Enalapril:β-CD complex: Stability enhancement in solid state

Autores
Zoppi, Ariana; Garnero, Claudia; Garro Linck, Yamila; Chattah, Ana Karina; Monti, Gustavo Alberto; Longhi, Marcela Raquel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Complexation of enalapril maleate with -cyclodextrin was used to overcome the known enalapril maleate–excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 ◦C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate in the complex form was more stable than the drug alone, with the drug recovery after 6 month being: 95±1% and 82.1±0.5%, respectively. This satisfactory high stability of the enalapril:-CD complex will be potentially useful for its application as solid pharmaceutical dosage products.
Fil: Zoppi, Ariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
CHEMICAL STABILITY
COMPLEXATION
CYCLODEXTRINS
SOLID STATE NMR
THERMOGRAVIMETRIC ANALYSIS
X-RAY POWDER DIFFRACTOMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/190863
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/190863
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Enalapril:β-CD complex: Stability enhancement in solid stateZoppi, ArianaGarnero, ClaudiaGarro Linck, YamilaChattah, Ana KarinaMonti, Gustavo AlbertoLonghi, Marcela RaquelCHEMICAL STABILITYCOMPLEXATIONCYCLODEXTRINSSOLID STATE NMRTHERMOGRAVIMETRIC ANALYSISX-RAY POWDER DIFFRACTOMETRYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Complexation of enalapril maleate with -cyclodextrin was used to overcome the known enalapril maleate–excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 ◦C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate in the complex form was more stable than the drug alone, with the drug recovery after 6 month being: 95±1% and 82.1±0.5%, respectively. This satisfactory high stability of the enalapril:-CD complex will be potentially useful for its application as solid pharmaceutical dosage products.Fil: Zoppi, Ariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaElsevier2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/190863Zoppi, Ariana; Garnero, Claudia; Garro Linck, Yamila; Chattah, Ana Karina; Monti, Gustavo Alberto; et al.; Enalapril:β-CD complex: Stability enhancement in solid state; Elsevier; Carbohydrate Polymers; 86; 2; 8-2011; 716-7210144-8617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0144861711003870info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2011.05.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:37Zoai:ri.conicet.gov.ar:11336/190863instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:37.489CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Enalapril:β-CD complex: Stability enhancement in solid state
title Enalapril:β-CD complex: Stability enhancement in solid state
spellingShingle Enalapril:β-CD complex: Stability enhancement in solid state
Zoppi, Ariana
CHEMICAL STABILITY
COMPLEXATION
CYCLODEXTRINS
SOLID STATE NMR
THERMOGRAVIMETRIC ANALYSIS
X-RAY POWDER DIFFRACTOMETRY
title_short Enalapril:β-CD complex: Stability enhancement in solid state
title_full Enalapril:β-CD complex: Stability enhancement in solid state
title_fullStr Enalapril:β-CD complex: Stability enhancement in solid state
title_full_unstemmed Enalapril:β-CD complex: Stability enhancement in solid state
title_sort Enalapril:β-CD complex: Stability enhancement in solid state
dc.creator.none.fl_str_mv Zoppi, Ariana
Garnero, Claudia
Garro Linck, Yamila
Chattah, Ana Karina
Monti, Gustavo Alberto
Longhi, Marcela Raquel
author Zoppi, Ariana
author_facet Zoppi, Ariana
Garnero, Claudia
Garro Linck, Yamila
Chattah, Ana Karina
Monti, Gustavo Alberto
Longhi, Marcela Raquel
author_role author
author2 Garnero, Claudia
Garro Linck, Yamila
Chattah, Ana Karina
Monti, Gustavo Alberto
Longhi, Marcela Raquel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHEMICAL STABILITY
COMPLEXATION
CYCLODEXTRINS
SOLID STATE NMR
THERMOGRAVIMETRIC ANALYSIS
X-RAY POWDER DIFFRACTOMETRY
topic CHEMICAL STABILITY
COMPLEXATION
CYCLODEXTRINS
SOLID STATE NMR
THERMOGRAVIMETRIC ANALYSIS
X-RAY POWDER DIFFRACTOMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Complexation of enalapril maleate with -cyclodextrin was used to overcome the known enalapril maleate–excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 ◦C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate in the complex form was more stable than the drug alone, with the drug recovery after 6 month being: 95±1% and 82.1±0.5%, respectively. This satisfactory high stability of the enalapril:-CD complex will be potentially useful for its application as solid pharmaceutical dosage products.
Fil: Zoppi, Ariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Complexation of enalapril maleate with -cyclodextrin was used to overcome the known enalapril maleate–excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 ◦C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate in the complex form was more stable than the drug alone, with the drug recovery after 6 month being: 95±1% and 82.1±0.5%, respectively. This satisfactory high stability of the enalapril:-CD complex will be potentially useful for its application as solid pharmaceutical dosage products.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/190863
Zoppi, Ariana; Garnero, Claudia; Garro Linck, Yamila; Chattah, Ana Karina; Monti, Gustavo Alberto; et al.; Enalapril:β-CD complex: Stability enhancement in solid state; Elsevier; Carbohydrate Polymers; 86; 2; 8-2011; 716-721
0144-8617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/190863
identifier_str_mv Zoppi, Ariana; Garnero, Claudia; Garro Linck, Yamila; Chattah, Ana Karina; Monti, Gustavo Alberto; et al.; Enalapril:β-CD complex: Stability enhancement in solid state; Elsevier; Carbohydrate Polymers; 86; 2; 8-2011; 716-721
0144-8617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0144861711003870
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2011.05.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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