Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease

Autores
Cardoso, Estela M.del Lujan; Contreras, Liliana; Tumilasci, Elida G.; Elbert, Alicia; Aguirre, Elvira C.; Aquilano, Daniel R.; Arregger, Alejandro Luis
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Hypogonadism is frequent in patients with end-stage renal disease (ESRD). Salivary testosterone (Sal-T) is a non-invasive tool to screen androgen deficiency in adult male with normal renal function. However, available data on its utility in ESRD are not conclusive. OBJECTIVES: The objectives of the study were: (i) to compare free testosterone fractions in saliva (SAL-T) and serum (Free-T); (ii) to establish the correlation of Sal-T with circulating total (TT) and bioavailable testosterone (Bio-T); (iii) to detect androgen deficiency through SalT; (iv) to determine the correlation of Sal-T with clinical parameters. METHODS: The study included: 60 adult ESRD men on haemodialysis (20–60 years old) with decreased libido referred from two dialysis centres; 112 eugonadic and 40 hypogonadic adult men with normal renal function as controls. Simultaneous morning saliva and serum samples were obtained for testosterone measurements by liquid RIA (SAL-T; TT). Free-T and Bio-T were calculated by the Vermeulen equation. RESULTS: Sal-T (0.338 ± 0.177 nM) and Free-T (0.338 ± 0.165 nM) did not differ (P > 0.900) in ESRD as well as in control (0.337 ± 0.182 and 0.337 ± 0.172 nM, respectively; P > 0.900). Sal-T levels correlated positively (P < 0.0001) with Free-T (r = 0.95), TT (r = 0.80) and Bio-T (r = 0.76) in ESRD. Sal-T negatively correlated with age and years on dialytic therapy. Sal-T showed 100% sensitivity and specificity to differentiate patients with androgen deficiency (22%) from those with normal androgen levels (78%). Hypogonadism was hypergonadotrophic in 69% cases and hypogonadotrophic in 31%. CONCLUSIONS: These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.
Fil: Cardoso, Estela M.del Lujan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Contreras, Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Tumilasci, Elida G.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Elbert, Alicia. Centro de Estudios Renales e Hipertención Arterial; Argentina
Fil: Aguirre, Elvira C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Aquilano, Daniel R.. Instituto de Análisis Bioquímicos de Endodrinología; Argentina
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
End Stage Renal Disease
Male Androgen Deficiency
Haemodialysis
Salivary Testosterone
Serum Testosterone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15131
Acceder
id CONICETDig_722b0d64665280a0d5e6a8d0480b77f1
oai_identifier_str oai:ri.conicet.gov.ar:11336/15131
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal diseaseCardoso, Estela M.del LujanContreras, LilianaTumilasci, Elida G.Elbert, AliciaAguirre, Elvira C.Aquilano, Daniel R.Arregger, Alejandro LuisEnd Stage Renal DiseaseMale Androgen DeficiencyHaemodialysisSalivary TestosteroneSerum Testosteronehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND: Hypogonadism is frequent in patients with end-stage renal disease (ESRD). Salivary testosterone (Sal-T) is a non-invasive tool to screen androgen deficiency in adult male with normal renal function. However, available data on its utility in ESRD are not conclusive. OBJECTIVES: The objectives of the study were: (i) to compare free testosterone fractions in saliva (SAL-T) and serum (Free-T); (ii) to establish the correlation of Sal-T with circulating total (TT) and bioavailable testosterone (Bio-T); (iii) to detect androgen deficiency through SalT; (iv) to determine the correlation of Sal-T with clinical parameters. METHODS: The study included: 60 adult ESRD men on haemodialysis (20–60 years old) with decreased libido referred from two dialysis centres; 112 eugonadic and 40 hypogonadic adult men with normal renal function as controls. Simultaneous morning saliva and serum samples were obtained for testosterone measurements by liquid RIA (SAL-T; TT). Free-T and Bio-T were calculated by the Vermeulen equation. RESULTS: Sal-T (0.338 ± 0.177 nM) and Free-T (0.338 ± 0.165 nM) did not differ (P > 0.900) in ESRD as well as in control (0.337 ± 0.182 and 0.337 ± 0.172 nM, respectively; P > 0.900). Sal-T levels correlated positively (P < 0.0001) with Free-T (r = 0.95), TT (r = 0.80) and Bio-T (r = 0.76) in ESRD. Sal-T negatively correlated with age and years on dialytic therapy. Sal-T showed 100% sensitivity and specificity to differentiate patients with androgen deficiency (22%) from those with normal androgen levels (78%). Hypogonadism was hypergonadotrophic in 69% cases and hypogonadotrophic in 31%. CONCLUSIONS: These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.Fil: Cardoso, Estela M.del Lujan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Contreras, Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Tumilasci, Elida G.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Elbert, Alicia. Centro de Estudios Renales e Hipertención Arterial; ArgentinaFil: Aguirre, Elvira C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Aquilano, Daniel R.. Instituto de Análisis Bioquímicos de Endodrinología; ArgentinaFil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaOxford University Press2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15131Cardoso, Estela M.del Lujan; Contreras, Liliana; Tumilasci, Elida G.; Elbert, Alicia; Aguirre, Elvira C.; et al.; Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease; Oxford University Press; Nephrology Dialysis Transplantation; 26; 2; 7-2011; 667-6830931-0509enginfo:eu-repo/semantics/altIdentifier/doi/10.1093/ndt/gfq439info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfq439info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:27Zoai:ri.conicet.gov.ar:11336/15131instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:28.014CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
title Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
spellingShingle Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
Cardoso, Estela M.del Lujan
End Stage Renal Disease
Male Androgen Deficiency
Haemodialysis
Salivary Testosterone
Serum Testosterone
title_short Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
title_full Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
title_fullStr Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
title_full_unstemmed Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
title_sort Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
dc.creator.none.fl_str_mv Cardoso, Estela M.del Lujan
Contreras, Liliana
Tumilasci, Elida G.
