The dual face of central nervous system tuberculosis: a new Janus Bifrons?

Autores
Saenz, Brenda; Hernandez Pando, Rogelio; Fragoso, Gladis; Bottasso, Oscar Adelmo; Cardenas, Graciela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tuberculosis (TB) is still a common infectious disease in developing countries, but it is also re-emerging in industrialized nations due to the HIV/AIDS pandemic. In addition to bacillary virulence, the host immune response plays a major role in the development of an active disease (either as a primary infection or reactivation) and in controlling the infection. Even though several mechanisms are involved in regulating the human immune response, biological environment seems to be determinant. In this context, the integrated neuro-immune-endocrine system strongly influences TB clinical outcome. One of the most important clinical aspects of TB is shown when the infection locates in the central nervous system (CNS), in which a very different set of immune responses is induced. Herein we review several aspects of the paradoxical immune response triggered during CNS-TB infection, and discuss the implications of this response in the cerebral infection outcome.
Fil: Saenz, Brenda. Universidad Nacional Autónoma de México; México
Fil: Hernandez Pando, Rogelio. Instituto Nacional de Ciencias Médicas y de la Nutrición; México
Fil: Fragoso, Gladis. Universidad Nacional Autónoma de México; México
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; México
Materia
Tuberculosis
Neurological Compromise
Regulation
Immune Response
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15337
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The dual face of central nervous system tuberculosis: a new Janus Bifrons?Saenz, BrendaHernandez Pando, RogelioFragoso, GladisBottasso, Oscar AdelmoCardenas, GracielaTuberculosisNeurological CompromiseRegulationImmune Responsehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Tuberculosis (TB) is still a common infectious disease in developing countries, but it is also re-emerging in industrialized nations due to the HIV/AIDS pandemic. In addition to bacillary virulence, the host immune response plays a major role in the development of an active disease (either as a primary infection or reactivation) and in controlling the infection. Even though several mechanisms are involved in regulating the human immune response, biological environment seems to be determinant. In this context, the integrated neuro-immune-endocrine system strongly influences TB clinical outcome. One of the most important clinical aspects of TB is shown when the infection locates in the central nervous system (CNS), in which a very different set of immune responses is induced. Herein we review several aspects of the paradoxical immune response triggered during CNS-TB infection, and discuss the implications of this response in the cerebral infection outcome.Fil: Saenz, Brenda. Universidad Nacional Autónoma de México; MéxicoFil: Hernandez Pando, Rogelio. Instituto Nacional de Ciencias Médicas y de la Nutrición; MéxicoFil: Fragoso, Gladis. Universidad Nacional Autónoma de México; MéxicoFil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; MéxicoElsevier2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15337Saenz, Brenda; Hernandez Pando, Rogelio; Fragoso, Gladis; Bottasso, Oscar Adelmo; Cardenas, Graciela; The dual face of central nervous system tuberculosis: a new Janus Bifrons?; Elsevier; Tuberculosis (edinb); 93; 2; 3-2013; 130-1351472-9792enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.tube.2012.11.011info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472979212002119info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:23:33Zoai:ri.conicet.gov.ar:11336/15337instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:23:33.819CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The dual face of central nervous system tuberculosis: a new Janus Bifrons?
title The dual face of central nervous system tuberculosis: a new Janus Bifrons?
spellingShingle The dual face of central nervous system tuberculosis: a new Janus Bifrons?
Saenz, Brenda
Tuberculosis
Neurological Compromise
Regulation
Immune Response
title_short The dual face of central nervous system tuberculosis: a new Janus Bifrons?
title_full The dual face of central nervous system tuberculosis: a new Janus Bifrons?
title_fullStr The dual face of central nervous system tuberculosis: a new Janus Bifrons?
title_full_unstemmed The dual face of central nervous system tuberculosis: a new Janus Bifrons?
title_sort The dual face of central nervous system tuberculosis: a new Janus Bifrons?
dc.creator.none.fl_str_mv Saenz, Brenda
Hernandez Pando, Rogelio
Fragoso, Gladis
Bottasso, Oscar Adelmo
Cardenas, Graciela
author Saenz, Brenda
author_facet Saenz, Brenda
Hernandez Pando, Rogelio
Fragoso, Gladis
Bottasso, Oscar Adelmo
Cardenas, Graciela
author_role author
author2 Hernandez Pando, Rogelio
Fragoso, Gladis
Bottasso, Oscar Adelmo
Cardenas, Graciela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Tuberculosis
Neurological Compromise
Regulation
Immune Response
topic Tuberculosis
Neurological Compromise
Regulation
Immune Response
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tuberculosis (TB) is still a common infectious disease in developing countries, but it is also re-emerging in industrialized nations due to the HIV/AIDS pandemic. In addition to bacillary virulence, the host immune response plays a major role in the development of an active disease (either as a primary infection or reactivation) and in controlling the infection. Even though several mechanisms are involved in regulating the human immune response, biological environment seems to be determinant. In this context, the integrated neuro-immune-endocrine system strongly influences TB clinical outcome. One of the most important clinical aspects of TB is shown when the infection locates in the central nervous system (CNS), in which a very different set of immune responses is induced. Herein we review several aspects of the paradoxical immune response triggered during CNS-TB infection, and discuss the implications of this response in the cerebral infection outcome.
Fil: Saenz, Brenda. Universidad Nacional Autónoma de México; México
Fil: Hernandez Pando, Rogelio. Instituto Nacional de Ciencias Médicas y de la Nutrición; México
Fil: Fragoso, Gladis. Universidad Nacional Autónoma de México; México
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardenas, Graciela. Instituto Nacional de Neurología y Neurocirugía; México
description Tuberculosis (TB) is still a common infectious disease in developing countries, but it is also re-emerging in industrialized nations due to the HIV/AIDS pandemic. In addition to bacillary virulence, the host immune response plays a major role in the development of an active disease (either as a primary infection or reactivation) and in controlling the infection. Even though several mechanisms are involved in regulating the human immune response, biological environment seems to be determinant. In this context, the integrated neuro-immune-endocrine system strongly influences TB clinical outcome. One of the most important clinical aspects of TB is shown when the infection locates in the central nervous system (CNS), in which a very different set of immune responses is induced. Herein we review several aspects of the paradoxical immune response triggered during CNS-TB infection, and discuss the implications of this response in the cerebral infection outcome.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15337
Saenz, Brenda; Hernandez Pando, Rogelio; Fragoso, Gladis; Bottasso, Oscar Adelmo; Cardenas, Graciela; The dual face of central nervous system tuberculosis: a new Janus Bifrons?; Elsevier; Tuberculosis (edinb); 93; 2; 3-2013; 130-135
1472-9792
url http://hdl.handle.net/11336/15337
identifier_str_mv Saenz, Brenda; Hernandez Pando, Rogelio; Fragoso, Gladis; Bottasso, Oscar Adelmo; Cardenas, Graciela; The dual face of central nervous system tuberculosis: a new Janus Bifrons?; Elsevier; Tuberculosis (edinb); 93; 2; 3-2013; 130-135
1472-9792
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tube.2012.11.011
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472979212002119
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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