Green synthesis of silver nanoparticles aimed at improving theranostics

Autores
Vedelago, José Alberto; Gomez, Cesar Gerardo; Valente, Mauro Andres; Mattea, Facundo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nowadays, the combination of diagnosis and therapy, known as theranostics, is one of the keys for an optimal treatment for cancer diseases. Theranostics can be significantly improved by incorporating metallic nanoparticles that are specifically delivered and accumulated in cancerous tissue. In this context, precise knowledge about dosimetric effects in nanoparticle-infused tissues as well as the detection and processing of emerging radiation are extremely important issues. In the last years the first studies on theranostic nanomaterials in gel dosimetry have been presented but there is still a broad field of study to explore. Most of gel dosimetric materials are extremely sensible to modifications in their composition, the addition of enhancers, metallic or inorganic charges can alter their stability and dosimetric properties; therefore, thorough studies must be made before the incorporation of any type of modifier. In this work, the synthesis of metallic nanoparticles suitable for gel dosimetry for x-ray applications is presented. A green synthesis process of silver nanoparticles coated with porcine skin gelatin by thermal reduction of silver nitrate is presented. Nanoparticles were obtained and purified for their application in gel dosimetry. Also, nanoparticles size distribution, reaction yield and the preliminar application as theranostic agents were tested in Fricke gel dosimetry in the keV range. The obtained nanoparticles were successfully used in theranostic applications acting as fluorescent agents and dose enhancers in X-ray beam irradiation simultaneously.
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Gomez, Cesar Gerardo. Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Córdoba, CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Materia
AG NPS
GREEN SYNTHESIS
TEM
THERANOSTICS
X-RAY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91584
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/91584
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Green synthesis of silver nanoparticles aimed at improving theranosticsVedelago, José AlbertoGomez, Cesar GerardoValente, Mauro AndresMattea, FacundoAG NPSGREEN SYNTHESISTEMTHERANOSTICSX-RAYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nowadays, the combination of diagnosis and therapy, known as theranostics, is one of the keys for an optimal treatment for cancer diseases. Theranostics can be significantly improved by incorporating metallic nanoparticles that are specifically delivered and accumulated in cancerous tissue. In this context, precise knowledge about dosimetric effects in nanoparticle-infused tissues as well as the detection and processing of emerging radiation are extremely important issues. In the last years the first studies on theranostic nanomaterials in gel dosimetry have been presented but there is still a broad field of study to explore. Most of gel dosimetric materials are extremely sensible to modifications in their composition, the addition of enhancers, metallic or inorganic charges can alter their stability and dosimetric properties; therefore, thorough studies must be made before the incorporation of any type of modifier. In this work, the synthesis of metallic nanoparticles suitable for gel dosimetry for x-ray applications is presented. A green synthesis process of silver nanoparticles coated with porcine skin gelatin by thermal reduction of silver nitrate is presented. Nanoparticles were obtained and purified for their application in gel dosimetry. Also, nanoparticles size distribution, reaction yield and the preliminar application as theranostic agents were tested in Fricke gel dosimetry in the keV range. The obtained nanoparticles were successfully used in theranostic applications acting as fluorescent agents and dose enhancers in X-ray beam irradiation simultaneously.Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Gomez, Cesar Gerardo. Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Córdoba, CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; ChileFil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaPergamon-Elsevier Science Ltd2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91584Vedelago, José Alberto; Gomez, Cesar Gerardo; Valente, Mauro Andres; Mattea, Facundo; Green synthesis of silver nanoparticles aimed at improving theranostics; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 146; 5-2018; 55-670969-806XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969806X17309945info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2018.01.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:08:16Zoai:ri.conicet.gov.ar:11336/91584instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:08:17.068CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Green synthesis of silver nanoparticles aimed at improving theranostics
title Green synthesis of silver nanoparticles aimed at improving theranostics
spellingShingle Green synthesis of silver nanoparticles aimed at improving theranostics
Vedelago, José Alberto