Elbert, Alicia
Aguirre, Elvira C.
Aquilano, Daniel R.
Arregger, Alejandro Luis
author Cardoso, Estela M.del Lujan
author_facet Cardoso, Estela M.del Lujan
Contreras, Liliana
Tumilasci, Elida G.
Elbert, Alicia
Aguirre, Elvira C.
Aquilano, Daniel R.
Arregger, Alejandro Luis
author_role author
author2 Contreras, Liliana
Tumilasci, Elida G.
Elbert, Alicia
Aguirre, Elvira C.
Aquilano, Daniel R.
Arregger, Alejandro Luis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv End Stage Renal Disease
Male Androgen Deficiency
Haemodialysis
Salivary Testosterone
Serum Testosterone
topic End Stage Renal Disease
Male Androgen Deficiency
Haemodialysis
Salivary Testosterone
Serum Testosterone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Hypogonadism is frequent in patients with end-stage renal disease (ESRD). Salivary testosterone (Sal-T) is a non-invasive tool to screen androgen deficiency in adult male with normal renal function. However, available data on its utility in ESRD are not conclusive. OBJECTIVES: The objectives of the study were: (i) to compare free testosterone fractions in saliva (SAL-T) and serum (Free-T); (ii) to establish the correlation of Sal-T with circulating total (TT) and bioavailable testosterone (Bio-T); (iii) to detect androgen deficiency through SalT; (iv) to determine the correlation of Sal-T with clinical parameters. METHODS: The study included: 60 adult ESRD men on haemodialysis (20–60 years old) with decreased libido referred from two dialysis centres; 112 eugonadic and 40 hypogonadic adult men with normal renal function as controls. Simultaneous morning saliva and serum samples were obtained for testosterone measurements by liquid RIA (SAL-T; TT). Free-T and Bio-T were calculated by the Vermeulen equation. RESULTS: Sal-T (0.338 ± 0.177 nM) and Free-T (0.338 ± 0.165 nM) did not differ (P > 0.900) in ESRD as well as in control (0.337 ± 0.182 and 0.337 ± 0.172 nM, respectively; P > 0.900). Sal-T levels correlated positively (P < 0.0001) with Free-T (r = 0.95), TT (r = 0.80) and Bio-T (r = 0.76) in ESRD. Sal-T negatively correlated with age and years on dialytic therapy. Sal-T showed 100% sensitivity and specificity to differentiate patients with androgen deficiency (22%) from those with normal androgen levels (78%). Hypogonadism was hypergonadotrophic in 69% cases and hypogonadotrophic in 31%. CONCLUSIONS: These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.
Fil: Cardoso, Estela M.del Lujan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Contreras, Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Tumilasci, Elida G.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Elbert, Alicia. Centro de Estudios Renales e Hipertención Arterial; Argentina
Fil: Aguirre, Elvira C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Aquilano, Daniel R.. Instituto de Análisis Bioquímicos de Endodrinología; Argentina
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description BACKGROUND: Hypogonadism is frequent in patients with end-stage renal disease (ESRD). Salivary testosterone (Sal-T) is a non-invasive tool to screen androgen deficiency in adult male with normal renal function. However, available data on its utility in ESRD are not conclusive. OBJECTIVES: The objectives of the study were: (i) to compare free testosterone fractions in saliva (SAL-T) and serum (Free-T); (ii) to establish the correlation of Sal-T with circulating total (TT) and bioavailable testosterone (Bio-T); (iii) to detect androgen deficiency through SalT; (iv) to determine the correlation of Sal-T with clinical parameters. METHODS: The study included: 60 adult ESRD men on haemodialysis (20–60 years old) with decreased libido referred from two dialysis centres; 112 eugonadic and 40 hypogonadic adult men with normal renal function as controls. Simultaneous morning saliva and serum samples were obtained for testosterone measurements by liquid RIA (SAL-T; TT). Free-T and Bio-T were calculated by the Vermeulen equation. RESULTS: Sal-T (0.338 ± 0.177 nM) and Free-T (0.338 ± 0.165 nM) did not differ (P > 0.900) in ESRD as well as in control (0.337 ± 0.182 and 0.337 ± 0.172 nM, respectively; P > 0.900). Sal-T levels correlated positively (P < 0.0001) with Free-T (r = 0.95), TT (r = 0.80) and Bio-T (r = 0.76) in ESRD. Sal-T negatively correlated with age and years on dialytic therapy. Sal-T showed 100% sensitivity and specificity to differentiate patients with androgen deficiency (22%) from those with normal androgen levels (78%). Hypogonadism was hypergonadotrophic in 69% cases and hypogonadotrophic in 31%. CONCLUSIONS: These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15131
Cardoso, Estela M.del Lujan; Contreras, Liliana; Tumilasci, Elida G.; Elbert, Alicia; Aguirre, Elvira C.; et al.; Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease; Oxford University Press; Nephrology Dialysis Transplantation; 26; 2; 7-2011; 667-683
0931-0509
url http://hdl.handle.net/11336/15131
identifier_str_mv Cardoso, Estela M.del Lujan; Contreras, Liliana; Tumilasci, Elida G.; Elbert, Alicia; Aguirre, Elvira C.; et al.; Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease; Oxford University Press; Nephrology Dialysis Transplantation; 26; 2; 7-2011; 667-683
0931-0509
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/ndt/gfq439
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfq439
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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