Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions

Autores
Sierra, Liliana Beatríz; Roco, Julieta; Alarcón, Gabriela del Jesús; Medina, Mirta; Van Nieuwenhove, Carina Paola; Peral, Maria de Los Angeles; Jerez, Susana Josefina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD) or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased intima/media ratio. Including chia oil in the HD partially normalized the response to Ach and the intima/media ratio, and totally restored the NO-release. In addition, dietary supplementation with chia oil blunted the contractile response to angiotensin II and noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil could improve vascular function under hypercholesterolaemic conditions and therefore could serve as a true functional food.
Fil: Sierra, Liliana Beatríz. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Roco, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Alarcón, Gabriela del Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Medina, Mirta. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Van Nieuwenhove, Carina Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Medicina; Argentina
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Materia
Chia Oil
Hypercholesterolaemia
Vascular Dysfunction
Noradrenaline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28727
Acceder
id CONICETDig_732f19770034e218bb71534f0c65f8f2
oai_identifier_str oai:ri.conicet.gov.ar:11336/28727
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditionsSierra, Liliana BeatrízRoco, JulietaAlarcón, Gabriela del JesúsMedina, MirtaVan Nieuwenhove, Carina PaolaPeral, Maria de Los AngelesJerez, Susana JosefinaChia OilHypercholesterolaemiaVascular DysfunctionNoradrenalinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD) or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased intima/media ratio. Including chia oil in the HD partially normalized the response to Ach and the intima/media ratio, and totally restored the NO-release. In addition, dietary supplementation with chia oil blunted the contractile response to angiotensin II and noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil could improve vascular function under hypercholesterolaemic conditions and therefore could serve as a true functional food.Fil: Sierra, Liliana Beatríz. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Roco, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Alarcón, Gabriela del Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Medina, Mirta. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Van Nieuwenhove, Carina Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Medicina; ArgentinaFil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaElsevier2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28727Sierra, Liliana Beatríz; Roco, Julieta; Alarcón, Gabriela del Jesús; Medina, Mirta; Van Nieuwenhove, Carina Paola; et al.; Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions; Elsevier; Journal of Functional Foods; 14; 4-2015; 641-6491756-46462214-9414CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2015.02.042info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1756464615001048info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:05Zoai:ri.conicet.gov.ar:11336/28727instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:05.588CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
title Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
spellingShingle Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
Sierra, Liliana Beatríz
Chia Oil
Hypercholesterolaemia
Vascular Dysfunction
Noradrenaline
title_short Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
title_full Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
title_fullStr Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
title_full_unstemmed Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
title_sort Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions
dc.creator.none.fl_str_mv Sierra, Liliana Beatríz
Roco, Julieta
Alarcón, Gabriela del Jesús
Medina, Mirta
Van Nieuwenhove, Carina Paola
Peral, Maria de Los Angeles
Jerez, Susana Josefina
author Sierra, Liliana Beatríz
author_facet Sierra, Liliana Beatríz
Roco, Julieta
Alarcón, Gabriela del Jesús
Medina, Mirta
Van Nieuwenhove, Carina Paola
Peral, Maria de Los Angeles
Jerez, Susana Josefina
author_role author
author2 Roco, Julieta
Alarcón, Gabriela del Jesús
Medina, Mirta
Van Nieuwenhove, Carina Paola
Peral, Maria de Los Angeles
Jerez, Susana Josefina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chia Oil
Hypercholesterolaemia
Vascular Dysfunction
Noradrenaline
topic Chia Oil
Hypercholesterolaemia
Vascular Dysfunction
Noradrenaline
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD) or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased intima/media ratio. Including chia oil in the HD partially normalized the response to Ach and the intima/media ratio, and totally restored the NO-release. In addition, dietary supplementation with chia oil blunted the contractile response to angiotensin II and noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil could improve vascular function under hypercholesterolaemic conditions and therefore could serve as a true functional food.
Fil: Sierra, Liliana Beatríz. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Roco, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Alarcón, Gabriela del Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Medina, Mirta. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Van Nieuwenhove, Carina Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Medicina; Argentina
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
description The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD) or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased intima/media ratio. Including chia oil in the HD partially normalized the response to Ach and the intima/media ratio, and totally restored the NO-release. In addition, dietary supplementation with chia oil blunted the contractile response to angiotensin II and noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil could improve vascular function under hypercholesterolaemic conditions and therefore could serve as a true functional food.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28727
Sierra, Liliana Beatríz; Roco, Julieta; Alarcón, Gabriela del Jesús; Medina, Mirta; Van Nieuwenhove, Carina Paola; et al.; Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions; Elsevier; Journal of Functional Foods; 14; 4-2015; 641-649
1756-4646
2214-9414
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28727
identifier_str_mv Sierra, Liliana Beatríz; Roco, Julieta; Alarcón, Gabriela del Jesús; Medina, Mirta; Van Nieuwenhove, Carina Paola; et al.; Dietary intervention with salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions; Elsevier; Journal of Functional Foods; 14; 4-2015; 641-649
1756-4646
2214-9414
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2015.02.042
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1756464615001048
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613521430544384
score 13.070432

Publicaciones similares