and transformation. ETV5 belongs to the PEA3 subfamily. PEA3 subfamily members are able to activate the transcription of proteases, matrix metalloproteinases and tissue inhibitor of metalloproteases, which is central to both tumor invasion and angiogenesis. Here, we examined the role of the ETV5 transcription factor in epithelial ovarian cancer and we found ETV5 was upregulated in ovarian tumor samples compared to ovarian tissue controls. The in vitro inhibition of ETV5 decreased cell proliferation in serum-deprived conditions, induced EMT and cell migration and decreased cell adhesion to extracellular matrix components. ETV5 inhibition also decreased cell–cell adhesion and induced apoptosis in anchorage-independent conditions. Accordingly, upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. Our findings suggest that the overexpression of ETV5 detected in ovarian cancer cells may contribute to ovarian tumor progression through the ability of ETV5 to enhance proliferation of ovarian cancer cells. In addition, upregulation of ETV5 would play a role in ovarian cancer cell dissemination and metastasis into the peritoneal cavity by protecting ovarian cancer cells from apoptosis and by increasing the adhesion of ovarian cancer cells to the peritoneal wall through the regulation of cell adhesion molecules.Fil: Llaurado, Marta. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Abal, Miguel. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Castellví, Josep. Universidad Autónoma de Barcelona. Hospital Vall D; EspañaFil: Cabrera, Silvia. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Gil Moreno, Antonio. Universitat Autònoma de Barcelona; España. Universidad Autónoma de Barcelona. Hospital Vall D; EspañaFil: Pérez Benavente, Asumpció. Universidad Autónoma de Barcelona. Hospital Vall D; EspañaFil: Colás, Eva. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Doll, Andreas. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaFil: Dolcet, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; EspañaFil: Matias Guiu, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; EspañaFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Reventós, Jaume. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; EspañaFil: Ruiz, Anna. Universidad Autonoma de Barcelona. Hospital Vall D; EspañaWiley2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22269Llaurado, Marta; Abal, Miguel; Castellví, Josep; Cabrera, Silvia; Gil Moreno, Antonio; et al.; ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination; Wiley; International Journal Of Cancer. Journal International Du Cancer.; 130; 7; 8-2011; 1532-15430020-71361097-0215CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ijc.26148/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ijc.26148info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:53Zoai:ri.conicet.gov.ar:11336/22269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:53.557CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
title ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
spellingShingle ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
Llaurado, Marta
Ovarian Cancer
Etv5
Epithelial Cadherin
Emt
title_short ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
title_full ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
title_fullStr ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
title_full_unstemmed ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
title_sort ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
dc.creator.none.fl_str_mv Llaurado, Marta
Abal, Miguel
Castellví, Josep
Cabrera, Silvia
Gil Moreno, Antonio
Pérez Benavente, Asumpció
Colás, Eva
Doll, Andreas
Dolcet, Xavier
Matias Guiu, Xavier
Vazquez, Monica Hebe
Reventós, Jaume
Ruiz, Anna
author Llaurado, Marta
author_facet Llaurado, Marta
Abal, Miguel
Castellví, Josep
Cabrera, Silvia
Gil Moreno, Antonio
Pérez Benavente, Asumpció
Colás, Eva
Doll, Andreas
Dolcet, Xavier
Matias Guiu, Xavier
Vazquez, Monica Hebe
Reventós, Jaume
Ruiz, Anna
author_role author
author2 Abal, Miguel
Castellví, Josep
Cabrera, Silvia
Gil Moreno, Antonio
Pérez Benavente, Asumpció
Colás, Eva
Doll, Andreas
Dolcet, Xavier
Matias Guiu, Xavier
Vazquez, Monica Hebe
Reventós, Jaume
Ruiz, Anna
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ovarian Cancer
Etv5
Epithelial Cadherin
Emt
topic Ovarian Cancer
Etv5
Epithelial Cadherin
Emt
