Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes

Autores
Bozzini, Clarisa; Champin, Graciela Monica; Alippi, Rosa Maria; Bozzini, Carlos Eduardo Jose
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Biomechanical behavior of bone is related to the amount (bone mass) and its architectural distribution, as well as the mechanical quality of bone material. This investigation reports the effects of exposure to different simulated high altitudes (SHA) (1850, 2900, 4100, and 5450 m) on femur biomechanical properties in female growing rats exposed to SHA (22-23 h/d) between the 32° and the 74° days of life. The ex vivo right femur was mechanically tested in three-point bending. The left femur was ashed at 600°C and the ash weight obtained. Final body weight and structural (loads at yielding and fracture, stiffness, and elastic energy absorption) and architectural (diaphyseal cross-sectional area, cortical area, and cross-sectional moment of inertia) were negatively affected in the animals exposed to the two highest SHA. Material properties of the mineralized tissue (Young's modulus and limit elastic stress) and the degree of mineralization were unaffected. In conclusion, hypoxic bone is weaker than normoxic one because of its smaller bone mass, which appear to have been negatively influenced by SHA in relation to its effects on overall body mass.
Fil: Bozzini, Clarisa. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Champin, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
Fil: Alippi, Rosa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
Fil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
Materia
Hiigh Altitud
Biomechanics
Growth
Bone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2019
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/2019
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudesBozzini, ClarisaChampin, Graciela MonicaAlippi, Rosa MariaBozzini, Carlos Eduardo JoseHiigh AltitudBiomechanicsGrowthBonehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Biomechanical behavior of bone is related to the amount (bone mass) and its architectural distribution, as well as the mechanical quality of bone material. This investigation reports the effects of exposure to different simulated high altitudes (SHA) (1850, 2900, 4100, and 5450 m) on femur biomechanical properties in female growing rats exposed to SHA (22-23 h/d) between the 32° and the 74° days of life. The ex vivo right femur was mechanically tested in three-point bending. The left femur was ashed at 600°C and the ash weight obtained. Final body weight and structural (loads at yielding and fracture, stiffness, and elastic energy absorption) and architectural (diaphyseal cross-sectional area, cortical area, and cross-sectional moment of inertia) were negatively affected in the animals exposed to the two highest SHA. Material properties of the mineralized tissue (Young's modulus and limit elastic stress) and the degree of mineralization were unaffected. In conclusion, hypoxic bone is weaker than normoxic one because of its smaller bone mass, which appear to have been negatively influenced by SHA in relation to its effects on overall body mass.Fil: Bozzini, Clarisa. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Champin, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; ArgentinaFil: Alippi, Rosa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; ArgentinaFil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; ArgentinaMary Ann Liebert Inc2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdftext/plainapplication/pdfhttp://hdl.handle.net/11336/2019Bozzini, Clarisa; Champin, Graciela Monica; Alippi, Rosa Maria; Bozzini, Carlos Eduardo Jose; Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes; Mary Ann Liebert Inc; High Altitude Medicine & Biology; 14; 4; 8-2013; 367-3741527-0297enginfo:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/epub/10.1089/ham.2013.1038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:16Zoai:ri.conicet.gov.ar:11336/2019instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:16.786CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
title Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
spellingShingle Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
Bozzini, Clarisa
Hiigh Altitud
Biomechanics
Growth
Bone
title_short Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
title_full Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
title_fullStr Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
title_full_unstemmed Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
title_sort Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes
dc.creator.none.fl_str_mv Bozzini, Clarisa
Champin, Graciela Monica
Alippi, Rosa Maria
Bozzini, Carlos Eduardo Jose
author Bozzini, Clarisa
author_facet Bozzini, Clarisa
Champin, Graciela Monica
Alippi, Rosa Maria
Bozzini, Carlos Eduardo Jose
author_role author
author2 Champin, Graciela Monica
Alippi, Rosa Maria
Bozzini, Carlos Eduardo Jose
author2_role author
author
author
dc.subject.none.fl_str_mv Hiigh Altitud
Biomechanics
Growth
Bone
topic Hiigh Altitud
Biomechanics
Growth
Bone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Biomechanical behavior of bone is related to the amount (bone mass) and its architectural distribution, as well as the mechanical quality of bone material. This investigation reports the effects of exposure to different simulated high altitudes (SHA) (1850, 2900, 4100, and 5450 m) on femur biomechanical properties in female growing rats exposed to SHA (22-23 h/d) between the 32° and the 74° days of life. The ex vivo right femur was mechanically tested in three-point bending. The left femur was ashed at 600°C and the ash weight obtained. Final body weight and structural (loads at yielding and fracture, stiffness, and elastic energy absorption) and architectural (diaphyseal cross-sectional area, cortical area, and cross-sectional moment of inertia) were negatively affected in the animals exposed to the two highest SHA. Material properties of the mineralized tissue (Young's modulus and limit elastic stress) and the degree of mineralization were unaffected. In conclusion, hypoxic bone is weaker than normoxic one because of its smaller bone mass, which appear to have been negatively influenced by SHA in relation to its effects on overall body mass.
Fil: Bozzini, Clarisa. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Champin, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
Fil: Alippi, Rosa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
Fil: Bozzini, Carlos Eduardo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad de Buenos Aires; Argentina
description Biomechanical behavior of bone is related to the amount (bone mass) and its architectural distribution, as well as the mechanical quality of bone material. This investigation reports the effects of exposure to different simulated high altitudes (SHA) (1850, 2900, 4100, and 5450 m) on femur biomechanical properties in female growing rats exposed to SHA (22-23 h/d) between the 32° and the 74° days of life. The ex vivo right femur was mechanically tested in three-point bending. The left femur was ashed at 600°C and the ash weight obtained. Final body weight and structural (loads at yielding and fracture, stiffness, and elastic energy absorption) and architectural (diaphyseal cross-sectional area, cortical area, and cross-sectional moment of inertia) were negatively affected in the animals exposed to the two highest SHA. Material properties of the mineralized tissue (Young's modulus and limit elastic stress) and the degree of mineralization were unaffected. In conclusion, hypoxic bone is weaker than normoxic one because of its smaller bone mass, which appear to have been negatively influenced by SHA in relation to its effects on overall body mass.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2019
Bozzini, Clarisa; Champin, Graciela Monica; Alippi, Rosa Maria; Bozzini, Carlos Eduardo Jose; Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes; Mary Ann Liebert Inc; High Altitude Medicine & Biology; 14; 4; 8-2013; 367-374
1527-0297
url http://hdl.handle.net/11336/2019
identifier_str_mv Bozzini, Clarisa; Champin, Graciela Monica; Alippi, Rosa Maria; Bozzini, Carlos Eduardo Jose; Static Biomechanics in bone from growing rats exposed chronically to simulated high altitudes; Mary Ann Liebert Inc; High Altitude Medicine & Biology; 14; 4; 8-2013; 367-374
1527-0297
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/epub/10.1089/ham.2013.1038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
text/plain
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert Inc
publisher.none.fl_str_mv Mary Ann Liebert Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269792537411584
score 13.13397

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