Molecular epidemiology of hepatitis B virus in Córdoba, Argentina

Autores
Gallego, Fernando; Pisano, María Belén; Torres, Carolina; Caeiro, Luciana; Martinez Wassaf, Maribel Graciela; Balangero, Marcos Cesar; Campos, Rodolfo Hector; Ré, Viviana Elizabeth
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The analysis of the genomes of hepatitis B virus (HBV) identifies phylogenetic variants calledgenotypes, which may lead to distinct biological and clinical behaviors.Objectives: The aim of this study was to describe the current molecular epidemiology and genetic diversityof HBV in Córdoba, Argentina. Study design: A total of 52 HBV samples, 40 from HBV mono-infected and 12 from human immuno-deficiency virus (HIV)-HBV co-infected patients, were sequenced in the S gene and in the basal corepromoter-precore (BCP-pC) region.Results: Presence of subgenotypes F1b (35%) and F4 (17.5%), subgenotype A2 (37.5%), C (5.0%) (subgeno-type could not be defined) and D (5.0%) (subgenotype D2, and the other could not be defined) wereobserved among mono-infected patients. The co-infected individuals displayed a different genotypedistribution: sub-genotype A2 was the most common (75.0%), followed by subgenotype F1b (25.0%).Conclusions: These results showed two epidemiologic scenarios: the mono-infected population may rep-resent the ethnic composition of the current human population of Córdoba, where the Amerindian(genotype F) and European origins (subgenotype A2) account for the 90% of the samples; for the co-infected patients, the high prevalence of subgenotype A2 resemble previous analyses from Buenos Aires.In addition, mutations in hepatitis B surface antigen (HBsAg), polymerase and BCP-pC regions wereidentified, mainly in chronic or co-infected patients.
Fil: Gallego, Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Torres, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Caeiro, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Martinez Wassaf, Maribel Graciela. Lace Laboratorios S.a.; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Balangero, Marcos Cesar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Materia
HBV
GENOTYPES
ARGENTINA
HBV/HIV CO-INFECTION
MUTANTS
EPIDEMIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104950
Acceder
id CONICETDig_6ff851c21a62b162d46da6fd0be2614c
oai_identifier_str oai:ri.conicet.gov.ar:11336/104950
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Molecular epidemiology of hepatitis B virus in Córdoba, ArgentinaGallego, FernandoPisano, María BelénTorres, CarolinaCaeiro, LucianaMartinez Wassaf, Maribel GracielaBalangero, Marcos CesarCampos, Rodolfo HectorRé, Viviana ElizabethHBVGENOTYPESARGENTINAHBV/HIV CO-INFECTIONMUTANTSEPIDEMIOLOGYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The analysis of the genomes of hepatitis B virus (HBV) identifies phylogenetic variants calledgenotypes, which may lead to distinct biological and clinical behaviors.Objectives: The aim of this study was to describe the current molecular epidemiology and genetic diversityof HBV in Córdoba, Argentina. Study design: A total of 52 HBV samples, 40 from HBV mono-infected and 12 from human immuno-deficiency virus (HIV)-HBV co-infected patients, were sequenced in the S gene and in the basal corepromoter-precore (BCP-pC) region.Results: Presence of subgenotypes F1b (35%) and F4 (17.5%), subgenotype A2 (37.5%), C (5.0%) (subgeno-type could not be defined) and D (5.0%) (subgenotype D2, and the other could not be defined) wereobserved among mono-infected patients. The co-infected individuals displayed a different genotypedistribution: sub-genotype A2 was the most common (75.0%), followed by subgenotype F1b (25.0%).Conclusions: These results showed two epidemiologic scenarios: the mono-infected population may rep-resent the ethnic composition of the current human population of Córdoba, where the Amerindian(genotype F) and European origins (subgenotype A2) account for the 90% of the samples; for the co-infected patients, the high prevalence of subgenotype A2 resemble previous analyses from Buenos Aires.In addition, mutations in hepatitis B surface antigen (HBsAg), polymerase and BCP-pC regions wereidentified, mainly in chronic or co-infected patients.Fil: Gallego, Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Torres, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Caeiro, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Martinez Wassaf, Maribel Graciela. Lace Laboratorios S.a.; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Balangero, Marcos Cesar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaElsevier Science2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104950Gallego, Fernando; Pisano, María Belén; Torres, Carolina; Caeiro, Luciana; Martinez Wassaf, Maribel Graciela; et al.; Molecular epidemiology of hepatitis B virus in Córdoba, Argentina; Elsevier Science; Journal of Clinical Virology; 61; 10; 10-2014; 204-20101386-6532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1386653214002637info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.06.030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:54:05Zoai:ri.conicet.gov.ar:11336/104950instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:54:05.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
title Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
spellingShingle Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
Gallego, Fernando