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those that control cellular proliferation, differentiation, apoptosis, tissue remodeling, angiogenesis and transformation. ETV5 belongs to the PEA3 subfamily. PEA3 subfamily members are able to activate the transcription of proteases, matrix metalloproteinases and tissue inhibitor of metalloproteases, which is central to both tumor invasion and angiogenesis. Here, we examined the role of the ETV5 transcription factor in epithelial ovarian cancer and we found ETV5 was upregulated in ovarian tumor samples compared to ovarian tissue controls. The in vitro inhibition of ETV5 decreased cell proliferation in serum-deprived conditions, induced EMT and cell migration and decreased cell adhesion to extracellular matrix components. ETV5 inhibition also decreased cell–cell adhesion and induced apoptosis in anchorage-independent conditions. Accordingly, upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. Our findings suggest that the overexpression of ETV5 detected in ovarian cancer cells may contribute to ovarian tumor progression through the ability of ETV5 to enhance proliferation of ovarian cancer cells. In addition, upregulation of ETV5 would play a role in ovarian cancer cell dissemination and metastasis into the peritoneal cavity by protecting ovarian cancer cells from apoptosis and by increasing the adhesion of ovarian cancer cells to the peritoneal wall through the regulation of cell adhesion molecules.
Fil: Llaurado, Marta. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Abal, Miguel. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Castellví, Josep. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Cabrera, Silvia. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Gil Moreno, Antonio. Universitat Autònoma de Barcelona; España. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Pérez Benavente, Asumpció. Universidad Autónoma de Barcelona. Hospital Vall D; España
Fil: Colás, Eva. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Doll, Andreas. Universidad Autonoma de Barcelona. Hospital Vall D; España
Fil: Dolcet, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; España
Fil: Matias Guiu, Xavier. Universidad de Lleida. Instituto de Recerca Biomédica.; España
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Reventós, Jaume. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
Fil: Ruiz, Anna. Universidad Autonoma de Barcelona. Hospital Vall D; España
description Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those that control cellular proliferation, differentiation, apoptosis, tissue remodeling, angiogenesis and transformation. ETV5 belongs to the PEA3 subfamily. PEA3 subfamily members are able to activate the transcription of proteases, matrix metalloproteinases and tissue inhibitor of metalloproteases, which is central to both tumor invasion and angiogenesis. Here, we examined the role of the ETV5 transcription factor in epithelial ovarian cancer and we found ETV5 was upregulated in ovarian tumor samples compared to ovarian tissue controls. The in vitro inhibition of ETV5 decreased cell proliferation in serum-deprived conditions, induced EMT and cell migration and decreased cell adhesion to extracellular matrix components. ETV5 inhibition also decreased cell–cell adhesion and induced apoptosis in anchorage-independent conditions. Accordingly, upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. Our findings suggest that the overexpression of ETV5 detected in ovarian cancer cells may contribute to ovarian tumor progression through the ability of ETV5 to enhance proliferation of ovarian cancer cells. In addition, upregulation of ETV5 would play a role in ovarian cancer cell dissemination and metastasis into the peritoneal cavity by protecting ovarian cancer cells from apoptosis and by increasing the adhesion of ovarian cancer cells to the peritoneal wall through the regulation of cell adhesion molecules.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22269
Llaurado, Marta; Abal, Miguel; Castellví, Josep; Cabrera, Silvia; Gil Moreno, Antonio; et al.; ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination; Wiley; International Journal Of Cancer. Journal International Du Cancer.; 130; 7; 8-2011; 1532-1543
0020-7136
1097-0215
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22269
identifier_str_mv Llaurado, Marta; Abal, Miguel; Castellví, Josep; Cabrera, Silvia; Gil Moreno, Antonio; et al.; ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination; Wiley; International Journal Of Cancer. Journal International Du Cancer.; 130; 7; 8-2011; 1532-1543
0020-7136
1097-0215
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ijc.26148/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/ijc.26148
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269548531679232
score 13.13397

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