Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting
- Autores
- Files, D. Clark; Liu, Chun; Pereyra, Andrea Soledad; Wang, Zhong Min; Aggarwal, Neil; D´Alessio, Franco; Garibaldi, Brian T.; Mock, Jason R.; Singer, Benjamin D.; Feng, Xin; Yammani, Raghunatha R.; Zhang, Tan; Lee, Amy L.; Philpott, Sydney; Lussier, Stephanie; Purcell, Lina; Chou, Jeff; Seeds, Michael; King, Landon S.; Morris, Peter E.; Delbono, Osvaldo
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans.
Fil: Files, D. Clark. School Of Medicine; Estados Unidos
Fil: Liu, Chun. School Of Medicine; Estados Unidos
Fil: Pereyra, Andrea Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Wang, Zhong Min. University Wake Forest; Estados Unidos. School Of Medicine; Estados Unidos
Fil: Aggarwal, Neil. Johns Hopkins Asthma And Allergy Center; Estados Unidos
Fil: D´Alessio, Franco. Johns Hopkins Asthma And Allergy Center; Estados Unidos
Fil: Garibaldi, Brian T.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
Fil: Mock, Jason R.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
Fil: Singer, Benjamin D.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
Fil: Feng, Xin. Wake Forest School of Medicine; Estados Unidos
Fil: Yammani, Raghunatha R.. Wake Forest School of Medicine; Estados Unidos
Fil: Zhang, Tan. Wake Forest School of Medicine; Estados Unidos
Fil: Lee, Amy L.. Wake Forest School of Medicine; Estados Unidos
Fil: Philpott, Sydney. Wake Forest School of Medicine; Estados Unidos
Fil: Lussier, Stephanie. Wake Forest School of Medicine; Estados Unidos
Fil: Purcell, Lina. Wake Forest School of Medicine; Estados Unidos
Fil: Chou, Jeff. Wake Forest School of Medicine; Estados Unidos
Fil: Seeds, Michael. Wake Forest School of Medicine; Estados Unidos
Fil: King, Landon S.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
Fil: Morris, Peter E.. Wake Forest School of Medicine; Estados Unidos
Fil: Delbono, Osvaldo. School Of Medicine; Estados Unidos - Materia
-
LUNG INJURY
EXERCISE
SKELETAL MUSCLE WASTING - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/125093
Ver los metadatos del registro completo
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Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wastingFiles, D. ClarkLiu, ChunPereyra, Andrea SoledadWang, Zhong MinAggarwal, NeilD´Alessio, FrancoGaribaldi, Brian T.Mock, Jason R.Singer, Benjamin D.Feng, XinYammani, Raghunatha R.Zhang, TanLee, Amy L.Philpott, SydneyLussier, StephaniePurcell, LinaChou, JeffSeeds, MichaelKing, Landon S.Morris, Peter E.Delbono, OsvaldoLUNG INJURYEXERCISESKELETAL MUSCLE WASTINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans.Fil: Files, D. Clark. School Of Medicine; Estados UnidosFil: Liu, Chun. School Of Medicine; Estados UnidosFil: Pereyra, Andrea Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Wang, Zhong Min. University Wake Forest; Estados Unidos. School Of Medicine; Estados UnidosFil: Aggarwal, Neil. Johns Hopkins Asthma And Allergy Center; Estados UnidosFil: D´Alessio, Franco. Johns Hopkins Asthma And Allergy Center; Estados UnidosFil: Garibaldi, Brian T.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Mock, Jason R.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Singer, Benjamin D.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Feng, Xin. Wake Forest School of Medicine; Estados UnidosFil: Yammani, Raghunatha R.. Wake Forest School of Medicine; Estados UnidosFil: Zhang, Tan. Wake Forest School of Medicine; Estados UnidosFil: Lee, Amy L.. Wake Forest School of Medicine; Estados UnidosFil: Philpott, Sydney. Wake Forest School of Medicine; Estados UnidosFil: Lussier, Stephanie. Wake Forest School of Medicine; Estados UnidosFil: Purcell, Lina. Wake Forest School of Medicine; Estados UnidosFil: Chou, Jeff. Wake Forest School of Medicine; Estados UnidosFil: Seeds, Michael. Wake Forest School of Medicine; Estados UnidosFil: King, Landon S.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Morris, Peter E.. Wake Forest School of Medicine; Estados UnidosFil: Delbono, Osvaldo. School Of Medicine; Estados UnidosAmerican Association for the Advancement of Science2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125093Files, D. Clark; Liu, Chun; Pereyra, Andrea Soledad; Wang, Zhong Min; Aggarwal, Neil; et al.; Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting; American Association for the Advancement of Science; SCIENCE TRANSLATIONAL MEDICINE; 7; 278; 3-2015; 278-3101946-6234CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://stm.sciencemag.org/content/7/278/278ra32info:eu-repo/semantics/altIdentifier/doi/10.1126/scitranslmed.3010283info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820823/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:02Zoai:ri.conicet.gov.ar:11336/125093instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:03.189CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| title |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| spellingShingle |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting Files, D. Clark LUNG INJURY EXERCISE SKELETAL MUSCLE WASTING |
