Sensorimotor Transformations in the Zebrafish Auditory System

Autores
Privat, Martin; Romano, Sebastián Alejo; Pietri, Thomas; Jouary, Adrien; Boulanger Weill, Jonathan; Elbaz, Nicolas; Duchemin, Auriane; Soares, Daphne; Sumbre, Germán
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.
Fil: Privat, Martin. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Romano, Sebastián Alejo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Pietri, Thomas. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Jouary, Adrien. Champalimaud Centre For The Unknown; Portugal. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Elbaz, Nicolas. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Duchemin, Auriane. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Soares, Daphne. New Jersey Institute of Technology; Estados Unidos
Fil: Sumbre, Germán. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Materia
AUDITION
BEHAVIOR
NEURONAL CIRCUIT DYNAMICS
SENSORIMOTOR TRANSFORMATIONS
TWO-PHOTON CALCIUM IMAGING
ZEBRAFISH LARVA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124563
Acceder
id CONICETDig_714840eca226869f7fb737948f809a7b
oai_identifier_str oai:ri.conicet.gov.ar:11336/124563
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sensorimotor Transformations in the Zebrafish Auditory SystemPrivat, MartinRomano, Sebastián AlejoPietri, ThomasJouary, AdrienBoulanger Weill, JonathanElbaz, NicolasDuchemin, AurianeSoares, DaphneSumbre, GermánAUDITIONBEHAVIORNEURONAL CIRCUIT DYNAMICSSENSORIMOTOR TRANSFORMATIONSTWO-PHOTON CALCIUM IMAGINGZEBRAFISH LARVAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.Fil: Privat, Martin. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Romano, Sebastián Alejo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Pietri, Thomas. Centre National de la Recherche Scientifique; Francia. Inserm; FranciaFil: Jouary, Adrien. Champalimaud Centre For The Unknown; Portugal. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique; Francia. Inserm; FranciaFil: Elbaz, Nicolas. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Duchemin, Auriane. Centre National de la Recherche Scientifique; Francia. Inserm; FranciaFil: Soares, Daphne. New Jersey Institute of Technology; Estados UnidosFil: Sumbre, Germán. Centre National de la Recherche Scientifique; Francia. Inserm; FranciaCell Press2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124563Privat, Martin; Romano, Sebastián Alejo; Pietri, Thomas; Jouary, Adrien; Boulanger Weill, Jonathan; et al.; Sensorimotor Transformations in the Zebrafish Auditory System; Cell Press; Current Biology; 29; 23; 11-2019; 4010-4023.e40960-9822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0960982219313600info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2019.10.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:10Zoai:ri.conicet.gov.ar:11336/124563instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:10.321CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensorimotor Transformations in the Zebrafish Auditory System
title Sensorimotor Transformations in the Zebrafish Auditory System
spellingShingle Sensorimotor Transformations in the Zebrafish Auditory System
Privat, Martin
AUDITION
BEHAVIOR
NEURONAL CIRCUIT DYNAMICS
SENSORIMOTOR TRANSFORMATIONS
TWO-PHOTON CALCIUM IMAGING
ZEBRAFISH LARVA
title_short Sensorimotor Transformations in the Zebrafish Auditory System
title_full Sensorimotor Transformations in the Zebrafish Auditory System
title_fullStr Sensorimotor Transformations in the Zebrafish Auditory System
title_full_unstemmed Sensorimotor Transformations in the Zebrafish Auditory System
title_sort Sensorimotor Transformations in the Zebrafish Auditory System
dc.creator.none.fl_str_mv Privat, Martin
Romano, Sebastián Alejo
Pietri, Thomas
Jouary, Adrien
Boulanger Weill, Jonathan
Elbaz, Nicolas
Duchemin, Auriane
Soares, Daphne
Sumbre, Germán
author Privat, Martin
author_facet Privat, Martin
Romano, Sebastián Alejo
Pietri, Thomas
Jouary, Adrien
Boulanger Weill, Jonathan
Elbaz, Nicolas
Duchemin, Auriane
Soares, Daphne
Sumbre, Germán
author_role author
author2 Romano, Sebastián Alejo
Pietri, Thomas
Jouary, Adrien
Boulanger Weill, Jonathan
Elbaz, Nicolas
Duchemin, Auriane
Soares, Daphne
Sumbre, Germán
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AUDITION
BEHAVIOR
NEURONAL CIRCUIT DYNAMICS
SENSORIMOTOR TRANSFORMATIONS
TWO-PHOTON CALCIUM IMAGING
ZEBRAFISH LARVA
topic AUDITION
BEHAVIOR
NEURONAL CIRCUIT DYNAMICS
SENSORIMOTOR TRANSFORMATIONS
TWO-PHOTON CALCIUM IMAGING
ZEBRAFISH LARVA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.
Fil: Privat, Martin. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Romano, Sebastián Alejo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Pietri, Thomas. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Jouary, Adrien. Champalimaud Centre For The Unknown; Portugal. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Elbaz, Nicolas. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Duchemin, Auriane. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
Fil: Soares, Daphne. New Jersey Institute of Technology; Estados Unidos
Fil: Sumbre, Germán. Centre National de la Recherche Scientifique; Francia. Inserm; Francia
description Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124563
Privat, Martin; Romano, Sebastián Alejo; Pietri, Thomas; Jouary, Adrien; Boulanger Weill, Jonathan; et al.; Sensorimotor Transformations in the Zebrafish Auditory System; Cell Press; Current Biology; 29; 23; 11-2019; 4010-4023.e4
0960-9822
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124563
identifier_str_mv Privat, Martin; Romano, Sebastián Alejo; Pietri, Thomas; Jouary, Adrien; Boulanger Weill, Jonathan; et al.; Sensorimotor Transformations in the Zebrafish Auditory System; Cell Press; Current Biology; 29; 23; 11-2019; 4010-4023.e4
0960-9822
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0960982219313600
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2019.10.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613574200131584
score 13.070432

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