AG NPS
GREEN SYNTHESIS
TEM
THERANOSTICS
X-RAY
title_short Green synthesis of silver nanoparticles aimed at improving theranostics
title_full Green synthesis of silver nanoparticles aimed at improving theranostics
title_fullStr Green synthesis of silver nanoparticles aimed at improving theranostics
title_full_unstemmed Green synthesis of silver nanoparticles aimed at improving theranostics
title_sort Green synthesis of silver nanoparticles aimed at improving theranostics
dc.creator.none.fl_str_mv Vedelago, José Alberto
Gomez, Cesar Gerardo
Valente, Mauro Andres
Mattea, Facundo
author Vedelago, José Alberto
author_facet Vedelago, José Alberto
Gomez, Cesar Gerardo
Valente, Mauro Andres
Mattea, Facundo
author_role author
author2 Gomez, Cesar Gerardo
Valente, Mauro Andres
Mattea, Facundo
author2_role author
author
author
dc.subject.none.fl_str_mv AG NPS
GREEN SYNTHESIS
TEM
THERANOSTICS
X-RAY
topic AG NPS
GREEN SYNTHESIS
TEM
THERANOSTICS
X-RAY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nowadays, the combination of diagnosis and therapy, known as theranostics, is one of the keys for an optimal treatment for cancer diseases. Theranostics can be significantly improved by incorporating metallic nanoparticles that are specifically delivered and accumulated in cancerous tissue. In this context, precise knowledge about dosimetric effects in nanoparticle-infused tissues as well as the detection and processing of emerging radiation are extremely important issues. In the last years the first studies on theranostic nanomaterials in gel dosimetry have been presented but there is still a broad field of study to explore. Most of gel dosimetric materials are extremely sensible to modifications in their composition, the addition of enhancers, metallic or inorganic charges can alter their stability and dosimetric properties; therefore, thorough studies must be made before the incorporation of any type of modifier. In this work, the synthesis of metallic nanoparticles suitable for gel dosimetry for x-ray applications is presented. A green synthesis process of silver nanoparticles coated with porcine skin gelatin by thermal reduction of silver nitrate is presented. Nanoparticles were obtained and purified for their application in gel dosimetry. Also, nanoparticles size distribution, reaction yield and the preliminar application as theranostic agents were tested in Fricke gel dosimetry in the keV range. The obtained nanoparticles were successfully used in theranostic applications acting as fluorescent agents and dose enhancers in X-ray beam irradiation simultaneously.
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Gomez, Cesar Gerardo. Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Córdoba, CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
description Nowadays, the combination of diagnosis and therapy, known as theranostics, is one of the keys for an optimal treatment for cancer diseases. Theranostics can be significantly improved by incorporating metallic nanoparticles that are specifically delivered and accumulated in cancerous tissue. In this context, precise knowledge about dosimetric effects in nanoparticle-infused tissues as well as the detection and processing of emerging radiation are extremely important issues. In the last years the first studies on theranostic nanomaterials in gel dosimetry have been presented but there is still a broad field of study to explore. Most of gel dosimetric materials are extremely sensible to modifications in their composition, the addition of enhancers, metallic or inorganic charges can alter their stability and dosimetric properties; therefore, thorough studies must be made before the incorporation of any type of modifier. In this work, the synthesis of metallic nanoparticles suitable for gel dosimetry for x-ray applications is presented. A green synthesis process of silver nanoparticles coated with porcine skin gelatin by thermal reduction of silver nitrate is presented. Nanoparticles were obtained and purified for their application in gel dosimetry. Also, nanoparticles size distribution, reaction yield and the preliminar application as theranostic agents were tested in Fricke gel dosimetry in the keV range. The obtained nanoparticles were successfully used in theranostic applications acting as fluorescent agents and dose enhancers in X-ray beam irradiation simultaneously.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91584
Vedelago, José Alberto; Gomez, Cesar Gerardo; Valente, Mauro Andres; Mattea, Facundo; Green synthesis of silver nanoparticles aimed at improving theranostics; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 146; 5-2018; 55-67
0969-806X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91584
identifier_str_mv Vedelago, José Alberto; Gomez, Cesar Gerardo; Valente, Mauro Andres; Mattea, Facundo; Green synthesis of silver nanoparticles aimed at improving theranostics; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 146; 5-2018; 55-67
0969-806X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969806X17309945
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2018.01.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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