| title_short |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| title_full |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| title_fullStr |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| title_full_unstemmed |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| title_sort |
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting |
| dc.creator.none.fl_str_mv |
Files, D. Clark Liu, Chun Pereyra, Andrea Soledad Wang, Zhong Min Aggarwal, Neil D´Alessio, Franco Garibaldi, Brian T. Mock, Jason R. Singer, Benjamin D. Feng, Xin Yammani, Raghunatha R. Zhang, Tan Lee, Amy L. Philpott, Sydney Lussier, Stephanie Purcell, Lina Chou, Jeff Seeds, Michael King, Landon S. Morris, Peter E. Delbono, Osvaldo |
| author |
Files, D. Clark |
| author_facet |
Files, D. Clark Liu, Chun Pereyra, Andrea Soledad Wang, Zhong Min Aggarwal, Neil D´Alessio, Franco Garibaldi, Brian T. Mock, Jason R. Singer, Benjamin D. Feng, Xin Yammani, Raghunatha R. Zhang, Tan Lee, Amy L. Philpott, Sydney Lussier, Stephanie Purcell, Lina Chou, Jeff Seeds, Michael King, Landon S. Morris, Peter E. Delbono, Osvaldo |
| author_role |
author |
| author2 |
Liu, Chun Pereyra, Andrea Soledad Wang, Zhong Min Aggarwal, Neil D´Alessio, Franco Garibaldi, Brian T. Mock, Jason R. Singer, Benjamin D. Feng, Xin Yammani, Raghunatha R. Zhang, Tan Lee, Amy L. Philpott, Sydney Lussier, Stephanie Purcell, Lina Chou, Jeff Seeds, Michael King, Landon S. Morris, Peter E. Delbono, Osvaldo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
LUNG INJURY EXERCISE SKELETAL MUSCLE WASTING |
| topic |
LUNG INJURY EXERCISE SKELETAL MUSCLE WASTING |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans. Fil: Files, D. Clark. School Of Medicine; Estados Unidos Fil: Liu, Chun. School Of Medicine; Estados Unidos Fil: Pereyra, Andrea Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Wang, Zhong Min. University Wake Forest; Estados Unidos. School Of Medicine; Estados Unidos Fil: Aggarwal, Neil. Johns Hopkins Asthma And Allergy Center; Estados Unidos Fil: D´Alessio, Franco. Johns Hopkins Asthma And Allergy Center; Estados Unidos Fil: Garibaldi, Brian T.. Johns Hopkins Asthma and Allergy Center; Estados Unidos Fil: Mock, Jason R.. Johns Hopkins Asthma and Allergy Center; Estados Unidos Fil: Singer, Benjamin D.. Johns Hopkins Asthma and Allergy Center; Estados Unidos Fil: Feng, Xin. Wake Forest School of Medicine; Estados Unidos Fil: Yammani, Raghunatha R.. Wake Forest School of Medicine; Estados Unidos Fil: Zhang, Tan. Wake Forest School of Medicine; Estados Unidos Fil: Lee, Amy L.. Wake Forest School of Medicine; Estados Unidos Fil: Philpott, Sydney. Wake Forest School of Medicine; Estados Unidos Fil: Lussier, Stephanie. Wake Forest School of Medicine; Estados Unidos Fil: Purcell, Lina. Wake Forest School of Medicine; Estados Unidos Fil: Chou, Jeff. Wake Forest School of Medicine; Estados Unidos Fil: Seeds, Michael. Wake Forest School of Medicine; Estados Unidos Fil: King, Landon S.. Johns Hopkins Asthma and Allergy Center; Estados Unidos Fil: Morris, Peter E.. Wake Forest School of Medicine; Estados Unidos Fil: Delbono, Osvaldo. School Of Medicine; Estados Unidos |
| description |
Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-03 |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/125093 Files, D. Clark; Liu, Chun; Pereyra, Andrea Soledad; Wang, Zhong Min; Aggarwal, Neil; et al.; Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting; American Association for the Advancement of Science; SCIENCE TRANSLATIONAL MEDICINE; 7; 278; 3-2015; 278-310 1946-6234 CONICET Digital CONICET |
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http://hdl.handle.net/11336/125093 |
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Files, D. Clark; Liu, Chun; Pereyra, Andrea Soledad; Wang, Zhong Min; Aggarwal, Neil; et al.; Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting; American Association for the Advancement of Science; SCIENCE TRANSLATIONAL MEDICINE; 7; 278; 3-2015; 278-310 1946-6234 CONICET Digital CONICET |
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eng |
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eng |
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American Association for the Advancement of Science |
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American Association for the Advancement of Science |
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