Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?

Autores
Rey, Estela Beatriz; Perez Lana, María Belén; Galluzzo, Liliana; Blanco, Georgina; Onetto, Claudia; Straminsky, Vanesa; Nolting, Manuel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1ß and the hormonal and metabolic alterations in women with polycystic ovary sindrome (PCO). Materials and Methods: Case-control study. CRP, IL-6 and IL-1beta were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control. Results: The average CRP values was 5.1 in the cases vs 0.8 mg/l in control group (P minor 0.0001). The IL-6 average values were 2.77 in the cases vs 2.70 pg/ml in the control group (p=0.254). IL-1beta levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (P minor 0.0001) as well as with the presence of obesity (P minor 0.02). No correlation was found between PCR and hyperandrogenemia (p=0.4) nor between IL-6 values and IR (P =0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (P=0.2). A significant correlation was found between IL-6 levels and obesity (P minor 0.0001). Conclusions: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to insulin resistance.
Fil: Rey, Estela Beatriz. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Perez Lana, María Belén. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Galluzzo, Liliana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Blanco, Georgina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Onetto, Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Straminsky, Vanesa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Nolting, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Polycystic Ovary Sindrome
C-Reactive Protein
Cytokines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8060
Acceder
id CONICETDig_71cb8d2eecc7c81741923aabef0d7877
oai_identifier_str oai:ri.conicet.gov.ar:11336/8060
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?Rey, Estela BeatrizPerez Lana, María BelénGalluzzo, LilianaBlanco, GeorginaOnetto, ClaudiaStraminsky, VanesaNolting, ManuelPolycystic Ovary SindromeC-Reactive ProteinCytokineshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aims: To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1ß and the hormonal and metabolic alterations in women with polycystic ovary sindrome (PCO). Materials and Methods: Case-control study. CRP, IL-6 and IL-1beta were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control. Results: The average CRP values was 5.1 in the cases vs 0.8 mg/l in control group (P minor 0.0001). The IL-6 average values were 2.77 in the cases vs 2.70 pg/ml in the control group (p=0.254). IL-1beta levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (P minor 0.0001) as well as with the presence of obesity (P minor 0.02). No correlation was found between PCR and hyperandrogenemia (p=0.4) nor between IL-6 values and IR (P =0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (P=0.2). A significant correlation was found between IL-6 levels and obesity (P minor 0.0001). Conclusions: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to insulin resistance.Fil: Rey, Estela Beatriz. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; ArgentinaFil: Perez Lana, María Belén. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Galluzzo, Liliana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Blanco, Georgina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Onetto, Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Straminsky, Vanesa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Nolting, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaInforma Healthcare2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8060Rey, Estela Beatriz; Perez Lana, María Belén; Galluzzo, Liliana; Blanco, Georgina; Onetto, Claudia; et al.; Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?; Informa Healthcare; Gynecological Endocrinology; 29; 2; 2-2013; 141-1440951-3590enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/09513590.2012.730581info:eu-repo/semantics/altIdentifier/doi/10.3109/09513590.2012.730581info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:51:51Zoai:ri.conicet.gov.ar:11336/8060instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:51:51.952CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
title Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
spellingShingle Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
Rey, Estela Beatriz
Polycystic Ovary Sindrome
C-Reactive Protein
Cytokines
title_short Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
title_full Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
title_fullStr Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
title_full_unstemmed Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
title_sort Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
dc.creator.none.fl_str_mv Rey, Estela Beatriz
Perez Lana, María Belén
Galluzzo, Liliana
Blanco, Georgina
Onetto, Claudia
Straminsky, Vanesa
Nolting, Manuel
author Rey, Estela Beatriz
author_facet Rey, Estela Beatriz
Perez Lana, María Belén
Galluzzo, Liliana
Blanco, Georgina
Onetto, Claudia
Straminsky, Vanesa
Nolting, Manuel
author_role author
author2 Perez Lana, María Belén
Galluzzo, Liliana
Blanco, Georgina
Onetto, Claudia
Straminsky, Vanesa
Nolting, Manuel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Polycystic Ovary Sindrome
C-Reactive Protein
Cytokines
topic Polycystic Ovary Sindrome
C-Reactive Protein
Cytokines
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1ß and the hormonal and metabolic alterations in women with polycystic ovary sindrome (PCO). Materials and Methods: Case-control study. CRP, IL-6 and IL-1beta were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control. Results: The average CRP values was 5.1 in the cases vs 0.8 mg/l in control group (P minor 0.0001). The IL-6 average values were 2.77 in the cases vs 2.70 pg/ml in the control group (p=0.254). IL-1beta levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (P minor 0.0001) as well as with the presence of obesity (P minor 0.02). No correlation was found between PCR and hyperandrogenemia (p=0.4) nor between IL-6 values and IR (P =0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (P=0.2). A significant correlation was found between IL-6 levels and obesity (P minor 0.0001). Conclusions: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to insulin resistance.
Fil: Rey, Estela Beatriz. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Perez Lana, María Belén. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Galluzzo, Liliana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Blanco, Georgina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Onetto, Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Straminsky, Vanesa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Nolting, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Aims: To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1ß and the hormonal and metabolic alterations in women with polycystic ovary sindrome (PCO). Materials and Methods: Case-control study. CRP, IL-6 and IL-1beta were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control. Results: The average CRP values was 5.1 in the cases vs 0.8 mg/l in control group (P minor 0.0001). The IL-6 average values were 2.77 in the cases vs 2.70 pg/ml in the control group (p=0.254). IL-1beta levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (P minor 0.0001) as well as with the presence of obesity (P minor 0.02). No correlation was found between PCR and hyperandrogenemia (p=0.4) nor between IL-6 values and IR (P =0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (P=0.2). A significant correlation was found between IL-6 levels and obesity (P minor 0.0001). Conclusions: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to insulin resistance.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8060
Rey, Estela Beatriz; Perez Lana, María Belén; Galluzzo, Liliana; Blanco, Georgina; Onetto, Claudia; et al.; Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?; Informa Healthcare; Gynecological Endocrinology; 29; 2; 2-2013; 141-144
0951-3590
url http://hdl.handle.net/11336/8060
identifier_str_mv Rey, Estela Beatriz; Perez Lana, María Belén; Galluzzo, Liliana; Blanco, Georgina; Onetto, Claudia; et al.; Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?; Informa Healthcare; Gynecological Endocrinology; 29; 2; 2-2013; 141-144
0951-3590
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/09513590.2012.730581
info:eu-repo/semantics/altIdentifier/doi/10.3109/09513590.2012.730581
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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