The X-linked inhibitor of apoptosis regulates long-term depression and learning rate

Autores
Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; Johnstone, Aaron; Nader, Karim; Séguéla, Philippe; Barker, Philip A.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
Fil: Gibon, Julien. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Gamache, Karine. McGill University; Canadá
Fil: Thomas, Rhalena A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: De Leon, Andres. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Johnstone, Aaron. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Nader, Karim. McGill University; Canadá
Fil: Séguéla, Philippe. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Barker, Philip A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Materia
Ampar
Caspase-3
Hippocampus
Synaptic Activity
Xiap
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/76265
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/76265
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The X-linked inhibitor of apoptosis regulates long-term depression and learning rateGibon, JulienUnsain, NicolasGamache, KarineThomas, Rhalena A.De Leon, AndresJohnstone, AaronNader, KarimSéguéla, PhilippeBarker, Philip A.AmparCaspase-3HippocampusSynaptic ActivityXiaphttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.Fil: Gibon, Julien. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Gamache, Karine. McGill University; CanadáFil: Thomas, Rhalena A.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: De Leon, Andres. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Johnstone, Aaron. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Nader, Karim. McGill University; CanadáFil: Séguéla, Philippe. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Barker, Philip A.. McGill University. Montreal Neurological Institute and Hospital; CanadáFederation of American Societies for Experimental Biology2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/76265Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; et al.; The X-linked inhibitor of apoptosis regulates long-term depression and learning rate; Federation of American Societies for Experimental Biology; FASEB Journal; 30; 9; 9-2016; 3083-30900892-66381530-6860CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1096/fj.201600384Rinfo:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/10.1096/fj.201600384Rinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:55Zoai:ri.conicet.gov.ar:11336/76265instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:55.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
title The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
spellingShingle The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
Gibon, Julien
Ampar
Caspase-3
Hippocampus
Synaptic Activity
Xiap
title_short The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
title_full The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
title_fullStr The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
title_full_unstemmed The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
title_sort The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
dc.creator.none.fl_str_mv Gibon, Julien
Unsain, Nicolas
Gamache, Karine
Thomas, Rhalena A.
De Leon, Andres
Johnstone, Aaron
Nader, Karim
Séguéla, Philippe
Barker, Philip A.
author Gibon, Julien
author_facet Gibon, Julien
Unsain, Nicolas
Gamache, Karine
Thomas, Rhalena A.
De Leon, Andres
Johnstone, Aaron
Nader, Karim
Séguéla, Philippe
Barker, Philip A.
author_role author
author2 Unsain, Nicolas
Gamache, Karine
Thomas, Rhalena A.
De Leon, Andres
Johnstone, Aaron
Nader, Karim
Séguéla, Philippe
Barker, Philip A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ampar
Caspase-3
Hippocampus
Synaptic Activity
Xiap
topic Ampar
Caspase-3
Hippocampus
Synaptic Activity
Xiap
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
Fil: Gibon, Julien. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Gamache, Karine. McGill University; Canadá
Fil: Thomas, Rhalena A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: De Leon, Andres. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Johnstone, Aaron. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Nader, Karim. McGill University; Canadá
Fil: Séguéla, Philippe. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Barker, Philip A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
description Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/76265
Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; et al.; The X-linked inhibitor of apoptosis regulates long-term depression and learning rate; Federation of American Societies for Experimental Biology; FASEB Journal; 30; 9; 9-2016; 3083-3090
0892-6638
1530-6860
CONICET Digital
CONICET
url http://hdl.handle.net/11336/76265
identifier_str_mv Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; et al.; The X-linked inhibitor of apoptosis regulates long-term depression and learning rate; Federation of American Societies for Experimental Biology; FASEB Journal; 30; 9; 9-2016; 3083-3090
0892-6638
1530-6860
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1096/fj.201600384R
info:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/10.1096/fj.201600384R
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082631692713984
score 12.891075

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