Iron, zinc, and copper nutritional status in children infected with helicobacter pylori

Autores
Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela; Balcarce, Norma E.; Rua, Eduardo Cueto; Beltrán González, Andrea Natalia; Fuda, Julián Andrés; Meseri, Emiliano I.; Torti, Horacio Emilio; Barrado, Julieta; Zubillaga, Marcela Beatriz; Lopez, Laura Beatriz; Boccio, Jose Ruben
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVE: Helicobacter pylori colonizes the gastric mucosa of about half of the world's population and it has been related to extragastrointestinal diseases. The present study sought to evaluate the association between H pylori infection and iron, zinc, and copper nutritional status in symptomatic children. Patients and Methods: A cross-sectional study was carried out in 395 children (4-16 years) with upper gastrointestinal symptoms, who were tested for H pylori infection by the 13 C-urea breath test. Iron status was determined by hemoglobin, serum ferritin, and serum transferrin receptors. Copper and zinc serum concentrations were also evaluated. Epidemiological data, dietary assessment, and anthropometric indicators were analyzed as potential confounding factors. Results: Prevalence of H pylori infection was 24.3%. Anemia and iron deficiency (ID) were found in 12.0% and 14.3% of the H pylori-positive and 8.9% and 11.0% of the H pylori-negative children, respectively. There was no association between H pylori infection and anemia (odds ratio = 1.54 [95% confidence interval [CI] 0.73%-3.24%]) or ID (odds ratio = 1.35 [95% CI 0.67-2.70]). Crude β coefficients showed that H pylori has no significant effect on hemoglobin, serum ferritin, serum transferrin receptors, copper, and zinc concentrations. However, adjusted results suggested that H pylori-infected children had an increase of 9.74 μg/dL (95% CI 2.12-17.37 μg/dL) in copper concentrations. Conclusions: This study revealed that H pylori infection was not associated with iron deficiency, anemia, or zinc concentrations; however, a positive relation with copper status was found after adjusting for confounding factors. The contribution of H pylori infection to higher copper concentrations needs to be confirmed by additional studies.
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Balcarce, Norma E.. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Rua, Eduardo Cueto. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Beltrán González, Andrea Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Fuda, Julián Andrés. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Meseri, Emiliano I.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Torti, Horacio Emilio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Barrado, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Lopez, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Boccio, Jose Ruben. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Materia
Anemia
Copper
Helicobacter Pylori
Iron Deficiency
Zinc
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79897
Acceder
id CONICETDig_719124ccfbe925c339388b5d8039ea88
oai_identifier_str oai:ri.conicet.gov.ar:11336/79897
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Iron, zinc, and copper nutritional status in children infected with helicobacter pyloriJanjetic, Mariana AndreaGoldman, Cinthia GabrielaBalcarce, Norma E.Rua, Eduardo CuetoBeltrán González, Andrea NataliaFuda, Julián AndrésMeseri, Emiliano I.Torti, Horacio EmilioBarrado, JulietaZubillaga, Marcela BeatrizLopez, Laura BeatrizBoccio, Jose RubenAnemiaCopperHelicobacter PyloriIron DeficiencyZinchttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3OBJECTIVE: Helicobacter pylori colonizes the gastric mucosa of about half of the world's population and it has been related to extragastrointestinal diseases. The present study sought to evaluate the association between H pylori infection and iron, zinc, and copper nutritional status in symptomatic children. Patients and Methods: A cross-sectional study was carried out in 395 children (4-16 years) with upper gastrointestinal symptoms, who were tested for H pylori infection by the 13 C-urea breath test. Iron