Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes

Autores
Rossi, Andrés Hugo; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Aulicino, Paula
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymorphisms occurring at the p6gag protein of HIV-1 have been previously found to have an impact on viral fitness and antiretroviral (ARV) resistance, mainly on subtype B genomes. We compared p6gag variability in a large group of 165 subtype F gag-pol sequences, with 36 subtype B sequences from the same study source, and identified sites of gag-pol coevolution under ARV selection pressure. Subtype-specific differences in the frequency of point mutations, insertions, and deletions previously associated with ARV resistance were found. Also, in our dataset of subtype F genomes a strong association between mutation P5L in the p1/p6 cleavage region of gag and the nelfinavir (NFV) resistance mutation N88DPR was found with no impact on the preference for any of the NFV resistance pathways.
Fil: Rossi, Andrés Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rocco, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Protein
Genomes
Variability
P 6
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23935
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23935
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomesRossi, Andrés HugoRocco, Carlos AlbertoMangano, Andrea María MercedesSen, LuisaAulicino, PaulaProteinGenomesVariabilityP 6https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Polymorphisms occurring at the p6gag protein of HIV-1 have been previously found to have an impact on viral fitness and antiretroviral (ARV) resistance, mainly on subtype B genomes. We compared p6gag variability in a large group of 165 subtype F gag-pol sequences, with 36 subtype B sequences from the same study source, and identified sites of gag-pol coevolution under ARV selection pressure. Subtype-specific differences in the frequency of point mutations, insertions, and deletions previously associated with ARV resistance were found. Also, in our dataset of subtype F genomes a strong association between mutation P5L in the p1/p6 cleavage region of gag and the nelfinavir (NFV) resistance mutation N88DPR was found with no impact on the preference for any of the NFV resistance pathways.Fil: Rossi, Andrés Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rocco, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMary Ann Liebert Inc2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23935Rossi, Andrés Hugo; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Aulicino, Paula; Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes; Mary Ann Liebert Inc; Aids Research and Human Retroviruses; 29; 7; 3-2013; 1056-10600889-2229CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/aid.2012.0311info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2012.0311info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:54Zoai:ri.conicet.gov.ar:11336/23935instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:54.382CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
title Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
spellingShingle Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
Rossi, Andrés Hugo
Protein
Genomes
Variability
P 6
title_short Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
title_full Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
title_fullStr Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
title_full_unstemmed Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
title_sort Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes
dc.creator.none.fl_str_mv Rossi, Andrés Hugo
Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
Aulicino, Paula
author Rossi, Andrés Hugo
author_facet Rossi, Andrés Hugo
Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
Aulicino, Paula
author_role author
author2 Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
Aulicino, Paula
author2_role author
author
author
author
dc.subject.none.fl_str_mv Protein
Genomes
Variability
P 6
topic Protein
Genomes
Variability
P 6
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Polymorphisms occurring at the p6gag protein of HIV-1 have been previously found to have an impact on viral fitness and antiretroviral (ARV) resistance, mainly on subtype B genomes. We compared p6gag variability in a large group of 165 subtype F gag-pol sequences, with 36 subtype B sequences from the same study source, and identified sites of gag-pol coevolution under ARV selection pressure. Subtype-specific differences in the frequency of point mutations, insertions, and deletions previously associated with ARV resistance were found. Also, in our dataset of subtype F genomes a strong association between mutation P5L in the p1/p6 cleavage region of gag and the nelfinavir (NFV) resistance mutation N88DPR was found with no impact on the preference for any of the NFV resistance pathways.
Fil: Rossi, Andrés Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rocco, Carlos Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Laboratorio de Biología Celular y Retrovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Polymorphisms occurring at the p6gag protein of HIV-1 have been previously found to have an impact on viral fitness and antiretroviral (ARV) resistance, mainly on subtype B genomes. We compared p6gag variability in a large group of 165 subtype F gag-pol sequences, with 36 subtype B sequences from the same study source, and identified sites of gag-pol coevolution under ARV selection pressure. Subtype-specific differences in the frequency of point mutations, insertions, and deletions previously associated with ARV resistance were found. Also, in our dataset of subtype F genomes a strong association between mutation P5L in the p1/p6 cleavage region of gag and the nelfinavir (NFV) resistance mutation N88DPR was found with no impact on the preference for any of the NFV resistance pathways.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23935
Rossi, Andrés Hugo; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Aulicino, Paula; Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes; Mary Ann Liebert Inc; Aids Research and Human Retroviruses; 29; 7; 3-2013; 1056-1060
0889-2229
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23935
identifier_str_mv Rossi, Andrés Hugo; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Aulicino, Paula; Sequence variability in p6 gag protein and gag/pol coevolution in Human Immunodeficiency Type 1 Subtype F genomes; Mary Ann Liebert Inc; Aids Research and Human Retroviruses; 29; 7; 3-2013; 1056-1060
0889-2229
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/aid.2012.0311
info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2012.0311
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert Inc
publisher.none.fl_str_mv Mary Ann Liebert Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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