Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding

Autores
González, Ana Silvia; Affranchino, Jose Luis
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural host but is also useful for the development of antiviral strategies directed against HIV-1 infections in humans. FIV assembly results from the multimerization of a single but complex viral polypeptide, the Gag precursor. In this review, we will first give an overview of the current knowledge of the proteins encoded by the FIV pol, env, rev, vif, and orf-A genes, and then we will describe and discuss in detail the critical roles that each of the FIV Gag domains plays in virion morphogenesis. Since retroviral assembly is an attractive target for therapeutic interventions, gaining a better understanding of this process is highly desirable.
Fil: González, Ana Silvia. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; Argentina
Fil: Affranchino, Jose Luis. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
FELINE IMMUNODEFICIENCY VIRUS
GAG POLYPROTEIN
RETROVIRUS ASSEMBLY
RETROVIRUS BUDDING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/176381
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and BuddingGonzález, Ana SilviaAffranchino, Jose LuisFELINE IMMUNODEFICIENCY VIRUSGAG POLYPROTEINRETROVIRUS ASSEMBLYRETROVIRUS BUDDINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural host but is also useful for the development of antiviral strategies directed against HIV-1 infections in humans. FIV assembly results from the multimerization of a single but complex viral polypeptide, the Gag precursor. In this review, we will first give an overview of the current knowledge of the proteins encoded by the FIV pol, env, rev, vif, and orf-A genes, and then we will describe and discuss in detail the critical roles that each of the FIV Gag domains plays in virion morphogenesis. Since retroviral assembly is an attractive target for therapeutic interventions, gaining a better understanding of this process is highly desirable.Fil: González, Ana Silvia. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; ArgentinaFil: Affranchino, Jose Luis. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI AG2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/176381González, Ana Silvia; Affranchino, Jose Luis; Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding; MDPI AG; Viruses; 10; 5; 5-2018; 1-161999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/10/5/261info:eu-repo/semantics/altIdentifier/doi/10.3390/v10050261info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:26Zoai:ri.conicet.gov.ar:11336/176381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:26.47CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
title Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
spellingShingle Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
González, Ana Silvia
FELINE IMMUNODEFICIENCY VIRUS
GAG POLYPROTEIN
RETROVIRUS ASSEMBLY
RETROVIRUS BUDDING
title_short Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
title_full Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
title_fullStr Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
title_full_unstemmed Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
title_sort Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding
dc.creator.none.fl_str_mv González, Ana Silvia
Affranchino, Jose Luis
author González, Ana Silvia
author_facet González, Ana Silvia
Affranchino, Jose Luis
author_role author
author2 Affranchino, Jose Luis
author2_role author
dc.subject.none.fl_str_mv FELINE IMMUNODEFICIENCY VIRUS
GAG POLYPROTEIN
RETROVIRUS ASSEMBLY
RETROVIRUS BUDDING
topic FELINE IMMUNODEFICIENCY VIRUS
GAG POLYPROTEIN
RETROVIRUS ASSEMBLY
RETROVIRUS BUDDING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural host but is also useful for the development of antiviral strategies directed against HIV-1 infections in humans. FIV assembly results from the multimerization of a single but complex viral polypeptide, the Gag precursor. In this review, we will first give an overview of the current knowledge of the proteins encoded by the FIV pol, env, rev, vif, and orf-A genes, and then we will describe and discuss in detail the critical roles that each of the FIV Gag domains plays in virion morphogenesis. Since retroviral assembly is an attractive target for therapeutic interventions, gaining a better understanding of this process is highly desirable.
Fil: González, Ana Silvia. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; Argentina
Fil: Affranchino, Jose Luis. Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural host but is also useful for the development of antiviral strategies directed against HIV-1 infections in humans. FIV assembly results from the multimerization of a single but complex viral polypeptide, the Gag precursor. In this review, we will first give an overview of the current knowledge of the proteins encoded by the FIV pol, env, rev, vif, and orf-A genes, and then we will describe and discuss in detail the critical roles that each of the FIV Gag domains plays in virion morphogenesis. Since retroviral assembly is an attractive target for therapeutic interventions, gaining a better understanding of this process is highly desirable.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/176381
González, Ana Silvia; Affranchino, Jose Luis; Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding; MDPI AG; Viruses; 10; 5; 5-2018; 1-16
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/176381
identifier_str_mv González, Ana Silvia; Affranchino, Jose Luis; Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding; MDPI AG; Viruses; 10; 5; 5-2018; 1-16
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/10/5/261
info:eu-repo/semantics/altIdentifier/doi/10.3390/v10050261
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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