status was determined by hemoglobin, serum ferritin, and serum transferrin receptors. Copper and zinc serum concentrations were also evaluated. Epidemiological data, dietary assessment, and anthropometric indicators were analyzed as potential confounding factors. Results: Prevalence of H pylori infection was 24.3%. Anemia and iron deficiency (ID) were found in 12.0% and 14.3% of the H pylori-positive and 8.9% and 11.0% of the H pylori-negative children, respectively. There was no association between H pylori infection and anemia (odds ratio = 1.54 [95% confidence interval [CI] 0.73%-3.24%]) or ID (odds ratio = 1.35 [95% CI 0.67-2.70]). Crude β coefficients showed that H pylori has no significant effect on hemoglobin, serum ferritin, serum transferrin receptors, copper, and zinc concentrations. However, adjusted results suggested that H pylori-infected children had an increase of 9.74 μg/dL (95% CI 2.12-17.37 μg/dL) in copper concentrations. Conclusions: This study revealed that H pylori infection was not associated with iron deficiency, anemia, or zinc concentrations; however, a positive relation with copper status was found after adjusting for confounding factors. The contribution of H pylori infection to higher copper concentrations needs to be confirmed by additional studies.Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Balcarce, Norma E.. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Rua, Eduardo Cueto. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Beltrán González, Andrea Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Fuda, Julián Andrés. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Meseri, Emiliano I.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Torti, Horacio Emilio. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Barrado, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Lopez, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Boccio, Jose Ruben. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaLippincott Williams2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79897Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela; Balcarce, Norma E.; Rua, Eduardo Cueto; Beltrán González, Andrea Natalia; et al.; Iron, zinc, and copper nutritional status in children infected with helicobacter pylori; Lippincott Williams; Journal Of Pediatric Gastroenterology And Nutrition; 51; 1; 7-2010; 85-890277-2116CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20410842info:eu-repo/semantics/altIdentifier/doi/10.1097/MPG.0b013e3181c2c2cdinfo:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00005176-201007000-00016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:15Zoai:ri.conicet.gov.ar:11336/79897instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:15.456CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
title Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
spellingShingle Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
Janjetic, Mariana Andrea
Anemia
Copper
Helicobacter Pylori
Iron Deficiency
Zinc
title_short Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
title_full Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
title_fullStr Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
title_full_unstemmed Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
title_sort Iron, zinc, and copper nutritional status in children infected with helicobacter pylori
dc.creator.none.fl_str_mv Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
Balcarce, Norma E.
Rua, Eduardo Cueto
Beltrán González, Andrea Natalia
Fuda, Julián Andrés
Meseri, Emiliano I.
Torti, Horacio Emilio
Barrado, Julieta
Zubillaga, Marcela Beatriz
Lopez, Laura Beatriz
Boccio, Jose Ruben
author Janjetic, Mariana Andrea
author_facet Janjetic, Mariana Andrea
Goldman, Cinthia Gabriela
Balcarce, Norma E.
Rua, Eduardo Cueto
Beltrán González, Andrea Natalia
Fuda, Julián Andrés
Meseri, Emiliano I.
Torti, Horacio Emilio
Barrado, Julieta
Zubillaga, Marcela Beatriz
Lopez, Laura Beatriz
Boccio, Jose Ruben
author_role author
author2 Goldman, Cinthia Gabriela
Balcarce, Norma E.
Rua, Eduardo Cueto
Beltrán González, Andrea Natalia
Fuda, Julián Andrés
Meseri, Emiliano I.
