A minimalistic approach to develop new anti-apicomplexa polyamines analogs

Autores
Panozzo Zenere, Esteban Andrés; Porta, Exequiel Oscar Jesús; Arrizabalaga, Gustavo; Fargnoli, Lucía; Khan, Shabana I.; Tekwani, Babu L.; Labadie, Guillermo Roberto
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and evaluated against apicomplexan parasites. Different member of the series of N,N′-disubstituted aliphatic diamines shown in vitro activities at submicromolar concentrations and high levels of selectivity against Toxoplasma gondii and in chloroquine-sensitive and resistant-strains of Plasmodium falciparum. In order to demonstrate the importance of the secondary amines, ten N,N,N′,N′-tetrasubstituted aliphatic diamines derivatives were synthesized being considerably less active than their disubstituted counterpart. Theoretical studies were performed to establish the electronic factors that govern the activity of the compounds.
Fil: Panozzo Zenere, Esteban Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Porta, Exequiel Oscar Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Arrizabalaga, Gustavo. Indiana University; Estados Unidos
Fil: Fargnoli, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Khan, Shabana I.. University Of Mississippi; Estados Unidos
Fil: Tekwani, Babu L.. University Of Mississippi; Estados Unidos
Fil: Labadie, Guillermo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Química Organica; Argentina
Materia
Anti-Apicomplexa
Cheminformatics
N,N′-Disubstituted Diamines
Ntds
Polyamines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50457
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/50457
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A minimalistic approach to develop new anti-apicomplexa polyamines analogsPanozzo Zenere, Esteban AndrésPorta, Exequiel Oscar JesúsArrizabalaga, GustavoFargnoli, LucíaKhan, Shabana I.Tekwani, Babu L.Labadie, Guillermo RobertoAnti-ApicomplexaCheminformaticsN,N′-Disubstituted DiaminesNtdsPolyamineshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and evaluated against apicomplexan parasites. Different member of the series of N,N′-disubstituted aliphatic diamines shown in vitro activities at submicromolar concentrations and high levels of selectivity against Toxoplasma gondii and in chloroquine-sensitive and resistant-strains of Plasmodium falciparum. In order to demonstrate the importance of the secondary amines, ten N,N,N′,N′-tetrasubstituted aliphatic diamines derivatives were synthesized being considerably less active than their disubstituted counterpart. Theoretical studies were performed to establish the electronic factors that govern the activity of the compounds.Fil: Panozzo Zenere, Esteban Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Porta, Exequiel Oscar Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Arrizabalaga, Gustavo. Indiana University; Estados UnidosFil: Fargnoli, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Khan, Shabana I.. University Of Mississippi; Estados UnidosFil: Tekwani, Babu L.. University Of Mississippi; Estados UnidosFil: Labadie, Guillermo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Química Organica; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50457Panozzo Zenere, Esteban Andrés; Porta, Exequiel Oscar Jesús; Arrizabalaga, Gustavo; Fargnoli, Lucía; Khan, Shabana I.; et al.; A minimalistic approach to develop new anti-apicomplexa polyamines analogs; Elsevier France-editions Scientifiques Medicales Elsevier; European Journal of Medical Chemistry; 143; 1-2018; 866-8800223-5234CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2017.11.069info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523417309728info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:56:56Zoai:ri.conicet.gov.ar:11336/50457instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:56:56.324CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A minimalistic approach to develop new anti-apicomplexa polyamines analogs
title A minimalistic approach to develop new anti-apicomplexa polyamines analogs
spellingShingle A minimalistic approach to develop new anti-apicomplexa polyamines analogs
Panozzo Zenere, Esteban Andrés
Anti-Apicomplexa
Cheminformatics
N,N′-Disubstituted Diamines
Ntds
Polyamines
title_short A minimalistic approach to develop new anti-apicomplexa polyamines analogs
title_full A minimalistic approach to develop new anti-apicomplexa polyamines analogs
title_fullStr A minimalistic approach to develop new anti-apicomplexa polyamines analogs
title_full_unstemmed A minimalistic approach to develop new anti-apicomplexa polyamines analogs
title_sort A minimalistic approach to develop new anti-apicomplexa polyamines analogs
dc.creator.none.fl_str_mv Panozzo Zenere, Esteban Andrés
Porta, Exequiel Oscar Jesús
Arrizabalaga, Gustavo
Fargnoli, Lucía
Khan, Shabana I.
Tekwani, Babu L.
Labadie, Guillermo Roberto
author Panozzo Zenere, Esteban Andrés
author_facet Panozzo Zenere, Esteban Andrés
Porta, Exequiel Oscar Jesús
Arrizabalaga, Gustavo
Fargnoli, Lucía
Khan, Shabana I.
Tekwani, Babu L.
Labadie, Guillermo Roberto
author_role author
author2 Porta, Exequiel Oscar Jesús
Arrizabalaga, Gustavo
Fargnoli, Lucía
Khan, Shabana I.
Tekwani, Babu L.
Labadie, Guillermo Roberto
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Anti-Apicomplexa
Cheminformatics
N,N′-Disubstituted Diamines
Ntds
Polyamines
topic Anti-Apicomplexa
Cheminformatics
N,N′-Disubstituted Diamines
Ntds
Polyamines
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and evaluated against apicomplexan parasites. Different member of the series of N,N′-disubstituted aliphatic diamines shown in vitro activities at submicromolar concentrations and high levels of selectivity against Toxoplasma gondii and in chloroquine-sensitive and resistant-strains of Plasmodium falciparum. In order to demonstrate the importance of the secondary amines, ten N,N,N′,N′-tetrasubstituted aliphatic diamines derivatives were synthesized being considerably less active than their disubstituted counterpart. Theoretical studies were performed to establish the electronic factors that govern the activity of the compounds.
Fil: Panozzo Zenere, Esteban Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Porta, Exequiel Oscar Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Arrizabalaga, Gustavo. Indiana University; Estados Unidos
Fil: Fargnoli, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Khan, Shabana I.. University Of Mississippi; Estados Unidos
Fil: Tekwani, Babu L.. University Of Mississippi; Estados Unidos
Fil: Labadie, Guillermo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmaceuticas. Departamento de Química Organica; Argentina
description The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and evaluated against apicomplexan parasites. Different member of the series of N,N′-disubstituted aliphatic diamines shown in vitro activities at submicromolar concentrations and high levels of selectivity against Toxoplasma gondii and in chloroquine-sensitive and resistant-strains of Plasmodium falciparum. In order to demonstrate the importance of the secondary amines, ten N,N,N′,N′-tetrasubstituted aliphatic diamines derivatives were synthesized being considerably less active than their disubstituted counterpart. Theoretical studies were performed to establish the electronic factors that govern the activity of the compounds.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50457
Panozzo Zenere, Esteban Andrés; Porta, Exequiel Oscar Jesús; Arrizabalaga, Gustavo; Fargnoli, Lucía; Khan, Shabana I.; et al.; A minimalistic approach to develop new anti-apicomplexa polyamines analogs; Elsevier France-editions Scientifiques Medicales Elsevier; European Journal of Medical Chemistry; 143; 1-2018; 866-880
0223-5234
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50457
identifier_str_mv Panozzo Zenere, Esteban Andrés; Porta, Exequiel Oscar Jesús; Arrizabalaga, Gustavo; Fargnoli, Lucía; Khan, Shabana I.; et al.; A minimalistic approach to develop new anti-apicomplexa polyamines analogs; Elsevier France-editions Scientifiques Medicales Elsevier; European Journal of Medical Chemistry; 143; 1-2018; 866-880
0223-5234
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2017.11.069
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523417309728
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.891075

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