Ubiquitin-proteasome signaling in lung injury

Autores
Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos
Fil: Dada, Laura Andrea. Northwestern University; Estados Unidos
Fil: Sznajder, Jacob I.. Northwestern University; Estados Unidos
Materia
Ubiquitin
Lung injury
Proteosome signaling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161156
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/161156
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ubiquitin-proteasome signaling in lung injuryMagnani, Natalia DanielaDada, Laura AndreaSznajder, Jacob I.UbiquitinLung injuryProteosome signalinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados UnidosFil: Dada, Laura Andrea. Northwestern University; Estados UnidosFil: Sznajder, Jacob I.. Northwestern University; Estados UnidosElsevier Science Inc.2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161156Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-391931-5244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574info:eu-repo/semantics/altIdentifier/doi/10.1016/j.trsl.2018.04.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:59Zoai:ri.conicet.gov.ar:11336/161156instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:59.262CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ubiquitin-proteasome signaling in lung injury
title Ubiquitin-proteasome signaling in lung injury
spellingShingle Ubiquitin-proteasome signaling in lung injury
Magnani, Natalia Daniela
Ubiquitin
Lung injury
Proteosome signaling
title_short Ubiquitin-proteasome signaling in lung injury
title_full Ubiquitin-proteasome signaling in lung injury
title_fullStr Ubiquitin-proteasome signaling in lung injury
title_full_unstemmed Ubiquitin-proteasome signaling in lung injury
title_sort Ubiquitin-proteasome signaling in lung injury
dc.creator.none.fl_str_mv Magnani, Natalia Daniela
Dada, Laura Andrea
Sznajder, Jacob I.
author Magnani, Natalia Daniela
author_facet Magnani, Natalia Daniela
Dada, Laura Andrea
Sznajder, Jacob I.
author_role author
author2 Dada, Laura Andrea
Sznajder, Jacob I.
author2_role author
author
dc.subject.none.fl_str_mv Ubiquitin
Lung injury
Proteosome signaling
topic Ubiquitin
Lung injury
Proteosome signaling
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos
Fil: Dada, Laura Andrea. Northwestern University; Estados Unidos
Fil: Sznajder, Jacob I.. Northwestern University; Estados Unidos
description Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161156
Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39
1931-5244
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161156
identifier_str_mv Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39
1931-5244
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.trsl.2018.04.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613797397921792
score 13.069144

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