HBV
GENOTYPES
ARGENTINA
HBV/HIV CO-INFECTION
MUTANTS
EPIDEMIOLOGY
title_short Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
title_full Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
title_fullStr Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
title_full_unstemmed Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
title_sort Molecular epidemiology of hepatitis B virus in Córdoba, Argentina
dc.creator.none.fl_str_mv Gallego, Fernando
Pisano, María Belén
Torres, Carolina
Caeiro, Luciana
Martinez Wassaf, Maribel Graciela
Balangero, Marcos Cesar
Campos, Rodolfo Hector
Ré, Viviana Elizabeth
author Gallego, Fernando
author_facet Gallego, Fernando
Pisano, María Belén
Torres, Carolina
Caeiro, Luciana
Martinez Wassaf, Maribel Graciela
Balangero, Marcos Cesar
Campos, Rodolfo Hector
Ré, Viviana Elizabeth
author_role author
author2 Pisano, María Belén
Torres, Carolina
Caeiro, Luciana
Martinez Wassaf, Maribel Graciela
Balangero, Marcos Cesar
Campos, Rodolfo Hector
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HBV
GENOTYPES
ARGENTINA
HBV/HIV CO-INFECTION
MUTANTS
EPIDEMIOLOGY
topic HBV
GENOTYPES
ARGENTINA
HBV/HIV CO-INFECTION
MUTANTS
EPIDEMIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The analysis of the genomes of hepatitis B virus (HBV) identifies phylogenetic variants calledgenotypes, which may lead to distinct biological and clinical behaviors.Objectives: The aim of this study was to describe the current molecular epidemiology and genetic diversityof HBV in Córdoba, Argentina. Study design: A total of 52 HBV samples, 40 from HBV mono-infected and 12 from human immuno-deficiency virus (HIV)-HBV co-infected patients, were sequenced in the S gene and in the basal corepromoter-precore (BCP-pC) region.Results: Presence of subgenotypes F1b (35%) and F4 (17.5%), subgenotype A2 (37.5%), C (5.0%) (subgeno-type could not be defined) and D (5.0%) (subgenotype D2, and the other could not be defined) wereobserved among mono-infected patients. The co-infected individuals displayed a different genotypedistribution: sub-genotype A2 was the most common (75.0%), followed by subgenotype F1b (25.0%).Conclusions: These results showed two epidemiologic scenarios: the mono-infected population may rep-resent the ethnic composition of the current human population of Córdoba, where the Amerindian(genotype F) and European origins (subgenotype A2) account for the 90% of the samples; for the co-infected patients, the high prevalence of subgenotype A2 resemble previous analyses from Buenos Aires.In addition, mutations in hepatitis B surface antigen (HBsAg), polymerase and BCP-pC regions wereidentified, mainly in chronic or co-infected patients.
Fil: Gallego, Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Torres, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Caeiro, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Martinez Wassaf, Maribel Graciela. Lace Laboratorios S.a.; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Balangero, Marcos Cesar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
description The analysis of the genomes of hepatitis B virus (HBV) identifies phylogenetic variants calledgenotypes, which may lead to distinct biological and clinical behaviors.Objectives: The aim of this study was to describe the current molecular epidemiology and genetic diversityof HBV in Córdoba, Argentina. Study design: A total of 52 HBV samples, 40 from HBV mono-infected and 12 from human immuno-deficiency virus (HIV)-HBV co-infected patients, were sequenced in the S gene and in the basal corepromoter-precore (BCP-pC) region.Results: Presence of subgenotypes F1b (35%) and F4 (17.5%), subgenotype A2 (37.5%), C (5.0%) (subgeno-type could not be defined) and D (5.0%) (subgenotype D2, and the other could not be defined) wereobserved among mono-infected patients. The co-infected individuals displayed a different genotypedistribution: sub-genotype A2 was the most common (75.0%), followed by subgenotype F1b (25.0%).Conclusions: These results showed two epidemiologic scenarios: the mono-infected population may rep-resent the ethnic composition of the current human population of Córdoba, where the Amerindian(genotype F) and European origins (subgenotype A2) account for the 90% of the samples; for the co-infected patients, the high prevalence of subgenotype A2 resemble previous analyses from Buenos Aires.In addition, mutations in hepatitis B surface antigen (HBsAg), polymerase and BCP-pC regions wereidentified, mainly in chronic or co-infected patients.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104950
Gallego, Fernando; Pisano, María Belén; Torres, Carolina; Caeiro, Luciana; Martinez Wassaf, Maribel Graciela; et al.; Molecular epidemiology of hepatitis B virus in Córdoba, Argentina; Elsevier Science; Journal of Clinical Virology; 61; 10; 10-2014; 204-2010
1386-6532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104950
identifier_str_mv Gallego, Fernando; Pisano, María Belén; Torres, Carolina; Caeiro, Luciana; Martinez Wassaf, Maribel Graciela; et al.; Molecular epidemiology of hepatitis B virus in Córdoba, Argentina; Elsevier Science; Journal of Clinical Virology; 61; 10; 10-2014; 204-2010
1386-6532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1386653214002637
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.06.030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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