Torti, Horacio Emilio
Barrado, Julieta
Zubillaga, Marcela Beatriz
Lopez, Laura Beatriz
Boccio, Jose Ruben
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anemia
Copper
Helicobacter Pylori
Iron Deficiency
Zinc
topic Anemia
Copper
Helicobacter Pylori
Iron Deficiency
Zinc
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVE: Helicobacter pylori colonizes the gastric mucosa of about half of the world's population and it has been related to extragastrointestinal diseases. The present study sought to evaluate the association between H pylori infection and iron, zinc, and copper nutritional status in symptomatic children. Patients and Methods: A cross-sectional study was carried out in 395 children (4-16 years) with upper gastrointestinal symptoms, who were tested for H pylori infection by the 13 C-urea breath test. Iron status was determined by hemoglobin, serum ferritin, and serum transferrin receptors. Copper and zinc serum concentrations were also evaluated. Epidemiological data, dietary assessment, and anthropometric indicators were analyzed as potential confounding factors. Results: Prevalence of H pylori infection was 24.3%. Anemia and iron deficiency (ID) were found in 12.0% and 14.3% of the H pylori-positive and 8.9% and 11.0% of the H pylori-negative children, respectively. There was no association between H pylori infection and anemia (odds ratio = 1.54 [95% confidence interval [CI] 0.73%-3.24%]) or ID (odds ratio = 1.35 [95% CI 0.67-2.70]). Crude β coefficients showed that H pylori has no significant effect on hemoglobin, serum ferritin, serum transferrin receptors, copper, and zinc concentrations. However, adjusted results suggested that H pylori-infected children had an increase of 9.74 μg/dL (95% CI 2.12-17.37 μg/dL) in copper concentrations. Conclusions: This study revealed that H pylori infection was not associated with iron deficiency, anemia, or zinc concentrations; however, a positive relation with copper status was found after adjusting for confounding factors. The contribution of H pylori infection to higher copper concentrations needs to be confirmed by additional studies.
Fil: Janjetic, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Balcarce, Norma E.. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Rua, Eduardo Cueto. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Beltrán González, Andrea Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Fuda, Julián Andrés. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Meseri, Emiliano I.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Torti, Horacio Emilio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Barrado, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Lopez, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Boccio, Jose Ruben. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
description OBJECTIVE: Helicobacter pylori colonizes the gastric mucosa of about half of the world's population and it has been related to extragastrointestinal diseases. The present study sought to evaluate the association between H pylori infection and iron, zinc, and copper nutritional status in symptomatic children. Patients and Methods: A cross-sectional study was carried out in 395 children (4-16 years) with upper gastrointestinal symptoms, who were tested for H pylori infection by the 13 C-urea breath test. Iron status was determined by hemoglobin, serum ferritin, and serum transferrin receptors. Copper and zinc serum concentrations were also evaluated. Epidemiological data, dietary assessment, and anthropometric indicators were analyzed as potential confounding factors. Results: Prevalence of H pylori infection was 24.3%. Anemia and iron deficiency (ID) were found in 12.0% and 14.3% of the H pylori-positive and 8.9% and 11.0% of the H pylori-negative children, respectively. There was no association between H pylori infection and anemia (odds ratio = 1.54 [95% confidence interval [CI] 0.73%-3.24%]) or ID (odds ratio = 1.35 [95% CI 0.67-2.70]). Crude β coefficients showed that H pylori has no significant effect on hemoglobin, serum ferritin, serum transferrin receptors, copper, and zinc concentrations. However, adjusted results suggested that H pylori-infected children had an increase of 9.74 μg/dL (95% CI 2.12-17.37 μg/dL) in copper concentrations. Conclusions: This study revealed that H pylori infection was not associated with iron deficiency, anemia, or zinc concentrations; however, a positive relation with copper status was found after adjusting for confounding factors. The contribution of H pylori infection to higher copper concentrations needs to be confirmed by additional studies.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79897
Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela; Balcarce, Norma E.; Rua, Eduardo Cueto; Beltrán González, Andrea Natalia; et al.; Iron, zinc, and copper nutritional status in children infected with helicobacter pylori; Lippincott Williams; Journal Of Pediatric Gastroenterology And Nutrition; 51; 1; 7-2010; 85-89
0277-2116
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79897
identifier_str_mv Janjetic, Mariana Andrea; Goldman, Cinthia Gabriela; Balcarce, Norma E.; Rua, Eduardo Cueto; Beltrán González, Andrea Natalia; et al.; Iron, zinc, and copper nutritional status in children infected with helicobacter pylori; Lippincott Williams; Journal Of Pediatric Gastroenterology And Nutrition; 51; 1; 7-2010; 85-89
0277-2116
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20410842
info:eu-repo/semantics/altIdentifier/doi/10.1097/MPG.0b013e3181c2c2cd
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00005176-201007000-00016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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