Ubiquitin-proteasome signaling in lung injury
- Autores
- Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos
Fil: Dada, Laura Andrea. Northwestern University; Estados Unidos
Fil: Sznajder, Jacob I.. Northwestern University; Estados Unidos - Materia
-
Ubiquitin
Lung injury
Proteosome signaling - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/161156
Ver los metadatos del registro completo
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Ubiquitin-proteasome signaling in lung injuryMagnani, Natalia DanielaDada, Laura AndreaSznajder, Jacob I.UbiquitinLung injuryProteosome signalinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados UnidosFil: Dada, Laura Andrea. Northwestern University; Estados UnidosFil: Sznajder, Jacob I.. Northwestern University; Estados UnidosElsevier Science Inc.2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161156Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-391931-5244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574info:eu-repo/semantics/altIdentifier/doi/10.1016/j.trsl.2018.04.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:33Zoai:ri.conicet.gov.ar:11336/161156instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:34.24CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ubiquitin-proteasome signaling in lung injury |
title |
Ubiquitin-proteasome signaling in lung injury |
spellingShingle |
Ubiquitin-proteasome signaling in lung injury Magnani, Natalia Daniela Ubiquitin Lung injury Proteosome signaling |
title_short |
Ubiquitin-proteasome signaling in lung injury |
title_full |
Ubiquitin-proteasome signaling in lung injury |
title_fullStr |
Ubiquitin-proteasome signaling in lung injury |
title_full_unstemmed |
Ubiquitin-proteasome signaling in lung injury |
title_sort |
Ubiquitin-proteasome signaling in lung injury |
dc.creator.none.fl_str_mv |
Magnani, Natalia Daniela Dada, Laura Andrea Sznajder, Jacob I. |
author |
Magnani, Natalia Daniela |
author_facet |
Magnani, Natalia Daniela Dada, Laura Andrea Sznajder, Jacob I. |
author_role |
author |
author2 |
Dada, Laura Andrea Sznajder, Jacob I. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ubiquitin Lung injury Proteosome signaling |
topic |
Ubiquitin Lung injury Proteosome signaling |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways. Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos Fil: Dada, Laura Andrea. Northwestern University; Estados Unidos Fil: Sznajder, Jacob I.. Northwestern University; Estados Unidos |
description |
Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/161156 Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39 1931-5244 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/161156 |
identifier_str_mv |
Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39 1931-5244 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.trsl.2018.04.003 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc. |
publisher.none.fl_str_mv |
Elsevier Science Inc. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269409632059392 |
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13.13397 |